Entry |
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Name |
Rap1 signaling pathway - Rattus norvegicus (rat)
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Description |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
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Class |
Environmental Information Processing; Signal transduction
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Pathway map |

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Other DBs |
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Organism |
Rattus norvegicus (rat) [GN: rno]
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Gene |
362799 | Rapgef5; rap guanine nucleotide exchange factor 5 [KO:K08019] |
366608 | Dock4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697] |
24408 | Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208] |
24409 | Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209] |
24410 | Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210] |
25439 | F2r; proteinase-activated receptor 1 precursor [KO:K03914] |
66025 | Lpar3; lysophosphatidic acid receptor 3 [KO:K04294] |
24896 | Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632] |
59326 | Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014] |
252857 | Rapgef4; rap guanine nucleotide exchange factor 4 [KO:K04351] |
81666 | Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634] |
24654 | Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11] |
29322 | Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11] |
85240 | Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11] |
25031 | Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11] |
25313 | Egf; pro-epidermal growth factor precursor [KO:K04357] |
170633 | Fgf3; fibroblast growth factor 3 precursor [KO:K04358] |
116499 | Fgf4; fibroblast growth factor 4 precursor [KO:K04358] |
60662 | Fgf5; fibroblast growth factor 5 precursor [KO:K04358] |
29348 | Fgf7; fibroblast growth factor 7 precursor [KO:K04358] |
29349 | Fgf8; fibroblast growth factor 8 precursor [KO:K04358] |
25443 | Fgf10; fibroblast growth factor 10 precursor [KO:K04358] |
29368 | Fgf17; fibroblast growth factor 17 precursor [KO:K04358] |
29369 | Fgf18; fibroblast growth factor 18 precursor [KO:K04358] |
170579 | Fgf22; fibroblast growth factor 22 precursor [KO:K04358] |
170582 | Fgf19; fibroblast growth factor 19 precursor [KO:K22603] |
170580 | Fgf21; fibroblast growth factor 21 precursor [KO:K22429] |
170583 | Fgf23; fibroblast growth factor 23 precursor [KO:K22428] |
24482 | Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459] |
25266 | Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359] |
24628 | Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386] |
79429 | Pdgfc; platelet-derived growth factor C precursor [KO:K05450] |
66018 | Pdgfd; platelet-derived growth factor D precursor [KO:K05450] |
78965 | Csf1; macrophage colony-stimulating factor 1 precursor [KO:K05453] |
60427 | Kitlg; kit ligand isoform 1 precursor [KO:K05461] |
83785 | Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448] |
89811 | Vegfb; vascular endothelial growth factor B precursor [KO:K16858] |
94203 | Pgf; placenta growth factor precursor [KO:K16859] |
114111 | Vegfc; vascular endothelial growth factor C precursor [KO:K05449] |
360457 | Vegfd; vascular endothelial growth factor D precursor [KO:K05449] |
24446 | Hgf; hepatocyte growth factor preproprotein [KO:K05460] |
24596 | Ngfr; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583] |
25267 | Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1] |
54251 | Flt1; vascular endothelial growth factor receptor 1 isoform 2 precursor [KO:K05096] [EC:2.7.10.1] |
63881 | Rapgef1; rap guanine nucleotide exchange factor 1 isoform X19 [KO:K06277] |
25414 | Bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726] |
500261 | Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631] |
113970 | Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629] |
245903 | Magi3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 [KO:K06112] |
310533 | Rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018] |
303141 | Rapgef6; rap guanine nucleotide exchange factor 6 [KO:K08020] |
81511 | Lat; linker for activation of T-cells family member 1 [KO:K07362] |
286975 | Skap1; src kinase-associated phosphoprotein 1 [KO:K17699] |
25738 | Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11] |
25686 | Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630] |
25643 | Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630] |
81664 | Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630] |
50664 | Gnao1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534] |
313644 | Rap1gap; rap1 GTPase-activating protein 1 [KO:K17700] |
246212 | Sipa1l1; signal-induced proliferation-associated 1-like protein 1 isoform 1 [KO:K17701] |
361710 | Sipa1; signal-induced proliferation-associated protein 1 [KO:K08013] |
361442 | Sipa1l2; signal-induced proliferation-associated 1-like protein 2 [KO:K17702] |
25261 | Id1; DNA-binding protein inhibitor ID-1 [KO:K04680] |
29622 | Ralgds; ral guanine nucleotide dissociation stimulator [KO:K08732] |
363875 | Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392] |
366957 | Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860] |
307171 | Apbb1ip; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704] |
361517 | Vasp; vasodilator-stimulated phosphoprotein [KO:K06274] |
361314 | Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4 [KO:K12490] |
297173 | RSA-14-44; ras homolog gene family, member A [KO:K04513] |
316639 | Farp2; FERM, RhoGEF and pleckstrin domain-containing protein 2 [KO:K06082] |
64465 | Cdc42; cell division control protein 42 homolog [KO:K04393] |
295378 | Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730] |
296603 | Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730] |
304109 | Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731] |
81918 | Pard3; partitioning defective 3 homolog [KO:K04237] |
307237 | Pard6g; partitioning defective 6 homolog gamma [KO:K06093] |
307799 | Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093] |
362279 | Pard6b; partitioning defective 6 homolog beta [KO:K06093] |
362317 | Krit1; krev interaction trapped protein 1 [KO:K17705] |
114705 | Rgs14; regulator of G-protein signaling 14 [KO:K17706] |
54355 | Rassf5; ras association domain-containing protein 5 [KO:K08015] |
58960 | Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2] |
85243 | Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153] |
170911 | Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153] |
366508 | Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153] |
25513 | Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649] |
60664 | Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649] |
29741 | Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649] |
114633 | Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11] |
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Compound |
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Reference |
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Authors |
Kooistra MR, Dube N, Bos JL |
Title |
Rap1: a key regulator in cell-cell junction formation. |
Journal |
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Reference |
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Authors |
Bos JL, de Rooij J, Reedquist KA |
Title |
Rap1 signalling: adhering to new models. |
Journal |
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Reference |
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Authors |
Minato N, Kometani K, Hattori M |
Title |
Regulation of immune responses and hematopoiesis by the Rap1 signal. |
Journal |
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Reference |
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Authors |
Bos JL |
Title |
Linking Rap to cell adhesion. |
Journal |
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Reference |
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Authors |
Caron E |
Title |
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. |
Journal |
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Reference |
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Authors |
Zwartkruis FJ, Bos JL |
Title |
Ras and Rap1: two highly related small GTPases with distinct function. |
Journal |
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Reference |
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Authors |
Hattori M, Minato N |
Title |
Rap1 GTPase: functions, regulation, and malignancy. |
Journal |
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Reference |
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Authors |
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL |
Title |
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors. |
Journal |
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Reference |
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Authors |
Boettner B, Van Aelst L |
Title |
Control of cell adhesion dynamics by Rap1 signaling. |
Journal |
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Reference |
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Authors |
Xia Z, Storm DR. |
Title |
The role of calmodulin as a signal integrator for synaptic plasticity. |
Journal |
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Reference |
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Authors |
Mor A, Dustin ML, Philips MR |
Title |
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. |
Journal |
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Reference |
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Authors |
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y |
Title |
T-cell receptor signaling to integrins. |
Journal |
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Reference |
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Authors |
Stork PJ |
Title |
Does Rap1 deserve a bad Rap? |
Journal |
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Reference |
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Authors |
Banihashemi B, Albert PR |
Title |
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements. |
Journal |
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Reference |
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Authors |
Banno A, Ginsberg MH |
Title |
Integrin activation. |
Journal |
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Reference |
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Authors |
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR |
Title |
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. |
Journal |
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Reference |
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Authors |
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F |
Title |
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications. |
Journal |
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Related pathway |
rno04660 | T cell receptor signaling pathway |
rno04810 | Regulation of actin cytoskeleton |
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KO pathway |
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