Species

KNApSAcK Entry

Organism name Lonchocarpus costaricensis
Genus Lonchocarpus
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lonchocarpus costaricensis
Linked NCBI taxonomy ID 1127057
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008184 External link 512 5-Methoxy-7-prenyloxy-8-C-prenylflavanone
No. 19 No. 14
C00004047 External link 512 Isopongaflavone
/ Candidin (Tephrosia)
/ 5-Methoxy-8,8-dimethyl-2-phenyl-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one
CHEMBL454843
10 / 4 / 1 No. 24 No. 15
C00008385 External link 512 Candidone
CHEMBL454844
No. 28 No. 14
C00008173 External link 512 Pongachin
/ Obovatin methyl ether
/ 5-Methoxyisolonchocarpin
No. 127 No. 14
C00007001 External link 512 Demethylpraecanson B
No. 130
C00007085 External link 512 Ovalichalcone
No. 133 No. 13
C00002035 External link 512 1-Deoxymannojirimycin
/ (-)-Deoxymannojirimycin
CHEMBL11510
CHEMBL65131
CHEMBL307429
CHEMBL84844
CHEMBL110458
CHEMBL369297
CHEMBL179085
CHEMBL176206
CHEMBL179130
CHEMBL179347
CHEMBL179409
CHEMBL176021
CHEMBL369046
CHEMBL176209
CHEMBL368121
CHEMBL175901
CHEMBL1337303
33 / 27 / 27 No. 786 No. 1
C00008185 External link 512 7-Prenyloxy-8-C-(3-hydroxy-3-methyl-trans-buten-1-yl)flavanone
No. 1115

Human Protein / Gene in interactions

42 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00002035 C00004047 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00002035 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002035 0 / 0
P04062 Glucosylceramidase Enzyme C00002035 6 / 4
Q14697 Neutral alpha-glucosidase AB Enzyme C00002035 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002035 1 / 1
Q9H227 Cytosolic beta-glucosidase Enzyme C00002035 0 / 0
P35573 Glycogen debranching enzyme Enzyme C00002035 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00002035 3 / 1
P16278 Beta-galactosidase Enzyme C00002035 4 / 6
P04066 Tissue alpha-L-fucosidase Enzyme C00002035 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002035 0 / 1
P23458 Tyrosine-protein kinase JAK1 Jakb C00002035 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002035 1 / 0
P39748 Flap endonuclease 1 Enzyme C00004047 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00004047 2 / 0
O75496 Geminin Unclassified protein C00004047 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00004047 0 / 0
P14410 Sucrase-isomaltase, intestinal Enzyme C00002035 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00004047 0 / 0
P06280 Alpha-galactosidase A Enzyme C00002035 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00004047 0 / 0
O00462 Beta-mannosidase Enzyme C00002035 1 / 2
Q9HCG7 Non-lysosomal glucosylceramidase Enzyme C00002035 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002035 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00002035 0 / 0
P09848 Lactase-phlorizin hydrolase Enzyme C00002035 1 / 1
Q16739 Ceramide glucosyltransferase Transferase C00002035 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002035 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002035 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002035 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002035 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00004047 0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase C00002035 0 / 0
O43280 Trehalase Enzyme C00002035 0 / 0
O00754 Lysosomal alpha-mannosidase Enzyme C00002035 1 / 2
Q6P4F1 Alpha-(1,3)-fucosyltransferase 10 Enzyme C00002035 0 / 0
Q9Y2E5 Epididymis-specific alpha-mannosidase Enzyme C00002035 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00004047 1 / 0
O00255 Menin Unclassified protein C00002035 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002035 1 / 2
Q13148 TAR DNA-binding protein 43 Unclassified protein C00004047 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#230000 Fucosidosis P04066
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#232400 Glycogen storage disease iii P35573
#230500 Gm1-gangliosidosis, type i P16278
#230600 Gm1-gangliosidosis, type ii P16278
#230650 Gm1-gangliosidosis, type iii P16278
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#223000 Lactase deficiency, congenital P09848
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248500 Mannosidosis, alpha b, lysosomal; mansa O00754
#248510 Mannosidosis, beta a, lysosomal; mansb O00462
#253010 Mucopolysaccharidosis type ivb P16278
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#168600 Parkinson disease, late-onset; pd P04062
#614409 Spastic paraplegia 46, autosomal recessive; spg46 Q9HCG7
#222900 Sucrase-isomaltase deficiency, congenital; csid P14410
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (28)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00140 beta-Mannosidosis O00462 (related)
H00422 Glycoproteinoses O00462 (related)
O00754 (related)
P04066 (related)
P16278 (related)
H00139 alpha-Mannosidosis O00754 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
P16278 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00141 Fucosidosis P04066 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00116 Congenital lactase deficiency P09848 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
P35573 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00115 Congenital sucrase-isomaltase deficiency P14410 (related)
H00123 Mucopolysaccharidosis type IV (MPS4) P16278 (related)
H00276 Galactosialidosis P16278 (related)
H00281 GM1 gangliosidosis P16278 (related)
H00421 Mucopolysaccharidosis (MPS) P16278 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)