Helichrysum spp.

• Index
• Plant Species
• Metabolite list (15)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Helichrysum spp.
Genus	Helichrysum
Family	Asteraceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Helichrysum
Linked NCBI taxonomy ID	59430
Linked level	genus

Family

Family in NCBI taxonomy	Asteraceae
ID	4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (15)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00004588	3,5-Dihydroxy-6,7,8-trimethoxyflavone / 3,5-Dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-1-benzopyran-4-one	CHEMBL1416487		8 / 13 / 7		No. 3	No. 15
C00004684	Axillarin / Quercetagetin 3,6-dimethyl ether / 3,6-Dimethoxy-5,7,3',4'-tetrahydroxyflavone / 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one	CHEMBL487810	C056669	1 / 1 / 1		No. 3	No. 15
C00003879	Xanthomicrol / 5-Hydroxy-2-(4-hydroxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one	CHEMBL476121	C462036			No. 3	No. 15
C00003926	5,7,3',4'-Tetrahydroxy-6,8-dimethoxyflavone					No. 3	No. 15
C00004585	3,5,7-Trihydroxy-6,8-dimethoxyflavone / 3,5,7-Trihydroxy-6,8-dimethoxy-2-phenyl-4H-1-benzopyran-4-one					No. 3	No. 15
C00004544	3-O-Methylalnusin / Alnusin 3-methyl ether / 5,7-Dihydroxy-3,6-dimethoxyflavone / 5,7-Dihydroxy-3,6-dimethoxy-2-phenyl-4H-1-benzopyran-4-one					No. 3	No. 15
C00003927	Sideritiflavone / 5,3',4'-Trihydroxy-6,7,8-trimethoxyflavone / 2-(3,4-Dihydroxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one	CHEMBL312790				No. 3	No. 15
C00004793	5,3',4'-Trihydroxy-3,6,7,8-tetramethoxyflavone / 5,4',5'-Trihydroxy-3,6,7,8-tetramethoxyflavone / 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-1-benzopyran-4-one	CHEMBL471084	C037412			No. 8	No. 15
C00008204	Floribundoside	CHEMBL2152489 CHEMBL2152490				No. 12	No. 14
C00000992	Pinocembrin	CHEMBL70518 CHEMBL399910 CHEMBL399249	C016063	18 / 23 / 23	5 / 0	No. 25	No. 14
C00008143	Alpinetin / (-)-Alpinetin	CHEMBL427218 CHEMBL254825				No. 25	No. 14
C00008171	Isoglabranin / 6-Prenylpinocembrin / 5,7-Dihydroxy-6-C-prenylflavanone	CHEMBL2143430 CHEMBL2165236		1 / 0 / 0		No. 28	No. 14
C00006935	Cardamomin	CHEMBL378104		13 / 18 / 14		No. 92	No. 13
C00006934	Pinostrobin chalcone / 2',6'-Dihydroxy-4'-methoxychalcone	CHEMBL317221 CHEMBL1705800		3 / 1 / 2		No. 92	No. 13
C00002399	6-Hydroxytremetone					No. 1831

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10636	Microtubule-associated protein tau	Unclassified protein	C00000992 C00004588 C00006935	4 / 3
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000992 C00004588 C00006935	7 / 3
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000992 C00006934	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000992 C00006934	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000992 C00006935	1 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000992 C00004588	0 / 0
O00255	Menin	Unclassified protein	C00000992 C00006935	2 / 5
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00004588 C00008171	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000992 C00006934	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00000992	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00000992	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00004588	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00006935	2 / 0
O75496	Geminin	Unclassified protein	C00006935	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00004684	1 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00000992	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00000992	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00006935	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00000992	4 / 4
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000992	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000992	3 / 3
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000992	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00004588	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000992	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00006935	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00006935	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00006935	0 / 0
P22001	Potassium voltage-gated channel subfamily A member 3	KCNA, Kv1.x (Shaker)	C00006935	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00006935	1 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00004588	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00004588	1 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00006935	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000992	1 / 0

5 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000992
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000992
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00000992
6818	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1)	C00000992
7052	TGM2, G-ALPHA-h, GNAH, TG2, TGC	transglutaminase 2 (EC:2.3.2.13)	C00000992

Related Diseases

Diseases related to proteins in ChEMBL interactions