PCIDB

Flindersia laevicarpa C.T.White et Francis.

Species

KNApSAcK Entry

Organism name Flindersia laevicarpa C.T.White et Francis.
Genus Flindersia
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Flindersia
Linked NCBI taxonomy ID 43712
Linked level genus

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00013432 External link 512 Carpachromene
/ 5,4'-Dihidroxy-6'',6''-dimethylpyrano[2'',3'':7,6]flavone
/ 5-Hydroxy-8-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
No. 24 No. 15
C00000970 External link 512 Hesperidin
CHEMBL265606
CHEMBL449317
CHEMBL1314714
CHEMBL1328143
CHEMBL1535112
CHEMBL1574000
CHEMBL2140112
D006569
24 / 9 / 14 10 / 5 No. 48 No. 14
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00002198 External link 512 Skimmianine
CHEMBL21396
C035932
18 / 32 / 62 No. 368 No. 7
C00000206 External link 512 Saligel
/ Salonil
/ Salicylic acid
/ 2-Carboxyphenol
/ o-Hydroxybenzoic acid
CHEMBL424
D020156
124 / 50 / 42 15 / 12 No. 817 No. 81

Human Protein / Gene in interactions

157 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000206 C00000970 C00002198 C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000206 C00000970 C00002198 C00003672 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000206 C00000970 C00002198 C00003672 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000206 C00000970 C00002198 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000206 C00000970 C00002198 C00003672 0 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000206 C00002198 2 / 2
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000970 C00003672 1 / 1
O00255 Menin Unclassified protein C00000970 C00002198 2 / 5
P03372 Estrogen receptor NR3A1 C00000206 C00003672 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000206 C00002198 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000970 C00002198 1 / 2
O75496 Geminin Unclassified protein C00000206 C00002198 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000206 C00002198 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000206 C00002198 0 / 0
P06746 DNA polymerase beta Enzyme C00000970 C00003672 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000206 C00003672 0 / 0
P08183 Multidrug resistance protein 1 drug C00000206 C00003672 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002198 C00003672 3 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00003749 0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme C00000206 0 / 0
P29466 Caspase-1 C14 C00000206 0 / 0
P17252 Protein kinase C alpha type Alpha C00000206 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000206 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000206 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000970 0 / 0
P62158 Calmodulin Unclassified protein C00000970 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002198 11 / 10
P43166 Carbonic anhydrase 7 Lyase C00000206 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000206 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000206 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000206 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000206 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000206 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000206 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000206 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000206 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000206 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000206 0 / 0
P02768 Serum albumin Secreted protein C00000206 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000206 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000206 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000206 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000206 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000206 0 / 0
P08236 Beta-glucuronidase Enzyme C00000206 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002198 1 / 0
Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Enzyme C00000970 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000206 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000206 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000206 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000206 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000206 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000206 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000206 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000206 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000206 0 / 0
P05067 Amyloid beta A4 protein Membrane receptor C00000206 2 / 2
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000206 1 / 1
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00000206 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000206 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000206 1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000206 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000206 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000206 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000206 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000206 0 / 0
P08246 Neutrophil elastase S1A C00000206 2 / 1
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00000206 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000206 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000206 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000206 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000206 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000206 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000206 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000206 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000206 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000206 0 / 0
P15121 Aldose reductase Enzyme C00000206 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000206 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000206 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000206 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00000206 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000206 0 / 0
P08311 Cathepsin G S1A C00000206 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000206 1 / 0
P03956 Interstitial collagenase M10A C00000206 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000206 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000970 1 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00000970 1 / 2
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00000206 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000970 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00000206 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000206 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000206 0 / 0
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000206 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000206 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000206 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000206 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000206 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000206 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000206 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000206 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000206 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000206 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000206 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000206 2 / 2
Q16790 Carbonic anhydrase 9 Lyase C00000206 0 / 1
P08253 72 kDa type IV collagenase M10A C00000206 1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002198 3 / 3
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000206 0 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002198 0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00000206 0 / 0
P22894 Neutrophil collagenase M10A C00000206 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000206 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000206 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000206 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000206 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000206 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000206 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000206 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000206 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000206 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000206 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000206 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000206 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000206 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000970 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000970 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000970 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000206 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000206 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000206 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000206 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000206 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00000206 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000206 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000206 0 / 0
P08254 Stromelysin-1 M10A C00000206 1 / 0
Q9Y251 Heparanase Enzyme C00000970 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000206 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00000970 0 / 0
Q9UHC3 Acid-sensing ion channel 3 Unclassified protein C00000206 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000206 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000970 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000206 4 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00002198 7 / 37
Q02410 Amyloid beta A4 precursor protein-binding family A member 1 Unclassified protein C00000970 0 / 0
Q00975 Voltage-dependent N-type calcium channel subunit alpha-1B N-TYPE C00000970 0 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter C00000206 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000970 0 / 0

27 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000970
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000970
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00000970
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000970
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000970
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00000970
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000970
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000970
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000970
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00000970
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000206
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00000206
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000206
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000206
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000206
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00000206
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00000206
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00000206
10864 SLC22A7, NLT, OAT2 solute carrier family 22 (organic anion transporter), member 7 C00000206
114571 SLC22A9, HOAT4, OAT4, OAT7, UST3H, ust3 solute carrier family 22 (organic anion transporter), member 9 C00000206
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00000206
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000206
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000206
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000206
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000206

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (92)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#104300 Alzheimer disease; ad P05067
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#218030 Apparent mineralocorticoid excess; ame P80365
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605714 Cerebral amyloid angiopathy, app-related P05067
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#253220 Mucopolysaccharidosis, type vii; mps7 P08236
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (92)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00056 Alzheimer's disease (AD) P05067 (related)
H01185 Cerebral amyloid angiopathy (CAA) P05067 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00132 Mucopolysaccharidosis type VII (MPS7) P08236 (related)
H00421 Mucopolysaccharidosis (MPS) P08236 (related)
H00100 Neutropenic disorders P08246 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

23 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749
D058186 Acute Kidney Injury C00000970
D055371 Acute Lung Injury C00000970
D056486 Drug-Induced Liver Injury C00000970
D008171 Lung Diseases C00000970
D012128 Respiratory Distress Syndrome, Adult C00000970
D001249 Asthma C00000206
D003128 COMA C00000206
D004342 Drug Hypersensitivity C00000206
D034381 Hearing Loss C00000206
D006685 Hoarseness C00000206
D007819 Laryngeal Edema C00000206
D009668 Nose Diseases C00000206
D049188 Prenatal Injuries C00000206
D012640 Seizures C00000206
D014012 Tinnitus C00000206
D014581 Urticaria C00000206
D014860 Warts C00000206