Picea glehnii L.
Species
KNApSAcK Entry
| Organism name | Picea glehnii L. |
|---|---|
| Genus | Picea |
| Family | Pinaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Picea |
|---|---|
| Linked NCBI taxonomy ID | 3328 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Pinaceae |
|---|---|
| ID | 3318 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Spermatophyta |
|---|---|
| ID | 58024 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003444
|
miropinic acid
/ Isopimaric acid / isodextropimaric acid |
CHEMBL512164
|
C115138
|
3 / 1 / 1 | No. 208 | No. 48 |
|
|
|
C00031283
|
Sandaracopimaric acid
/ (-)-Sandaracopimaric acid |
CHEMBL513197
CHEMBL1397211 CHEMBL1410398 CHEMBL1735595 |
C082072
|
14 / 13 / 7 | No. 208 | No. 48 |
|
|
|
C00042455
|
Dehydroabietic acid
|
CHEMBL12850
|
C013913
|
No. 323 | No. 41 |
|
||
|
C00000816
|
beta-Pinene
|
CHEMBL501351
|
C010789
|
No. 476 | No. 35 |
|
||
|
C00000805
|
alpha-Pinene
|
CHEMBL442565
|
C005451
|
3 / 3 / 2 | 0 / 1 | No. 476 | No. 35 |
|
|
C00000823
|
Limonene
|
CHEMBL15799
CHEMBL449062 |
C008281
|
7 / 21 / 48 | 6 / 6 | No. 848 | No. 35 |
|
|
C00000871
|
Abietic acid
/ 7,13-Abietadien-18-oic acid |
CHEMBL71893
CHEMBL1336124 CHEMBL1357151 CHEMBL1514489 CHEMBL1552001 |
C023710
|
18 / 22 / 25 | No. 1536 | No. 40 |
|
|
|
C00000853
|
Myrcene
|
CHEMBL455491
|
C008574
|
3 / 3 / 3 | No. 2285 | No. 34 |
|
|
|
C00003029
|
Camphene
|
CHEMBL506889
CHEMBL510535 |
C019286
|
No. 2460 | No. 35 |
|
||
|
C00000839
|
3-Carene
|
CHEMBL506854
|
C030218
|
No. 2690 | No. 35 |
|
||
|
C00000861
|
Terpinolene
|
CHEMBL454697
|
C027009
|
1 / 0 | No. 3725 |
|
Human Protein / Gene in interactions
40 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000823 C00000871 | 0 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000823 C00031283 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000871 C00031283 | 1 / 1 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00003444 C00031283 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000823 C00000871 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000805 C00000853 | 3 / 2 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00003444 C00031283 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000871 C00031283 | 0 / 1 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000853 | 0 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000823 | 3 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00031283 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000871 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000871 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00003444 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00031283 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00031283 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00031283 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00031283 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00031283 | 1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000871 | 0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000823 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00000853 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000805 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000871 | 3 / 3 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000805 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00031283 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000871 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000823 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000871 | 0 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00031283 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000871 | 4 / 3 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000823 | 7 / 37 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000871 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000871 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00031283 | 1 / 0 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00000871 | 0 / 0 |
| Q16654 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial | Pdhk | C00000871 | 0 / 0 |
| Q15119 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial | Pdhk | C00000871 | 0 / 0 |
| Q15120 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial | Pdhk | C00000871 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000871 | 0 / 0 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000823
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000823
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000823
|
| 3265 | HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 | Harvey rat sarcoma viral oncogene homolog |
C00000823
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00000823
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000823
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000861
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (47)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #300905 | Charcot-marie-tooth disease, x-linked dominant, 6; cmtx6 |
Q15120
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (67)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
6 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003877 | Dermatitis, Contact |
C00000805
C00000823 |
| D008114 | Liver Neoplasms, Experimental |
C00000823
|
| D008107 | Liver Diseases |
C00000823
|
| D007674 | Kidney Diseases |
C00000823
|
| D008569 | Memory Disorders |
C00000823
|
| D013276 | Stomach Ulcer |
C00000823
|