Species

KNApSAcK Entry

Organism name Sophora tetraptera
Genus Sophora
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sophora tetraptera
Linked NCBI taxonomy ID 171567
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (21)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009400 External link 512 8-O-Methylretusin
CHEMBL477720
No. 3 No. 15
C00009515 External link 512 Lupalbigenin
/ 5,7,4'-Trihydroxy-6,3'-diprenylisoflavone
CHEMBL463936
No. 14 No. 15
C00000954 External link 512 Senegalensein
/ Lonchocarpol A
/ 6,8-Diprenylnaringenin
CHEMBL477969
CHEMBL1545584
C068505
16 / 26 / 18 No. 19 No. 14
C00019364 External link 512 Kenusanone A
/ 5,7,2',4'-Tetrahydroxy-5'-[(2E)-3,7-dimethyl-2,6-octadienyl]isoflavanone
No. 19 No. 14
C00019520 External link 512 Tetrapterol C
No. 19 No. 14
C00019521 External link 512 Tetrapterol D
/ 5,7,4'-Trihydroxy-3'-((2E)-3,7-dimethyl-2,6-octadienyl)isoflavanone
No. 19 No. 14
C00018976 External link 512 Tetrapterol I
/ 7,4'-Dihydroxy-6,3'-diprenylisoflavanone
No. 19 No. 14
C00018975 External link 512 Tetrapterol H
/ 5,7,2'-Trihydroxy-4'-methoxy-8,5'-diprenylisoflavanone
No. 19 No. 14
C00018974 External link 512 Tetrapterol G
/ 5,7,2',4'-Tetrahydroxy-6,5'-diprenylisoflavanone
No. 19 No. 14
C00019522 External link 512 Tetrapterol E
/ 7,4'-Dihydroxy-3'-((2E)-3,7-dimethyl-2,6-octadienyl)isoflavanone
No. 19 No. 14
C00009802 External link 512 2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran
/ 2',4'-Dihydroxy-5,6-methylenedioxy-2-phenylbenzofuran
CHEMBL524490
No. 27 No. 15
C00008262 External link 512 Lupinifolin
CHEMBL559980
No. 39
C00009561 External link 512 Lespedeol B
No. 39
C00009560 External link 512 Cajanone
CHEMBL1968439
No. 39
C00002546 External link 512 Inermin
/ Maackiain
/ (-)-Maackiain
/ Demethylpterocarpin
/ 3-Hydroxy-8,9-methylenedioxypterocarpan
CHEMBL334918
CHEMBL239047
CHEMBL445279
3 / 2 / 3 No. 66 No. 15
C00010002 External link 512 Isoneorautenol
/ 3-Hydroxy-6'',6''-dimethylpyrano[2'',3'':9,8]pterocarpan
CHEMBL1098729
No. 135 No. 15
C00002212 External link 512 Baptifoline
/ (-)-Baptifoline
C106940
No. 384 No. 3
C00009760 External link 512 Medicagol
/ 3-Hydroxy-8,9-methylenedioxycoumestan
/ 7-Hydroxy-11,12-methylenedioxycoumestan
CHEMBL99941
1 / 0 / 0 No. 473
C00018973 External link 512 Tetrapterol F
No. 1072
C00010010 External link 512 Sophoracarpan A
/ (6R,6aS,11aR)-3-Hydroxy-6,9-dimethoxypterocarpan
No. 1655
C00019519 External link 512 Tetrapterol A
/ 5,7,2'-Trihydroxy-6'',6''-dimethylpyrano[2'',3'':4',5'](1'''-methylphenyl)[3''',4''':4'',5'']isoflavanone
No. 5124

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P13866 Sodium/glucose cotransporter 1 Glucose C00002546 1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose C00002546 1 / 1
P17861 X-box-binding protein 1 Unclassified protein C00000954 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000954 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000954 1 / 1
P06746 DNA polymerase beta Enzyme C00000954 0 / 0
P04062 Glucosylceramidase Enzyme C00000954 6 / 4
P39748 Flap endonuclease 1 Enzyme C00000954 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000954 2 / 0
O75496 Geminin Unclassified protein C00000954 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000954 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000954 7 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002546 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00000954 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000954 4 / 3
P06732 Creatine kinase M-type Enzyme C00009760 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000954 1 / 0
O00255 Menin Unclassified protein C00000954 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000954 1 / 2
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000954 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#606824 Glucose/galactose malabsorption; ggm P13866
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#233100 Renal glucosuria; glys1 P31639
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (21)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)