Species

KNApSAcK Entry

Organism name Sophora angustifolia
Genus Sophora
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sophora
Linked NCBI taxonomy ID 3896
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005000 External link 512 Desmethylicaritin
/ 8-Prenylkaempferol
/ Noranhydroicaritin
/ De-O-methylanhydroicaritin
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL192159
No. 15 No. 15
C00005003 External link 512 Isoanhydroicaritin
No. 15 No. 15
C00008246 External link 512 Isoxanthohumol(Sophora)
CHEMBL492828
4 / 0 / 1 No. 28 No. 14
C00009616 External link 512 Pterocarpin
/ 3-Methoxy-8,9-methylenedioxypterocarpan
CHEMBL21103
CHEMBL242128
CHEMBL1983713
7 / 8 / 10 No. 66 No. 15
C00007099 External link 512 Xanthohumol
CHEMBL253896
6 / 0 / 1 No. 133 No. 13
C00007148 External link 512 Kuraridin
CHEMBL243362
3 / 2 / 2 No. 190 No. 13

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P13866 Sodium/glucose cotransporter 1 Glucose C00007148 C00009616 1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose C00007148 C00009616 1 / 1
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00007099 C00008246 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00007099 C00009616 0 / 0
P17252 Protein kinase C alpha type Alpha C00007099 C00008246 0 / 0
Q04759 Protein kinase C theta type Delta C00007099 C00008246 0 / 1
P27361 Mitogen-activated protein kinase 3 Erk C00007099 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00007099 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00007148 0 / 0
P56817 Beta-secretase 1 A1A C00008246 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009616 4 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00009616 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00009616 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00009616 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#606824 Glucose/galactose malabsorption; ggm P13866
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#233100 Renal glucosuria; glys1 P31639
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (11)

KEGG name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)