Xanthium strumarium
Species
KNApSAcK Entry
| Organism name | Xanthium strumarium |
|---|---|
| Genus | Xanthium |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Xanthium strumarium |
|---|---|
| Linked NCBI taxonomy ID | 318068 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (39)
| Species | Activity |
|---|---|
| Xanthium strumarium L. | Alexiteric |
| Xanthium strumarium L. | Analgesic |
| Xanthium strumarium L. | Anticarcinomic |
| Xanthium strumarium L. | Antiedemic |
| Xanthium strumarium L. | Antihyperglycemic |
| Xanthium strumarium L. | Antiinflammatory |
| Xanthium strumarium L. | Antimelanomic |
| Xanthium strumarium L. | Antisarcomic |
| Xanthium strumarium L. | Antiseptic |
| Xanthium strumarium L. | Antitrypanosomal |
| Xanthium strumarium L. | Antitumor |
| Xanthium strumarium L. | Antiulcer |
| Xanthium strumarium L. | Astringent |
| Xanthium strumarium L. | Bactericide |
| Xanthium strumarium L. | COX-2-Inhibitor |
| Xanthium strumarium L. | Cytotoxic |
| Xanthium strumarium L. | Demulcent |
| Xanthium strumarium L. | Diaphoretic |
| Xanthium strumarium L. | Diuretic |
| Xanthium strumarium L. | Emollient |
| Xanthium strumarium L. | Farnesylation-Inhibitor |
| Xanthium strumarium L. | Febrifuge |
| Xanthium strumarium L. | Fungicide |
| Xanthium strumarium L. | Gastroprotective |
| Xanthium strumarium L. | Gram(+)-icide |
| Xanthium strumarium L. | Hemostat |
| Xanthium strumarium L. | Hypoglycemic |
| Xanthium strumarium L. | iNOS-Inhibitor |
| Xanthium strumarium L. | MDR-Inhibitor |
| Xanthium strumarium L. | Memorigenic |
| Xanthium strumarium L. | Orexigenic |
| Xanthium strumarium L. | Peristaltic |
| Xanthium strumarium L. | Pneumonic |
| Xanthium strumarium L. | Refrigerant |
| Xanthium strumarium L. | Sedative |
| Xanthium strumarium L. | Sialagogue |
| Xanthium strumarium L. | Sudorific |
| Xanthium strumarium L. | TNF-alpha-Inhibitor |
| Xanthium strumarium L. | Tonic |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004684
|
Axillarin
/ Quercetagetin 3,6-dimethyl ether / 3,6-Dimethoxy-5,7,3',4'-tetrahydroxyflavone / 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL487810
|
C056669
|
1 / 1 / 1 | No. 3 | No. 15 |
|
|
|
C00004593
|
6-Methoxykaempferol
/ 3,5,7,4'-Tetrahydroxy-6-methoxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one |
CHEMBL462898
|
No. 3 | No. 15 |
|
|||
|
C00004034
|
5,7,3',4'-Tetrahydroxy-8-prenylflavone
|
CHEMBL1783943
|
1 / 4 / 1 | No. 15 | No. 15 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00003647
|
Campesterol
/ 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol |
CHEMBL520535
CHEMBL485421 CHEMBL1836653 |
C021273
|
No. 53 | No. 11 |
|
||
|
C00044046
|
1,5-Di-O-caffeoylquinic acid
|
CHEMBL431948
CHEMBL487258 CHEMBL478574 CHEMBL1213299 CHEMBL2105478 CHEMBL2356300 |
6 / 5 / 7 | No. 518 | No. 6 |
|
||
|
C00000206
|
Saligel
/ Salonil / Salicylic acid / 2-Carboxyphenol / o-Hydroxybenzoic acid |
CHEMBL424
|
D020156
|
124 / 50 / 42 | 15 / 12 | No. 817 | No. 81 |
|
|
C00000615
|
Caffeic acid
|
CHEMBL145
CHEMBL1320034 |
68 / 64 / 63 | No. 904 | No. 6 |
|
||
|
C00011540
|
Nigellic acid
|
CHEMBL396834
|
No. 1435 | No. 38 |
|
|||
|
C00020337
|
Isoxanthanol
/ 4-Acetylivalbin |
No. 1750 | No. 38 |
|
||||
|
C00020336
|
Xanthanol
/ Xanthumanol / 2-Acetylivalbin |
No. 1750 | No. 38 |
|
||||
|
C00003395
|
Xanthumin
|
CHEMBL1982362
|
No. 1750 | No. 38 |
|
|||
|
C00044045
|
1,3,5-Tri-O-caffeoylquinic acid
|
CHEMBL499997
|
No. 2423 |
|
||||
|
C00029117
|
Thiazinedione
|
No. 8881 |
|
Human Protein / Gene in interactions
175 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000206 C00000615 C00003672 | 1 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000206 C00000615 C00003672 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000206 C00000615 C00003672 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000206 C00000615 C00003672 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000615 C00003672 C00023774 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000206 C00000615 C00003672 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000206 C00000615 C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000206 C00000615 C00003672 | 0 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000206 C00000615 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000206 C00000615 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000206 C00000615 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000206 C00000615 | 2 / 2 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000206 C00044046 | 0 / 1 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000206 C00000615 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000206 C00000615 | 2 / 2 |
| P08253 | 72 kDa type IV collagenase | M10A | C00000206 C00000615 | 1 / 3 |
| P24298 | Alanine aminotransferase 1 | Enzyme | C00000615 C00044046 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000206 C00000615 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000206 C00000615 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000206 C00000615 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000206 C00000615 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000206 C00000615 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000206 C00000615 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00000615 C00003672 | 4 / 2 |
| P03956 | Interstitial collagenase | M10A | C00000206 C00000615 | 0 / 1 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000206 C00000615 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00000206 C00000615 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000206 C00000615 | 2 / 2 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000206 C00000615 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000206 C00000615 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000615 C00003672 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000615 C00004684 | 1 / 1 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000206 C00000615 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000206 C00000615 | 1 / 2 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000206 C00000615 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000206 C00000615 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000206 C00000615 | 1 / 8 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000615 C00003672 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00000206 C00003672 | 1 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000206 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000206 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00000206 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00000615 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000206 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000206 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000206 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000206 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000206 | 0 / 0 |
| P08236 | Beta-glucuronidase | Enzyme | C00000206 | 1 / 2 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00000615 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000206 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000206 | 2 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000206 | 1 / 1 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000206 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000206 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000206 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000206 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000206 | 0 / 1 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000206 | 0 / 0 |
| P05067 | Amyloid beta A4 protein | Membrane receptor | C00000206 | 2 / 2 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000206 | 1 / 1 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00000206 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000206 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000206 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000615 | 3 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000615 | 11 / 10 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000206 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000615 | 0 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000615 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00000615 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000206 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000206 | 0 / 0 |
| Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | C00000206 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000206 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000206 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000206 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000206 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000206 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000206 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000206 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000206 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000206 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000206 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000206 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000206 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000206 | 1 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000206 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000206 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000206 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000206 | 1 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00044046 | 1 / 2 |
| P29466 | Caspase-1 | C14 | C00000206 | 0 / 0 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000206 | 0 / 0 |
| Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | C00000206 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000206 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000206 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000206 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00000615 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000206 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000206 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000206 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000206 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000206 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00044046 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000206 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000206 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000206 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00000615 | 1 / 1 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00000615 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000206 | 1 / 0 |
| P22894 | Neutrophil collagenase | M10A | C00000206 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000206 | 2 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000615 | 1 / 1 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000206 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000206 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000615 | 3 / 3 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00044046 | 1 / 1 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000615 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000615 | 3 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000615 | 5 / 2 |
| P06133 | UDP-glucuronosyltransferase 2B4 | Enzyme | C00000206 | 0 / 0 |
| P36537 | UDP-glucuronosyltransferase 2B10 | Enzyme | C00000206 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000206 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000206 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000206 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000206 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000206 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000206 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000206 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000206 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000206 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000206 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000206 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000206 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000615 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00004034 | 4 / 1 |
| P08246 | Neutrophil elastase | S1A | C00000206 | 2 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000206 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000206 | 0 / 0 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000615 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000615 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000615 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000615 | 4 / 3 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000206 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000206 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000206 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000206 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000206 | 1 / 1 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00000615 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000206 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00000206 | 1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000206 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00000615 | 1 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000615 | 0 / 0 |
| Q9UHC3 | Acid-sensing ion channel 3 | Unclassified protein | C00000206 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000615 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000206 | 4 / 1 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00044046 | 3 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000615 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000615 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00000615 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000615 | 1 / 2 |
| Q9NSA0 | Solute carrier family 22 member 11 | Transporter | C00000206 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00000615 | 0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00000615 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000615 | 0 / 0 |
16 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00000206
|
| 1646 | AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 | aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) |
C00000206
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00000206
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00000206
|
| 23764 | MAFF, U-MAF, hMafF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
C00000206
|
| 4489 | MT1A, MT1, MT1S, MTC | metallothionein 1A |
C00000206
|
| 55867 | SLC22A11, OAT4, hOAT4 | solute carrier family 22 (organic anion/urate transporter), member 11 |
C00000206
|
| 9356 | SLC22A6, HOAT1, OAT1, PAHT, ROAT1 | solute carrier family 22 (organic anion transporter), member 6 |
C00000206
|
| 10864 | SLC22A7, NLT, OAT2 | solute carrier family 22 (organic anion transporter), member 7 |
C00000206
|
| 114571 | SLC22A9, HOAT4, OAT4, OAT7, UST3H, ust3 | solute carrier family 22 (organic anion transporter), member 9 |
C00000206
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00000206
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000206
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00000206
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000206
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000206
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (116)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #104300 | Alzheimer disease; ad |
P05067
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #114480 | Breast cancer |
P31749
|
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605714 | Cerebral amyloid angiopathy, app-related |
P05067
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #253220 | Mucopolysaccharidosis, type vii; mps7 |
P08236
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #176920 | Proteus syndrome |
P31749
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (87)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00056 | Alzheimer's disease (AD) |
P05067
(related)
|
| H01185 | Cerebral amyloid angiopathy (CAA) |
P05067
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00132 | Mucopolysaccharidosis type VII (MPS7) |
P08236
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
P08236
(related)
Q12794 (related) |
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001249 | Asthma |
C00000206
|
| D003128 | COMA |
C00000206
|
| D004342 | Drug Hypersensitivity |
C00000206
|
| D034381 | Hearing Loss |
C00000206
|
| D006685 | Hoarseness |
C00000206
|
| D007819 | Laryngeal Edema |
C00000206
|
| D009668 | Nose Diseases |
C00000206
|
| D049188 | Prenatal Injuries |
C00000206
|
| D012640 | Seizures |
C00000206
|
| D014012 | Tinnitus |
C00000206
|
| D014581 | Urticaria |
C00000206
|
| D014860 | Warts |
C00000206
|