Species

KNApSAcK Entry

Organism name Juniperus communis
Genus Juniperus
Family Cupressaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Juniperus communis
Linked NCBI taxonomy ID 58039
Linked level species

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (23)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004217 External link 512 Scutellarein 6-xyloside
No. 2 No. 15
C00004378 External link 512 6-Hydroxyluteolin 6-xyloside
No. 2 No. 15
C00001098 External link 512 Sciadopitysin
CHEMBL208908
C086243
3 / 3 / 7 No. 34 No. 18
C00006488 External link 512 Bilobetin
CHEMBL378188
2 / 1 / 2 No. 34 No. 18
C00000937 External link 512 Afzelechin
CHEMBL159303
CHEMBL1326092
7 / 4 / 12 No. 52 No. 14
C00008805 External link 512 Epiafzelechin
CHEMBL159303
CHEMBL1326092
7 / 4 / 12 No. 52 No. 14
C00022227 External link 512 (14S)-14,15-Dihydroxy-8(17),13(16)-labdadien-19-oic acid
No. 143
C00022708 External link 512 Isocupressic acid
/ (+)-Isocupressic acid
/ 15-Hydroxy-8(17),13E-labdadien-15-oic acid
CHEMBL511193
C110793
No. 143
C00023285 External link 512 Communic acid
CHEMBL498097
CHEMBL1488779
CHEMBL1731589
13 / 14 / 8 No. 143
C00023286 External link 512 Communol
/ Elliotinol
No. 165
C00020065 External link 512 alpha-Cadinol
/ (-)-alpha-Cadinol
CHEMBL486795
No. 205 No. 38
C00022711 External link 512 3alpha-Hydroxymanool
No. 256 No. 46
C00022712 External link 512 Manool
CHEMBL561922
No. 256 No. 46
C00003106 External link 512 beta-Cadinene
No. 283 No. 39
C00012805 External link 512 (+)-Junenol
/ Eudesm-4(14)-en-6alpha-ol
/ [1S-(1alpha,2beta,4abeta,8aalpha)]-Decahydro-4a-methyl-8-methylene-2-(1-methylethyl)-1-naphthalenol
No. 311
C00002597 External link 512 Deoxypodophyllotoxin
/ (-)-Deoxypodophyllotoxin
CHEMBL63970
CHEMBL149525
CHEMBL152144
CHEMBL255919
CHEMBL519603
CHEMBL476679
CHEMBL1736070
7 / 4 / 2 No. 427 No. 21
C00023302 External link 512 Junicedral
No. 900
C00011067 External link 512 Tricyclene
/ Teresantanane
No. 1225
C00010804 External link 512 Trimenol
/ alpha-Campholenol
/ Campholenic alcohol
No. 4016
C00010805 External link 512 Campholenic aldehyde
/ alpha-Campholenic aldehyde
No. 4016
C00010470 External link 512 Junionone
No. 5781
C00012026 External link 512 Geijeron
/ Geijerone
C002207
No. 6140
C00010978 External link 512 1,4-Dimethyl-3-cyclohexenyl methyl ketone
/ 1-(1,4-Dimethyl-3-cyclohexen-1-yl)ethanone
No. 6772

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000937 C00001098 C00008805 1 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000937 C00002597 C00008805 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00000937 C00008805 C00023285 0 / 0
O00255 Menin Unclassified protein C00000937 C00001098 C00008805 2 / 5
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000937 C00008805 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000937 C00008805 0 / 3
P56817 Beta-secretase 1 A1A C00001098 C00006488 0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00000937 C00008805 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00023285 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002597 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002597 2 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00023285 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00023285 1 / 1
O75496 Geminin Unclassified protein C00002597 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00023285 0 / 0
P39748 Flap endonuclease 1 Enzyme C00023285 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00023285 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00023285 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00023285 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00023285 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002597 0 / 0
P43235 Cathepsin K C1A C00006488 1 / 2
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002597 1 / 0
P06746 DNA polymerase beta Enzyme C00023285 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002597 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00023285 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00023285 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
Q14191
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#265800 Pycnodysostosis P43235
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (23)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00014 Non-small cell lung cancer Q9UM73 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)