Species

KNApSAcK Entry

Organism name Cudrania tricuspidata
Genus Cudrania
Family Moraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Maclura tricuspidata
Linked NCBI taxonomy ID 210328
Linked level species

Family

Family in NCBI taxonomy Moraceae
ID 3487

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (28)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00036965 External link 512 Cudraxanthone F
No. 14 No. 15
C00038877 External link 512 Cudratricusxanthone K
CHEMBL228335
No. 14 No. 15
C00019057 External link 512 Isoerysenegalensein E
/ 5,7,4'-Trihydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-8-prenylisoflavone
CHEMBL559714
No. 14 No. 15
C00013414 External link 512 Cudraflavone D
/ 2-[2,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
No. 14 No. 15
C00013412 External link 512 Cudraflavone C
/ 2',4',5,7-Tetrahydroxy-3,6-bis(3-methyl-2-butenyl)flavone
/ 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
CHEMBL485777
No. 14 No. 15
C00019062 External link 512 Erysenegalensein E
CHEMBL557493
No. 14 No. 15
C00009516 External link 512 6,8-Diprenylgenistein
/ 8-(gamma,gamma-Dimethylallyl)wighteone
/ 5,7,4'-Trihydroxy-6,8-diprenylisoflavone
CHEMBL494252
12 / 14 / 11 No. 14 No. 15
C00039430 External link 512 Isocudraxanthone K
CHEMBL390040
No. 18 No. 15
C00036963 External link 512 Cudraxanthone B
No. 18 No. 15
C00036966 External link 512 Cudraxanthone K
No. 18 No. 15
C00030035 External link 512 Cudraflavone A
CHEMBL230558
No. 18 No. 15
C00004053 External link 512 Cycloartocarpesin
/ 8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
CHEMBL221908
2 / 0 / 0 No. 24 No. 15
C00038874 External link 512 Cudraflavanone B
CHEMBL460437
No. 28 No. 14
C00008332 External link 512 Cudraflavanone A
CHEMBL220746
2 / 0 / 0 No. 39
C00009945 External link 512 Senegalensin
CHEMBL565072
No. 47 No. 15
C00036964 External link 512 Cudraxanthone E
No. 47 No. 15
C00038882 External link 512 Cudraxanthone L
CHEMBL197916
2 / 0 / 0 No. 47 No. 15
C00038875 External link 512 Cudratricusxanthone A
CHEMBL200640
No. 47 No. 15
C00038876 External link 512 Cudratricusxanthone J
CHEMBL395246
No. 47 No. 15
C00047150 External link 512 7,8]isoflavone
/ (+)-5,4'-Dihydroxy-6-(3'-methylbut-2''-enyl)-2'''-(4'''-hydroxy-4'''-methylethyl)-3'''-methoxydihydrofurano-[4''',5'''
CHEMBL557289
No. 47 No. 15
C00038880 External link 512 Cudraxanthone C
CHEMBL200429
2 / 0 / 0 No. 47 No. 15
C00038879 External link 512 Cudratricusxanthone M
CHEMBL397206
No. 47 No. 15
C00002554 External link 512 Orobol
/ Santol
/ Norsantal
/ 5,7,3',4'-Tetrahydroxyisoflavone
CHEMBL241609
C059811
1 / 1 / 8 No. 71 No. 15
C00038878 External link 512 Cudratricusxanthone L
CHEMBL228337
No. 425 No. 15
C00008657 External link 512 Gericudranin E
CHEMBL454853
No. 1068
C00008658 External link 512 Gericudranin D
CHEMBL510170
No. 1068
C00047152 External link 512 5,7,4'-Trihydroxy-8-p-hydroxybenzyldihydroflavonol
CHEMBL563192
No. 1068
C00047151 External link 512 6,7] isoflavone
/ 5,4'-Dihydroxy-8-(3''-methylbut-2''-enyl)-2'''-(4'''-hydroxy-4'''-methylethyl) furano[4''',5'''
CHEMBL559517
No. 3921

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35610 Sterol O-acyltransferase 1 Enzyme C00004053 C00008332 C00038880 C00038882 0 / 0
O75908 Sterol O-acyltransferase 2 Enzyme C00004053 C00008332 C00038880 C00038882 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00009516 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002554 1 / 8
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00009516 2 / 0
O75496 Geminin Unclassified protein C00009516 0 / 0
Q99700 Ataxin-2 Unclassified protein C00009516 1 / 1
P04062 Glucosylceramidase Enzyme C00009516 6 / 4
P28482 Mitogen-activated protein kinase 1 Erk C00009516 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00009516 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00009516 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009516 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00009516 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00009516 1 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00009516 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (19)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)