PCIDB

Petasites hybridus

Species

KNApSAcK Entry

Organism name Petasites hybridus
Genus Petasites
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Petasites hybridus
Linked NCBI taxonomy ID 278673
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (23)

Species Activity
Petasites hybridus (L.) P. Gaertn. Et at. Analgesic
Petasites hybridus (L.) P. Gaertn. Et at. Antiinflammatory
Petasites hybridus (L.) P. Gaertn. Et at. Antileukotriene
Petasites hybridus (L.) P. Gaertn. Et at. Antilithic
Petasites hybridus (L.) P. Gaertn. Et at. Antimigraine
Petasites hybridus (L.) P. Gaertn. Et at. Antispasmodic
Petasites hybridus (L.) P. Gaertn. Et at. Antiulcer
Petasites hybridus (L.) P. Gaertn. Et at. Aperitif
Petasites hybridus (L.) P. Gaertn. Et at. Aquaretic
Petasites hybridus (L.) P. Gaertn. Et at. Carcinogenic
Petasites hybridus (L.) P. Gaertn. Et at. Cardiotonic
Petasites hybridus (L.) P. Gaertn. Et at. Cytoprotective
Petasites hybridus (L.) P. Gaertn. Et at. Diaphoretic
Petasites hybridus (L.) P. Gaertn. Et at. Diuretic
Petasites hybridus (L.) P. Gaertn. Et at. Dysuria
Petasites hybridus (L.) P. Gaertn. Et at. Emmenagogue
Petasites hybridus (L.) P. Gaertn. Et at. Hepatotoxic
Petasites hybridus (L.) P. Gaertn. Et at. Mutagenic
Petasites hybridus (L.) P. Gaertn. Et at. Sedative
Petasites hybridus (L.) P. Gaertn. Et at. Stimulant
Petasites hybridus (L.) P. Gaertn. Et at. Teratogenic
Petasites hybridus (L.) P. Gaertn. Et at. Tonic
Petasites hybridus (L.) P. Gaertn. Et at. Vermifuge

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00017409 External link 512 2alpha-(Angelyloxy)-9-oxo-10alphaH-furoeremophilane
No. 391 No. 38
C00016991 External link 512 Neopetasan
/ Alloeremophilone
/ 3-Desoxyneopetasol
/ Eremophila-9,11-dien-8-one
No. 543 No. 38
C00002092 External link 512 Integerrimine
CHEMBL362153
CHEMBL488203
8 / 1 / 5 No. 622 No. 2
C00002105 External link 512 Petasitenine
CHEMBL511627
CHEMBL1512570
CHEMBL1992587
C014738
3 / 3 / 8 No. 838 No. 2
C00002119 External link 512 Senkirkine
CHEMBL469650
CHEMBL470059
C009238
No. 838 No. 2
C00003169 External link 512 Petasin
No. 1723 No. 38
C00037617 External link 512 Petasitene
/ (-)-Petasitene
No. 2494
C00017376 External link 512 8,12-Epoxy-10alpha-Eremophila-7,11-dien-9-one
No. 2598
C00017004 External link 512 Isopetasan
/ Dehydrofukinone
/ 3-Desoxyisopetasol
No. 3973

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002092 C00002105 0 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002092 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002092 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002092 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002092 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002092 0 / 0
O00255 Menin Unclassified protein C00002105 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002105 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00002092 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002092 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196

KEGG DISEASE (11)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)