Paeonia suffruticosa
Species
KNApSAcK Entry
| Organism name | Paeonia suffruticosa |
|---|---|
| Genus | Paeonia |
| Family | Paeoniaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Paeonia suffruticosa |
|---|---|
| Linked NCBI taxonomy ID | 45171 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Paeoniaceae |
|---|---|
| ID | 24943 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (10)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005374
|
Quercetin
|
CHEMBL82242
CHEMBL479232 CHEMBL1437696 |
C012526
|
14 / 2 / 2 | 2 / 1 | No. 2 | No. 15 |
|
|
C00049821
|
Mudanpinoic acid A
/ (+)-Mudanpinoic acid A |
No. 13 | No. 51 |
|
||||
|
C00003741
|
Betulinic acid
|
CHEMBL269277
CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635 |
C002070
|
34 / 17 / 14 | 10 / 2 | No. 23 | No. 51 |
|
|
C00002706
|
Paeonoside
|
CHEMBL1079881
|
No. 45 | No. 72 |
|
|||
|
C00002705
|
Paeonolide
|
CHEMBL1080061
|
No. 128 | No. 72 |
|
|||
|
C00049820
|
Mudanoside B
/ (-)-Mudanoside B |
No. 267 |
|
|||||
|
C00049844
|
trans-Caffeic acid stearyl ester
|
CHEMBL471797
|
No. 447 |
|
||||
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00003011
|
Paeoniflorin
|
CHEMBL1078549
CHEMBL1397567 CHEMBL1972762 |
C015423
|
4 / 4 / 8 | 3 / 2 | No. 1566 |
|
|
|
C00000207
|
Benzoic acid
|
CHEMBL541
|
D019817
|
97 / 39 / 33 | 24 / 1 | No. 2192 |
|
Human Protein / Gene in interactions
142 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000207 C00003741 | 1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003741 C00005374 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000207 C00003741 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000207 C00003741 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00000207 C00003011 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000207 C00003741 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00003741 C00005374 | 1 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003741 C00019308 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00003741 C00005374 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003011 C00005374 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000207 C00003741 | 0 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00003741 C00019308 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000207 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000207 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000207 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000207 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000207 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000207 | 2 / 2 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003741 | 0 / 0 |
| Q99489 | D-aspartate oxidase | Enzyme | C00000207 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003741 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003741 | 11 / 10 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00019308 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000207 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005374 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000207 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000207 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000207 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000207 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000207 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000207 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000207 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000207 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000207 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00003741 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000207 | 0 / 0 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000207 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000207 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000207 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000207 | 0 / 0 |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | C00003741 | 0 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005374 | 0 / 0 |
| P14920 | D-amino-acid oxidase | Enzyme | C00000207 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000207 | 1 / 8 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003741 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003741 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000207 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000207 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000207 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000207 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000207 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000207 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000207 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000207 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000207 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000207 | 1 / 0 |
| P08246 | Neutrophil elastase | S1A | C00000207 | 2 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000207 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003741 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005374 | 0 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00003741 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003741 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000207 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000207 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000207 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000207 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000207 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000207 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000207 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000207 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000207 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000207 | 2 / 2 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000207 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000207 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000207 | 1 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000207 | 0 / 3 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000207 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000207 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000207 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003741 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000207 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000207 | 0 / 0 |
| Q9GZT4 | Serine racemase | Enzyme | C00000207 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003741 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000207 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005374 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003741 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00019308 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000207 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000207 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000207 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000207 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000207 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000207 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000207 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000207 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000207 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000207 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000207 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003741 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003741 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000207 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000207 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000207 | 2 / 1 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003741 | 0 / 0 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00003741 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000207 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003741 | 2 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000207 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000207 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000207 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000207 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000207 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000207 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000207 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000207 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000207 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003741 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00003741 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000207 | 0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00005374 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000207 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005374 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005374 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005374 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000207 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000207 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000207 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000207 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000207 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000207 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000207 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000207 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00019308 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005374 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003741 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00003741 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00003011 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003011 | 1 / 2 |
| Q9UBT2 | SUMO-activating enzyme subunit 2 | Enzyme | C00003741 | 0 / 0 |
| Q9UBE0 | SUMO-activating enzyme subunit 1 | Unclassified protein | C00003741 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005374 | 0 / 0 |
39 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003741
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003741
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00003741
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003741
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003741
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003741
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003741
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003741
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003741
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003741
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00005374
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00005374
|
| 664 | BNIP3, NIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 |
C00003011
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00003011
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003011
|
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00000207
|
| 57016 | AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI | aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) |
C00000207
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00000207
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00000207
|
| 2235 | FECH, EPP, FCE | ferrochelatase (EC:4.99.1.1) |
C00000207
|
| 2512 | FTL, NBIA3 | ferritin, light polypeptide |
C00000207
|
| 2539 | G6PD, G6PD1 | glucose-6-phosphate dehydrogenase (EC:1.1.1.49) |
C00000207
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00000207
|
| 2730 | GCLM, GLCLR | glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) |
C00000207
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00000207
|
| 2938 | GSTA1, GST2, GSTA1-1, GTH1 | glutathione S-transferase alpha 1 (EC:2.5.1.18) |
C00000207
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000207
|
| 4097 | MAFG, hMAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G |
C00000207
|
| 4199 | ME1, HUMNDME, MES | malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) |
C00000207
|
| 4489 | MT1A, MT1, MT1S, MTC | metallothionein 1A |
C00000207
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00000207
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00000207
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00000207
|
| 5226 | PGD, 6PGD | phosphogluconate dehydrogenase (EC:1.1.1.44) |
C00000207
|
| 22949 | PTGR1, LTB4DH, PGR1, ZADH3 | prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) |
C00000207
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00000207
|
| 140809 | SRXN1, C20orf139, Npn3, SRX, SRX1 | sulfiredoxin 1 (EC:1.8.98.2) |
C00000207
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00000207
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000207
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (61)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (54)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D008103 | Liver Cirrhosis |
C00003741
|
| D008545 | Melanoma |
C00003741
|
| D002493 | Central Nervous System Diseases |
C00019308
|
| D003072 | Cognition Disorders |
C00019308
|
| D013118 | Spinal Cord Diseases |
C00019308
|
| D010146 | Pain |
C00005374
|
| D000647 | Amnesia |
C00003011
|
| D007022 | Hypotension |
C00003011
|
| D003877 | Dermatitis, Contact |
C00000207
|