PCIDB

Alnus japonica

Species

KNApSAcK Entry

Organism name Alnus japonica
Genus Alnus
Family Betulaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Alnus japonica
Linked NCBI taxonomy ID 109063
Linked level species

Family

Family in NCBI taxonomy Betulaceae
ID 3514

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00031906 External link 512 Isohyperoside
C052072
No. 2 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00005140 External link 512 Afzelin
/ Kaempferol 3-O-alpha-rhamnoside
/ Kaempferol 3-O-alpha-L-rhamnopyranoside
CHEMBL240528
CHEMBL515798
C477954
4 / 2 / 2 No. 2 No. 15
C00001016 External link 512 7-O-Methylacacetin
/ Acacetin 7-methyl ether
/ Genkwanin 4'-methyl ether
/ Apigenin 7,4'-dimethyl ether
/ 5-Hydroxy-4',7-dimethoxyflavone
/ 5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL350958
C044998
1 / 0 / 0 No. 3 No. 15
C00003868 External link 512 Pilloin
/ Luteolin 7,4'-dimethyl ether
/ 5,3'-Dihydroxy-7,4'-dimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL483424
No. 3 No. 15
C00003840 External link 512 Salvigenin
CHEMBL376644
C014049
No. 35 No. 15
C00000604 External link 512 (-)-Secoisolariciresinol
CHEMBL368347
C060283
2 / 1 / 1 1 / 0 No. 282 No. 21
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
CHEMBL120568
D014641
5 / 3 / 3 5 / 0 No. 1073
C00031488 External link 512 1,7-bis(3,4-Dihydroxyphenyl)-5-hydroxy-3-heptanone
CHEMBL455297
1 / 0 / 0 No. 1938 No. 21
C00031066 External link 512 Platyphyllonol-5-O-beta-D-xylopyranoside
CHEMBL2346809
No. 2393
C00031857 External link 512 Hirsutanonol-5-O-beta-D-glucopyranoside
/ (-)-Hirsutanonol-5-O-beta-D-glucopyranoside
No. 2727

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000604 C00005140 1 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002682 C00005374 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000604 C00005140 0 / 1
P15121 Aldose reductase Enzyme C00002682 C00005374 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00005374 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005374 0 / 0
P42858 Huntingtin Unclassified protein C00002682 1 / 1
P17252 Protein kinase C alpha type Alpha C00031488 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005374 1 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005374 1 / 1
P16083 Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme C00005140 0 / 0
P03372 Estrogen receptor NR3A1 C00002682 1 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00002682 1 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00001016 0 / 0
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00005140 1 / 1
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005374 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005374 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005374 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005374 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005374 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000604
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002682
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002682
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002682
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002682
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002682

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#143100 Huntington disease; hd P42858
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#610460 Thiopurine s-methyltransferase deficiency P51580
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (7)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D010146 Pain C00005374