KEGG   PATHWAY: pon00980
Entry
pon00980                    Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Pongo abelii (Sumatran orangutan)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pon00980  Metabolism of xenobiotics by cytochrome P450
pon00980

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100457153  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100450749  cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
100436782  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
100172192  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100174562  GSTM2; glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
100437206  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100437569  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100439198  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100445078  glutathione S-transferase A2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100445448  GSTA1; glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100446578  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100447725  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100448103  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
100450689  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100450954  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100452892  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100453263  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
100453622  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100454483  glutathione S-transferase Mu 1 isoform X5 [KO:K00799] [EC:2.5.1.18]
100461022  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100445831  LOW QUALITY PROTEIN: glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
100439941  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
100450224  LOW QUALITY PROTEIN: glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
100451109  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100449856  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100442886  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
100450378  LOW QUALITY PROTEIN: glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
100432722  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112133809  glutathione S-transferase A5-like [KO:K00799] [EC:2.5.1.18]
100449495  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100174544  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
100171904  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
100442014  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100173792  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
100437687  epoxide hydrolase 1-like isoform X1 [KO:K01253] [EC:3.3.2.9]
100458142  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
100457779  cytochrome P450 2B6-like [KO:K17709] [EC:1.14.14.-]
100431471  SULT2A1; bile salt sulfotransferase [KO:K11822] [EC:2.8.2.14]
100172368  CYP1A2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
100457048  cytochrome P450 2A6 isoform X1 [KO:K17683] [EC:1.14.14.-]
100173813  CYP2E1; cytochrome P450 2E1 precursor [KO:K07415] [EC:1.14.14.-]
100456680  cytochrome P450 2F1 [KO:K07416] [EC:1.14.14.1]
100459240  cytochrome P450 2S1 isoform X1 [KO:K07420] [EC:1.14.14.1]
100189776  aldo-keto reductase family 1 member C1 homolog isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
100171658  AKR1C1; aldo-keto reductase family 1 member C1 homolog [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
100174691  DHDH; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
100458875  cytochrome P450 2A13 isoform X1 [KO:K17685] [EC:1.14.14.1]
100452833  LOW QUALITY PROTEIN: cytochrome P450 2D6-like [KO:K17712] [EC:1.14.14.1]
100453198  cytochrome P450 2D6-like [KO:K17712] [EC:1.14.14.1]
100458527  cytochrome P450 2D6 isoform X1 [KO:K17712] [EC:1.14.14.1]
100453076  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [KO:K15680] [EC:1.1.1.146]
100460111  HSD11B1L; hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform X1 [KO:K15680] [EC:1.1.1.146]
100172097  CBR1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100452311  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
100445423  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
100171521  UGT2B7; UDP-glucuronosyltransferase 2B7 precursor [KO:K00699] [EC:2.4.1.17]
100172533  UGT1A3; UDP-glucuronosyltransferase 1-3 precursor [KO:K00699] [EC:2.4.1.17]
100174202  UGT2A3; UDP-glucuronosyltransferase 2A3 precursor [KO:K00699] [EC:2.4.1.17]
100441531  UDP-glucuronosyltransferase 2B10 isoform X1 [KO:K00699] [EC:2.4.1.17]
100446928  UGT2B4; UDP-glucuronosyltransferase 2B4 isoform X4 [KO:K00699] [EC:2.4.1.17]
100447782  UGT2A1; UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
100460599  UGT2B17; UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
100444573  UDP-glucuronosyltransferase 2B30 isoform X1 [KO:K00699] [EC:2.4.1.17]
100446313  UDP-glucuronosyltransferase 2B11 isoform X2 [KO:K00699] [EC:2.4.1.17]
100461334  UDP-glucuronosyltransferase 2B15 isoform X1 [KO:K00699] [EC:2.4.1.17]
100447519  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-9 [KO:K00699] [EC:2.4.1.17]
100431382  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7 [KO:K00699] [EC:2.4.1.17]
100434899  cytochrome P450 3A5 isoform X1 [KO:K17690] [EC:1.14.14.1]
100456442  AKR7A3; aflatoxin B1 aldehyde reductase member 3 [KO:K15303]
100456086  aflatoxin B1 aldehyde reductase member 4 [KO:K15303]
100939526  AKR7A2; aflatoxin B1 aldehyde reductase member 2 isoform X1 [KO:K15303]
100446485  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
100450634  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
100453112  ALDH3B2; aldehyde dehydrogenase family 3 member B2 isoform X1 [KO:K00129] [EC:1.2.1.5]
100172370  ADH1A; alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
100451932  alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
100454155  ADH7; alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [KO:K13951] [EC:1.1.1.1]
100452306  ADH1B; alcohol dehydrogenase 1B [KO:K13951] [EC:1.1.1.1]
100451184  ADH4; alcohol dehydrogenase 4 isoform X2 [KO:K13980] [EC:1.1.1.1]
100450815  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100173203  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
PMID:12487150
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
PMID:10725110
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
PMID:10570027
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
PMID:10490505
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v
Reference
PMID:15319346
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
PMID:15987776
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160
Reference
PMID:15298956
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
ko00980   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (81)   
   KEGG GENES (81)   
All databases (82)   

Download RDF
DBGET integrated database retrieval system