Species

KNApSAcK Entry

Organism name Oricia suaveolens
Genus Oricia
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Oricia
Linked NCBI taxonomy ID 722394
Linked level genus

Family

Family in NCBI taxonomy Notodontidae
ID 37571

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Metazoa
ID 33208

Plant class

Plant class
ID

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00003719 External link 512 Limonin
CHEMBL1523286
CHEMBL1886762
CHEMBL1897224
CHEMBL2004366
C001546
2 / 0 / 1 1 / 1 No. 204 No. 51
C00002161 External link 512 Flindersiamine
/ 8-Methoxy-6,7-methylenedioxydictamnine
CHEMBL503519
C012321
No. 368 No. 7
C00002198 External link 512 Skimmianine
CHEMBL21396
C035932
18 / 32 / 62 No. 368 No. 7
C00002183 External link 512 Maculine
CHEMBL503675
No. 368 No. 7
C00002177 External link 512 Kokusaginine
CHEMBL278779
9 / 7 / 3 No. 368 No. 7
C00026434 External link 512 Halfordinine
/ 6,7,8-Trimethoxydictamnine
No. 368 No. 7
C00026391 External link 512 5-Methoxymaculine
CHEMBL461610
No. 368 No. 7
C00026463 External link 512 Nkolbisine
/ Montrifoline
/ (-)-Nkolbisine
/ (-)-Montrifoline
No. 600 No. 7
C00040137 External link 512 Quinosuaveoline A
/ (-)-Quinosuaveoline A
No. 600 No. 7
C00040138 External link 512 Quinosuaveoline B
/ (+)-Quinosuaveoline B
CHEMBL574554
No. 600 No. 7
C00039905 External link 512 Orisuaveoline A
CHEMBL575438
No. 1009 No. 7
C00026491 External link 512 Tecleaverdoornine
CHEMBL572482
No. 1996
C00039906 External link 512 Orisuaveoline B
CHEMBL574332
No. 6058

Human Protein / Gene in interactions

55 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q92830 Histone acetyltransferase KAT2A Enzyme C00002198 C00019064 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002177 C00002198 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002177 C00019064 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002198 C00003719 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002198 C00019064 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002177 C00019064 0 / 0
O75496 Geminin Unclassified protein C00002198 C00019064 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019064 0 / 0
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00019064 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00019064 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002198 11 / 10
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P37840 Alpha-synuclein Unclassified protein C00002177 4 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00002198 3 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00019064 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002198 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002198 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019064 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002198 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002198 1 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002177 2 / 0
P06746 DNA polymerase beta Enzyme C00019064 0 / 0
P15121 Aldose reductase Enzyme C00019064 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002177 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019064 0 / 3
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019064 2 / 2
Q96RI1 Bile acid receptor NR1H4 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002198 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002198 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002198 2 / 2
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00019064 0 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002198 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002177 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00019064 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002198 7 / 37
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002177 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00019064 0 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00019064 0 / 0
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00019064 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019064 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003719 0 / 0
O00255 Menin Unclassified protein C00002198 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002198 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00019064 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00019064 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002177 1 / 1

22 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00003719 C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019064
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00019064
847 CAT catalase (EC:1.11.1.6) C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (47)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#163950 Noonan syndrome 1; ns1 Q06124
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (72)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35228 (related)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

22 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001862 Bone Resorption C00003719
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749
D002252 Carbon Tetrachloride Poisoning C00019064
D056486 Drug-Induced Liver Injury C00019064
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D006949 Hyperlipidemias C00019064
D007249 Inflammation C00019064
D007674 Kidney Diseases C00019064
D008103 Liver Cirrhosis C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D017202 Myocardial Ischemia C00019064
D009369 Neoplasms C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064