Annona glabra
Species
KNApSAcK Entry
| Organism name | Annona glabra |
|---|---|
| Genus | Annona |
| Family | Annonaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Annona glabra |
|---|---|
| Linked NCBI taxonomy ID | 301703 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Annonaceae |
|---|---|
| ID | 22140 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Natural Activity
List (27)
| Species | Activity |
|---|---|
| Annona glabra L. | Abortifacient |
| Annona glabra L. | Anthelmintic |
| Annona glabra L. | Anticancer |
| Annona glabra L. | Anticancer, breast |
| Annona glabra L. | Anticancer, pancreas |
| Annona glabra L. | Anticarcinomic |
| Annona glabra L. | Antileukemic |
| Annona glabra L. | Antimicrobial |
| Annona glabra L. | Antiproliferant |
| Annona glabra L. | Antitumor |
| Annona glabra L. | Apoptotic |
| Annona glabra L. | Convulsant |
| Annona glabra L. | Cyanogenic |
| Annona glabra L. | Cytotoxic |
| Annona glabra L. | Emetic |
| Annona glabra L. | Fungicide |
| Annona glabra L. | Insecticide |
| Annona glabra L. | Larvicide |
| Annona glabra L. | Molluscicide |
| Annona glabra L. | Narcotic |
| Annona glabra L. | Pectoral |
| Annona glabra L. | Pediculicide |
| Annona glabra L. | Piscicide |
| Annona glabra L. | Poison |
| Annona glabra L. | Schistosomacide |
| Annona glabra L. | Sporicide |
| Annona glabra L. | Vermifuge |
Metabolite list (46)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00040872
|
Annoglacin A
/ (+)-Annoglacin A |
CHEMBL500307
CHEMBL500171 |
No. 6 | No. 70 |
|
|||
|
C00044133
|
Corossolin
/ (+)-Corossolin |
CHEMBL418918
CHEMBL108579 CHEMBL445024 |
No. 6 | No. 70 |
|
|||
|
C00040873
|
Annoglacin B
/ (+)-Annoglacin B |
CHEMBL500307
CHEMBL500171 |
No. 6 | No. 70 |
|
|||
|
C00043268
|
Annonacin
/ (+)-Annonacin |
CHEMBL67945
CHEMBL439797 CHEMBL476498 CHEMBL457276 CHEMBL1992986 |
C053442
|
0 / 1 | No. 6 | No. 70 |
|
|
|
C00030555
|
Itrabin
|
CHEMBL349693
|
No. 6 | No. 70 |
|
|||
|
C00044134
|
Corossolone
|
CHEMBL315283
CHEMBL418831 CHEMBL108962 |
No. 6 | No. 70 |
|
|||
|
C00044174
|
Gigantetrocin A
|
CHEMBL67341
CHEMBL606761 |
No. 6 | No. 70 |
|
|||
|
C00049609
|
Annoglaxin
/ (+)-Annoglaxin |
CHEMBL455022
|
No. 6 | No. 70 |
|
|||
|
C00049604
|
27-Hydroxybullatacin
/ (+)-27-Hydroxybullatacin |
CHEMBL452015
CHEMBL449859 |
No. 6 | No. 70 |
|
|||
|
C00044176
|
Gigantetronenin
|
CHEMBL67564
|
C079193
|
No. 6 | No. 70 |
|
||
|
C00044211
|
Laherradurin
|
CHEMBL160640
|
No. 6 | No. 70 |
|
|||
|
C00044237
|
Molvizarin
|
CHEMBL268185
CHEMBL110333 CHEMBL145222 CHEMBL502162 CHEMBL448258 CHEMBL606053 |
No. 6 | No. 70 |
|
|||
|
C00044247
|
Muricatetrocin B
|
CHEMBL323001
CHEMBL450107 |
No. 6 | No. 70 |
|
|||
|
C00044085
|
Annonacinone
|
CHEMBL110183
CHEMBL134189 CHEMBL450539 |
No. 6 | No. 70 |
|
|||
|
C00027281
|
Anonaine
|
CHEMBL401798
|
C098138
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00027435
|
Nordomesticine
|
No. 20 | No. 4 |
|
||||
|
C00027441
|
Nornuciferine
/ Sanjoinine Ia / Daechualkaloid E |
CHEMBL36496
CHEMBL325416 CHEMBL1164391 |
1 / 0 / 0 | No. 20 | No. 4 |
|
||
|
C00001808
|
Apoglaziovine
/ (-)-Apoglaziovine |
No. 20 | No. 4 |
|
||||
|
C00001872
|
Isocorydine
/ (+)-Isocorydine / L-(+)-Isocorydine / (S)-(+)-Isocorydine |
CHEMBL489525
CHEMBL1376826 |
14 / 7 / 10 | No. 20 | No. 4 |
|
||
|
C00027492
|
Thalicsimidine
|
No. 20 | No. 4 |
|
||||
|
C00025676
|
Norglaucin
/ Norglaucine / (+)-Norglaucine / O,O-Dimethyllaurelliptine |
No. 20 | No. 4 |
|
||||
|
C00000965
|
Glabranin
|
CHEMBL253998
CHEMBL488888 |
5 / 2 / 3 | No. 28 | No. 14 |
|
||
|
C00025241
|
Kikemanin
/ Kikemanine / Corydalmine / Schefferine / (-)-Kikemanine / (-)-Corydalmine |
CHEMBL448891
CHEMBL1209608 CHEMBL2334894 |
C058198
|
5 / 3 / 0 | No. 37 | No. 4 |
|
|
|
C00001878
|
Liriodenine
/ Oxoushinsunine / Spermatheridine |
CHEMBL37736
|
C026980
|
5 / 3 / 1 | No. 74 |
|
||
|
C00025935
|
Lysicamine
/ Oxonuciferine |
CHEMBL510090
|
C069090
|
No. 74 |
|
|||
|
C00026124
|
Dehydrocorydalmine
|
CHEMBL1618061
|
No. 155 | No. 4 |
|
|||
|
C00049865
|
ent-Kaur-15-ene-17,19-diol
|
No. 159 | No. 41 |
|
||||
|
C00049866
|
ent-Kaur-16-en-19-ol
/ (-)-ent-Kaur-16-en-19-ol |
CHEMBL1760139
|
No. 159 | No. 41 |
|
|||
|
C00049852
|
Annoglabasin B
|
CHEMBL490145
CHEMBL1288242 |
No. 203 | No. 41 |
|
|||
|
C00049850
|
16alpha,17-Dihydroxy-ent-kauran-19-oic acid
/ (-)-16alpha,17-Dihydroxy-ent-kauran-19-oic acid |
CHEMBL490353
CHEMBL517155 CHEMBL519801 CHEMBL482613 |
No. 203 | No. 41 |
|
|||
|
C00046613
|
Annoglabasin E
/ (-)-Annoglabasin E |
CHEMBL1288269
|
No. 203 | No. 41 |
|
|||
|
C00028305
|
Glabrin B
|
No. 290 |
|
|||||
|
C00028306
|
Glabrin C
|
No. 290 |
|
|||||
|
C00001910
|
Reticuline
/ (+)-Reticuline |
CHEMBL235212
CHEMBL401501 CHEMBL464734 |
C003298
|
1 / 0 / 0 | No. 345 | No. 4 |
|
|
|
C00040987
|
Glabrin D
|
No. 498 |
|
|||||
|
C00025334
|
trans-Feruloyltyramine
/ N-trans-Feruloyltyramine / trans-N-Feruloyltyramine |
CHEMBL206555
CHEMBL451720 |
1 / 4 / 2 | No. 499 |
|
|||
|
C00027423
|
N-Formylanonaine
/ (-)-N-Formylanonaine |
CHEMBL1170090
|
1 / 4 / 2 | No. 553 |
|
|||
|
C00025272
|
Stepharine
/ (+)-Stepharine |
CHEMBL463957
CHEMBL1975436 |
C009320
|
No. 688 |
|
|||
|
C00027280
|
Annobraine
/ Lettowianthine |
No. 800 |
|
|||||
|
C00027478
|
Romucosine F
|
No. 889 |
|
|||||
|
C00027479
|
Romucosine G
|
CHEMBL208310
|
1 / 1 / 0 | No. 889 |
|
|||
|
C00046611
|
Annoglabasin C
/ (-)-Annoglabasin C |
No. 925 |
|
|||||
|
C00049851
|
Annoglabasin A
/ (-)-Annoglabasin A |
CHEMBL490144
|
No. 925 |
|
||||
|
C00046612
|
Annoglabasin D
/ (-)-Annoglabasin D |
CHEMBL490144
|
No. 925 |
|
||||
|
C00000881
|
Cunabic acid
/ ent-Kaurenoic acid / ent-Kaur-16-en-19-oic acid |
CHEMBL523791
CHEMBL480983 CHEMBL1076299 CHEMBL1968150 |
C051436
|
1 / 0 / 0 | No. 1235 | No. 41 |
|
|
|
C00043266
|
Annoglabayin
/ (-)-Annoglabayin |
No. 4781 |
|
Human Protein / Gene in interactions
29 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00001878 C00027281 C00027441 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000965 C00001872 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000965 C00001872 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000965 C00001872 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000965 C00001872 | 1 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00025334 C00027423 | 4 / 2 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00001878 | 0 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00001878 | 1 / 0 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00001878 | 1 / 1 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00001878 | 1 / 1 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00025241 | 2 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001872 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001872 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001872 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00000965 | 0 / 0 |
| P13726 | Tissue factor | Membrane receptor | C00025241 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001872 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001872 | 3 / 3 |
| P22303 | Acetylcholinesterase | Hydrolase | C00027479 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00025241 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001910 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00025241 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000881 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00025241 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001872 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001872 | 1 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001872 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001872 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001872 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (18)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P14416
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #159900 | Myoclonic dystonia |
P14416
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|