KEGG   PATHWAY: bta04310Help
Entry
bta04310                    Pathway                                

Name
Wnt signaling pathway - Bos taurus (cow)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
bta04310  Wnt signaling pathway
bta04310

Ortholog table
Module
bta_M00380  SCF-BTRC complex [PATH:bta04310]
bta_M00677  Wnt signaling [PATH:bta04310]
Other DBs
GO: 0016055
Organism
Bos taurus (cow) [GN:bta]
Gene
540373  PORCN; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
540662  WNT1; proto-oncogene Wnt-1 precursor [KO:K03209]
445420  WNT2B; protein Wnt-2b [KO:K00182]
493729  WNT2; protein Wnt-2 precursor [KO:K00182]
540753  WNT3; proto-oncogene Wnt-3 precursor [KO:K00312]
522467  WNT3A; protein Wnt-3a [KO:K00312]
789600  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
530005  WNT5A; protein Wnt-5a [KO:K00444]
508008  WNT5B; protein Wnt-5b precursor [KO:K00444]
505075  WNT6; protein Wnt-6 precursor [KO:K00445]
533782  WNT7A; protein Wnt-7a [KO:K00572]
100337066  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
540199  WNT8A; protein Wnt-8a [KO:K00714]
538720  WNT8B; protein Wnt-8b [KO:K00714]
511308  WNT9A; protein Wnt-9a [KO:K01064]
541243  WNT9B; protein Wnt-9b [KO:K01064]
539337  WNT10B; protein Wnt-10b [KO:K01357]
537330  WNT10A; protein Wnt-10a precursor [KO:K01357]
613288  WNT11; protein Wnt-11 [KO:K01384]
538627  WNT16; protein Wnt-16 precursor [KO:K01558]
508019  CER1; cerberus [KO:K01645]
525682  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
533672  WIF1; wnt inhibitory factor 1 precursor [KO:K01691]
281386  SERPINF1; pigment epithelium-derived factor precursor [KO:K19614]
282880  SOST; sclerostin precursor [KO:K16834]
504445  DKK1; dickkopf-related protein 1 [KO:K02165]
509338  DKK4; dickkopf-related protein 4 [KO:K02165]
541161  DKK2; dickkopf-related protein 2 precursor [KO:K02165]
282068  SFRP1; secreted frizzled-related protein 1 precursor [KO:K02166]
510821  SFRP2; secreted frizzled-related protein 2 precursor [KO:K02176]
518004  SFRP4; secreted frizzled-related protein 4 precursor [KO:K02185]
282069  SFRP5; secreted frizzled-related protein 5 precursor [KO:K02222]
511675  RSPO1; R-spondin-1 precursor [KO:K19471]
536121  RSPO2; R-spondin-2 precursor [KO:K23097]
534650  RSPO3; R-spondin-3 precursor [KO:K23098]
517783  RSPO4; R-spondin-4 [KO:K23099]
505423  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 precursor [KO:K04309]
520189  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 precursor [KO:K04308]
100336662  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1 [KO:K08399]
784035  RNF43; E3 ubiquitin-protein ligase RNF43 precursor [KO:K15694] [EC:2.3.2.27]
535441  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
445417  FZD1; frizzled-1 [KO:K02432]
524255  FZD7; frizzled-7 precursor [KO:K02432]
538507  FZD2; frizzled-2 [KO:K02235]
445419  FZD3; frizzled-3 precursor [KO:K02329]
445416  FZD4; frizzled-4 precursor [KO:K02354]
538536  FZD5; frizzled-5 [KO:K02375]
616913  FZD8; frizzled-8 [KO:K02375]
445418  FZD6; frizzled-6 [KO:K02376]
515323  FZD10; frizzled-10 precursor [KO:K02842]
521364  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
536328  LRP6; low-density lipoprotein receptor-related protein 6 isoform X2 [KO:K03068]
534450  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
530147  BAMBI; BMP and activin membrane-bound inhibitor homolog precursor [KO:K10162]
768234  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
523325  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
539203  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X4 [KO:K02353]
614312  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
505664  FRAT1; proto-oncogene FRAT1 [KO:K03069]
539144  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
282419  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
282420  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
539235  CSNK2B; casein kinase II subunit beta [KO:K03115]
789390  NKD2; protein naked cuticle homolog 2 [KO:K03213]
618586  NKD1; protein naked cuticle homolog 1 [KO:K03213]
101905713  CXXC4; LOW QUALITY PROTEIN: CXXC-type zinc finger protein 4 [KO:K03344]
539639  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
539003  CTNNB1; catenin beta-1 [KO:K02105]
504357  AXIN1; axin-1 [KO:K02157]
511619  AXIN2; axin-2 [KO:K04385]
526572  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
533233  APC; adenomatous polyposis coli protein [KO:K02085]
282684  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
785423  CSNK1B; casein kinase I isoform beta [KO:K08957] [EC:2.7.11.1]
613515  LOW QUALITY PROTEIN: casein kinase I [KO:K08957] [EC:2.7.11.1]
100138998  casein kinase I [KO:K08957] [EC:2.7.11.1]
782690  TCF7; transcription factor 7 [KO:K02620]
515303  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
540481  TCF7L2; transcription factor 7-like 2 [KO:K04491]
535399  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
614630  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
507111  CHD8; chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:3.6.4.12]
534010  SOX17; transcription factor SOX-17 [KO:K04495]
281730  CTBP2; C-terminal-binding protein 2 [KO:K04496]
513131  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496]
505453  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
112446776  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
511475  RUVBL1; ruvB-like 1 [KO:K04499]
540248  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
529146  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
507204  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
511077  MYC; myc proto-oncogene protein [KO:K04377]
280831  JUN; transcription factor AP-1 [KO:K04448]
531389  FOSL1; fos-related antigen 1 [KO:K04502]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
615414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
539163  WISP1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
353106  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
286794  MMP7; matrilysin precursor [KO:K01397] [EC:3.4.24.23]
282705  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
534655  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
100140342  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
100336539  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101906182  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101907097  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
618428  CACYBP; calcyclin-binding protein [KO:K04507]
615427  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
614346  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
515972  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
534072  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
540642  FBXW11; F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
407228  CUL1; cullin-1 [KO:K03347]
518880  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
780968  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
540179  GPC4; glypican-4 precursor [KO:K08110]
783965  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1 [KO:K05122] [EC:2.7.10.1]
785924  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 precursor [KO:K05123] [EC:2.7.10.1]
781353  RYK; tyrosine-protein kinase RYK isoform X2 [KO:K05128] [EC:2.7.10.1]
520544  VANGL2; vang-like protein 2 [KO:K04510]
513056  VANGL1; vang-like protein 1 [KO:K04510]
537192  PRICKLE2; prickle-like protein 2 [KO:K04511]
785152  PRICKLE1; prickle-like protein 1 [KO:K04511]
509780  PRICKLE3; prickle-like protein 3 [KO:K04511]
529698  INVS; inversin [KO:K19626]
783665  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X2 [KO:K04512]
513742  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
338049  RHOA; transforming protein RhoA precursor [KO:K04513]
282041  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 precursor [KO:K07860]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
287026  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
281985  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
515669  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
508888  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
282162  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
525416  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
530719  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
532713  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
286852  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
530401  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
788119  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
KO pathway
ko04310   

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