PCIDB

Annona cherimolia

Species

KNApSAcK Entry

Organism name Annona cherimolia
Genus Annona
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Annona
Linked NCBI taxonomy ID 13336
Linked level genus

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (38)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001301 External link 512 Asimicin
CHEMBL13710
CHEMBL61332
CHEMBL68179
CHEMBL142918
CHEMBL453675
CHEMBL503360
CHEMBL453496
CHEMBL454744
CHEMBL501110
CHEMBL451402
CHEMBL506914
CHEMBL446085
CHEMBL509939
CHEMBL508255
CHEMBL499188
CHEMBL1996175
CHEMBL1999460
CHEMBL2007355
C061022
No. 6 No. 70
C00001323 External link 512 Squamocin
CHEMBL41177
CHEMBL502366
CHEMBL453405
CHEMBL452936
C059660
No. 6 No. 70
C00049422 External link 512 Annocherin
/ (+)-Annocherin
CHEMBL445446
No. 6 No. 70
C00045640 External link 512 Annomolin
/ (-)-Annomolin
CHEMBL452581
No. 6 No. 70
C00045639 External link 512 Annocherimolin
/ (-)-Annocherimolin
CHEMBL447154
No. 6 No. 70
C00044519 External link 512 Annomolon B
CHEMBL450529
No. 6 No. 70
C00044518 External link 512 Annomolon A
CHEMBL454755
No. 6 No. 70
C00044437 External link 512 34-epi-Annomolon B
CHEMBL450529
No. 6 No. 70
C00044436 External link 512 34-epi-Annomolon A
CHEMBL454755
No. 6 No. 70
C00044273 External link 512 Otivarin
No. 6 No. 70
C00044237 External link 512 Molvizarin
CHEMBL268185
CHEMBL110333
CHEMBL145222
CHEMBL502162
CHEMBL448258
CHEMBL606053
No. 6 No. 70
C00044211 External link 512 Laherradurin
CHEMBL160640
No. 6 No. 70
C00044209 External link 512 Jetein
No. 6 No. 70
C00044203 External link 512 Isomolvizarin 2
No. 6 No. 70
C00044202 External link 512 Isomolvizarin 1
No. 6 No. 70
C00044119 External link 512 Cherimolin 2
CHEMBL25650
CHEMBL68350
CHEMBL345841
CHEMBL1971856
CHEMBL1997997
No. 6 No. 70
C00040367 External link 512 Squamostatin A
CHEMBL499780
CHEMBL447119
CHEMBL506139
CHEMBL1818440
No. 6 No. 70
C00030795 External link 512 Motrilin
CHEMBL66691
CHEMBL362807
No. 6 No. 70
C00030555 External link 512 Itrabin
CHEMBL349693
No. 6 No. 70
C00029945 External link 512 Cherimolin
/ Cherimolin-1
/ Cherimolin 1
CHEMBL25650
CHEMBL68350
CHEMBL345841
CHEMBL1971856
CHEMBL1997997
No. 6 No. 70
C00029664 External link 512 Almunequin
/ (+)-Alumunequin
CHEMBL499780
CHEMBL447119
CHEMBL506139
CHEMBL1818440
No. 6 No. 70
C00027576 External link 512 Nuciferine
/ D-(-)-Nuciferine
CHEMBL464529
C008692
0 / 1 No. 20 No. 4
C00001806 External link 512 Anolobine
/ (-)-Anolobine
CHEMBL257746
No. 20 No. 4
C00027281 External link 512 Anonaine
CHEMBL401798
C098138
1 / 0 / 0 No. 20 No. 4
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00001928 External link 512 Xylopine
/ (-)-Xylopine
CHEMBL227689
CHEMBL452201
C062700
No. 20 No. 4
C00025231 External link 512 Asimilobine
/ (-)-Asimilobine
CHEMBL389271
CHEMBL469423
C054614
1 / 1 / 0 No. 20 No. 4
C00025991 External link 512 O-Nornuciferine
/ (-)-Nornuciferine
/ (-)-N-Methylasimilobine
CHEMBL2316499
No. 20 No. 4
C00025827 External link 512 Corydine
/ Glaucentrin
/ (+)-Corydine
/ Glaucentrine
CHEMBL489524
CHEMBL2002847
C067341
1 / 0 / 0 No. 20 No. 4
C00026117 External link 512 Corypalmine
/ (-)-Corypalmine
CHEMBL2334885
CHEMBL2334886
4 / 3 / 0 No. 37 No. 4
C00026150 External link 512 Tetrahydropalmatine
/ dl-Tetrahydropalmatine
/ (+/-)-Tetrahydropalmatine
CHEMBL187892
CHEMBL487182
CHEMBL2334889
8 / 5 / 2 No. 37 No. 4
C00026108 External link 512 Aequaline
/ Discretamine
/ (-)-Discretamine
CHEMBL320397
CHEMBL2334883
7 / 3 / 0 No. 37 No. 4
C00025935 External link 512 Lysicamine
/ Oxonuciferine
CHEMBL510090
C069090
No. 74
C00025319 External link 512 Oxoxylopin
/ Oxoxylopine
/ Lanuginosine
CHEMBL389400
1 / 4 / 2 No. 74
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00027444 External link 512 Michelalbine
/ Norushinsunine
CHEMBL464657
CHEMBL1618042
No. 553
C00001862 External link 512 Glaziovine
/ L-Glaziovine
/ N-Methylcrotsparine
/ L-(-)-N-Methylcrotsparine
CHEMBL1980854
C007847
No. 688

Human Protein / Gene in interactions

38 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21728 D(1A) dopamine receptor Dopamine receptor C00026108 C00026117 C00026150 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00026108 C00026117 C00026150 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00026108 C00026117 C00026150 2 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00026108 C00026117 C00026150 0 / 0
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001878 C00027281 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001869 C00026150 0 / 1
P03372 Estrogen receptor NR3A1 C00026150 1 / 1
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001869 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00025827 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001869 0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00026108 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00026150 1 / 0
P00734 Prothrombin S1A C00025319 4 / 2
P13726 Tissue factor Membrane receptor C00026150 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 2 / 2
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P22303 Acetylcholinesterase Hydrolase C00025231 1 / 0
P29466 Caspase-1 C14 C00001869 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P55210 Caspase-7 C14 C00001869 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001869 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001869 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001869 4 / 3
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00026108 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00026108 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001869 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
O00255 Menin Unclassified protein C00001869 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001869 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P14416
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#159900 Myoclonic dystonia P14416
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#112100 Yt blood group antigen P22303

KEGG DISEASE (58)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002375 Catalepsy C00027576