Ruta chalepensis L.
Species
KNApSAcK Entry
| Organism name | Ruta chalepensis L. |
|---|---|
| Genus | Ruta |
| Family | Rutaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ruta chalepensis |
|---|---|
| Linked NCBI taxonomy ID | 452790 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Rutaceae |
|---|---|
| ID | 23513 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002137
|
Arborinine
|
CHEMBL349609
|
C022784
|
1 / 0 / 0 | No. 257 | No. 7 |
|
|
|
C00002177
|
Kokusaginine
|
CHEMBL278779
|
9 / 7 / 3 | No. 368 | No. 7 |
|
||
|
C00002151
|
Dictamine
/ Dictamnine |
CHEMBL22533
|
C026398
|
No. 368 | No. 7 |
|
||
|
C00002453
|
Byakangelicin
/ (+)-Byakangelicin |
CHEMBL508648
|
C434685
|
5 / 2 / 0 | No. 579 | No. 25 |
|
|
|
C00000583
|
Isopimpinellin
|
CHEMBL140796
|
C015304
|
9 / 3 / 4 | 2 / 0 | No. 606 | No. 25 |
|
|
C00002505
|
Xanthyletin
|
CHEMBL303846
|
C020814
|
29 / 43 / 58 | No. 750 | No. 25 |
|
|
|
C00000297
|
Psoralen
|
CHEMBL164660
|
D005363
|
12 / 6 / 6 | 0 / 5 | No. 1282 | No. 25 |
|
|
C00000575
|
Bergaptan
|
CHEMBL24171
|
C022909
|
22 / 22 / 17 | 0 / 3 | No. 1282 | No. 25 |
|
|
C00002495
|
Rutamarin
|
CHEMBL1917738
|
C022850
|
No. 2443 | No. 25 |
|
||
|
C00035561
|
Chalepin
|
CHEMBL67815
|
C031533
|
1 / 0 / 0 | No. 2443 | No. 25 |
|
|
|
C00007240
|
Xanthoxin
|
No. 4321 |
|
Human Protein / Gene in interactions
53 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000297 C00000575 C00000583 C00002177 C00002453 C00002505 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000297 C00000575 C00002177 C00002453 C00002505 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000297 C00000575 C00000583 C00002453 C00002505 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000575 C00000583 C00002177 C00002505 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000297 C00000575 C00002505 | 3 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000297 C00000575 C00000583 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000297 C00000575 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000297 C00000575 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00000583 C00002505 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000583 C00002505 | 2 / 2 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000583 C00002177 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002505 C00035561 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002453 C00002505 | 1 / 0 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000297 C00000575 | 1 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000583 C00002177 | 1 / 1 |
| P37840 | Alpha-synuclein | Unclassified protein | C00002177 C00002505 | 4 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000575 C00002505 | 7 / 3 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002177 C00002505 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000575 C00002505 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000297 C00000575 | 0 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000297 C00000575 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000297 | 0 / 0 |
| P16389 | Potassium voltage-gated channel subfamily A member 2 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002453 | 1 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002505 | 2 / 2 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002505 | 1 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00000575 | 1 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000583 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002177 | 2 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002505 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002505 | 4 / 2 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002505 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002505 | 1 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000575 | 3 / 2 |
| P17658 | Potassium voltage-gated channel subfamily A member 6 | K | C00000575 | 0 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002505 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002505 | 0 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002505 | 0 / 0 |
| P22001 | Potassium voltage-gated channel subfamily A member 3 | KCNA, Kv1.x (Shaker) | C00000575 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002505 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002505 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002505 | 1 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000297 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002137 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002505 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002177 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002505 | 4 / 3 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002505 | 4 / 1 |
| P10275 | Androgen receptor | NR3C4 | C00000575 | 3 / 4 |
| P22460 | Potassium voltage-gated channel subfamily A member 5 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
| P48547 | Potassium voltage-gated channel subfamily C member 1 | K | C00000575 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002505 | 7 / 37 |
| Q09470 | Potassium voltage-gated channel subfamily A member 1 | KCNA, Kv1.x (Shaker) | C00000575 | 1 / 1 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000583
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000583
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (59)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #612240 | Atrial fibrillation, familial, 7; atfb7 |
P22460
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #160120 | Episodic ataxia, type 1; ea1 |
Q09470
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (68)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00731 | Atrial fibrillation |
P22460
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00749 | Episodic ataxias |
Q09470
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D011565 | Psoriasis |
C00000575
C00000297 |
| D000647 | Amnesia |
C00000297
|
| D006505 | Hepatitis |
C00000575
|
| D010787 | Photosensitivity Disorders |
C00000575
|
| D002280 | Carcinoma, Basal Cell |
C00000297
|
| D017484 | Dermatitis, Phototoxic |
C00000297
|
| D056486 | Drug-Induced Liver Injury |
C00000297
|