KEGG   PATHWAY: bta04310
Entry
bta04310                    Pathway                                
Name
Wnt signaling pathway - Bos taurus (cow)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
bta04310  Wnt signaling pathway
bta04310

Other DBs
GO: 0016055
Organism
Bos taurus (cow) [GN:bta]
Gene
100138998  [KO:K08957] [EC:2.7.11.1]
100140342  [KO:K04506] [EC:2.3.2.27]
100336539  [KO:K04506] [EC:2.3.2.27]
100336662  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399]
100337066  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
101905588  [KO:K00181] [EC:2.3.1.250]
101905713  CXXC4; LOW QUALITY PROTEIN: CXXC-type zinc finger protein 4 [KO:K03344]
101906182  [KO:K04506] [EC:2.3.2.27]
101907097  [KO:K04506] [EC:2.3.2.27]
112445131  [KO:K04506] [EC:2.3.2.27]
112446327  [KO:K03347]
112446776  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
132343618  PRICKLE4; prickle-like protein 4 isoform X1 [KO:K04511]
280831  JUN; transcription factor Jun [KO:K04448]
281170  FRZB; secreted frizzled-related protein 3 precursor [KO:K25481]
281386  SERPINF1; pigment epithelium-derived factor precursor [KO:K19614]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
281730  CTBP2; C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
282068  SFRP1; secreted frizzled-related protein 1 precursor [KO:K02166]
282069  SFRP5; secreted frizzled-related protein 5 precursor [KO:K02222]
282162  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282419  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
282420  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
282684  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
282705  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
282859  CBY1; protein chibby homolog 1 [KO:K23402]
282880  SOST; sclerostin precursor [KO:K16834]
286794  MMP7; matrilysin precursor [KO:K01397] [EC:3.4.24.23]
286852  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
338049  RHOA; transforming protein RhoA [KO:K04513]
353106  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
407228  CUL1; cullin-1 [KO:K03347]
445416  FZD4; frizzled-4 precursor [KO:K02354]
445417  FZD1; frizzled-1 [KO:K02432]
445418  FZD6; frizzled-6 [KO:K02376]
445419  FZD3; frizzled-3 precursor [KO:K02329]
445420  WNT2B; protein Wnt-2b [KO:K00182]
493729  WNT2; protein Wnt-2 precursor [KO:K00182]
504357  AXIN1; axin-1 [KO:K02157]
504411  LZTS2; leucine zipper putative tumor suppressor 2 [KO:K26471]
504445  DKK1; dickkopf-related protein 1 [KO:K02165]
505075  WNT6; protein Wnt-6 precursor [KO:K00445]
505120  TLE7; transducin-like enhancer protein 7 isoform X2 [KO:K04497]
505423  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309]
505453  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
505664  FRAT1; proto-oncogene FRAT1 [KO:K03069]
507111  CHD8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:5.6.2.-]
507114  CCAR2; cell cycle and apoptosis regulator protein 2 [KO:K25816]
507204  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
508008  WNT5B; protein Wnt-5b precursor [KO:K00444]
508019  CER1; cerberus [KO:K01645]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
508893  TLE4; transducin-like enhancer protein 4 [KO:K04497]
509040  APCDD1; protein APCDD1 isoform X2 [KO:K25812]
509338  DKK4; dickkopf-related protein 4 [KO:K02165]
509780  PRICKLE3; prickle planar cell polarity protein 3 [KO:K04511]
510821  SFRP2; secreted frizzled-related protein 2 precursor [KO:K02176]
511077  MYC; myc proto-oncogene protein [KO:K04377]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
511308  WNT9A; protein Wnt-9a [KO:K01064]
511475  RUVBL1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
511478  TLE6; transducin-like enhancer protein 6 isoform X1 [KO:K04497]
511619  AXIN2; axin-2 [KO:K04385]
511675  RSPO1; R-spondin-1 precursor [KO:K19471]
513056  VANGL1; vang-like protein 1 [KO:K04510]
513131  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
513742  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
514326  TLE3; transducin-like enhancer protein 3 [KO:K04497]
515039  CCDC88C; protein Daple [KO:K25811]
515125  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
515303  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
515323  FZD10; frizzled-10 precursor [KO:K02842]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
515972  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
517783  RSPO4; R-spondin-4 [KO:K23099]
518004  SFRP4; secreted frizzled-related protein 4 precursor [KO:K02185]
518880  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
520189  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 precursor [KO:K04308]
520544  VANGL2; vang-like protein 2 [KO:K04510]
521364  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
522467  WNT3A; protein Wnt-3a [KO:K00312]
523325  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
523661  CTNND2; catenin delta-2 isoform X2 [KO:K23491]
524255  FZD7; frizzled-7 precursor [KO:K02432]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
525416  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
525682  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
526572  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
529146  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
529698  INVS; inversin [KO:K19626]
530005  WNT5A; protein Wnt-5a [KO:K00444]
530147  BAMBI; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162]
530401  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
530719  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
531389  FOSL1; fos-related antigen 1 [KO:K04502]
532713  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
533233  APC; adenomatous polyposis coli protein [KO:K02085]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
533595  TLE2; transducin-like enhancer protein 2 isoform X3 [KO:K04497]
533672  WIF1; wnt inhibitory factor 1 precursor [KO:K01691]
533782  WNT7A; protein Wnt-7a [KO:K00572]
534010  SOX17; transcription factor SOX-17 [KO:K04495]
534072  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534450  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
534650  RSPO3; R-spondin-3 precursor [KO:K23098]
534655  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
535399  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
535441  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
536121  RSPO2; R-spondin-2 precursor [KO:K23097]
536328  LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
537192  PRICKLE2; prickle-like protein 2 isoform X2 [KO:K04511]
537330  WNT10A; protein Wnt-10a precursor [KO:K01357]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
538507  FZD2; frizzled-2 [KO:K02235]
538536  FZD5; frizzled-5 [KO:K02375]
538627  WNT16; protein Wnt-16 precursor [KO:K01558]
538720  WNT8B; protein Wnt-8b [KO:K00714]
539003  CTNNB1; catenin beta-1 [KO:K02105]
539144  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
539163  CCN4; CCN family member 4 isoform X1 [KO:K22471]
539203  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
539235  CSNK2B; casein kinase II subunit beta [KO:K03115]
539337  WNT10B; protein Wnt-10b [KO:K01357]
539639  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
540179  GPC4; glypican-4 precursor [KO:K08110]
540199  WNT8A; protein Wnt-8a [KO:K00714]
540248  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
540373  PORCN; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
540481  TCF7L2; transcription factor 7-like 2 [KO:K04491]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
540642  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
540662  WNT1; proto-oncogene Wnt-1 precursor [KO:K03209]
540753  WNT3; proto-oncogene Wnt-3 precursor [KO:K00312]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
541161  DKK2; dickkopf-related protein 2 precursor [KO:K02165]
541243  WNT9B; protein Wnt-9b [KO:K01064]
613288  WNT11; protein Wnt-11 [KO:K01384]
613515  [KO:K08957] [EC:2.7.11.1]
613629  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
614312  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
614346  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
614630  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
615414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
615427  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
616704  MCC; colorectal mutant cancer protein [KO:K26734]
616913  FZD8; frizzled-8 [KO:K02375]
617376  APCDD1L; protein APCDD1-like [KO:K25812]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
618428  CACYBP; calcyclin-binding protein [KO:K04507]
618586  NKD1; protein naked cuticle homolog 1 [KO:K03213]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
768234  CSNK1E; casein kinase I [KO:K08960] [EC:2.7.11.1]
780968  [KO:K03868] [EC:2.3.2.32]
781353  RYK; tyrosine-protein kinase RYK isoform X2 [KO:K05128] [EC:2.7.10.1]
782690  TCF7; transcription factor 7 [KO:K02620]
783665  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X2 [KO:K04512]
783965  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122] [EC:2.7.10.1]
784035  RNF43; E3 ubiquitin-protein ligase RNF43 precursor [KO:K15694] [EC:2.3.2.27]
785152  PRICKLE1; prickle-like protein 1 [KO:K04511]
785423  CSNK1B; casein kinase I isoform beta [KO:K08957] [EC:2.7.11.1]
785924  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 precursor [KO:K05123] [EC:2.7.10.1]
788119  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
789390  NKD2; protein naked cuticle homolog 2 [KO:K03213]
789600  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
bta04010  MAPK signaling pathway
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04120  Ubiquitin mediated proteolysis
bta04350  TGF-beta signaling pathway
bta04510  Focal adhesion
bta04520  Adherens junction
bta05010  Alzheimer disease
KO pathway
ko04310   

  All links  
No link information was found.
DBGET integrated database retrieval system