Species

KNApSAcK Entry

Organism name Macrococculus pomiferus
Genus Macrococculus
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Macrococculus pomiferus
Linked NCBI taxonomy ID 1085094
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00035775 External link 512 (-)-5'-Methoxyyatein
CHEMBL490527
No. 223 No. 21
C00002598 External link 512 Yatein
/ (-)-Yatein
/ (-)-Deoxypodorhizone
/ Dihydroanhydropodorhizol
CHEMBL345590
CHEMBL471067
CHEMBL2021357
C452802
2 / 1 / 1 No. 223 No. 21
C00002597 External link 512 Deoxypodophyllotoxin
/ (-)-Deoxypodophyllotoxin
CHEMBL63970
CHEMBL149525
CHEMBL152144
CHEMBL255919
CHEMBL519603
CHEMBL476679
CHEMBL1736070
7 / 4 / 2 No. 427 No. 21
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00035789 External link 512 2,6-Dimethoxyhydroquinone
No. 856
C00002657 External link 512 p-Formylphenol
/ 4-Hydroxybenzaldehyde
/ p-Hydroxybenzaldehyde
CHEMBL14193
C011483
3 / 2 / 2 No. 2076
C00029834 External link 512 Vomifoliol
/ Blumenol A
/ (+)-Blumenol A
/ Roseoside aglycon
CHEMBL463088
No. 3492

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002597 C00002598 0 / 1
O75496 Geminin Unclassified protein C00002597 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002597 1 / 1
P06746 DNA polymerase beta Enzyme C00019308 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00019308 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002657 1 / 1
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00002657 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002597 2 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019308 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019308 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002597 0 / 0
P00734 Prothrombin S1A C00019308 4 / 2
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002657 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002598 1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002597 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002597 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#608902 Drug metabolism, poor, cyp2d6-related P10635
#613163 Gaba-transaminase deficiency P80404
#137800 Glioma susceptibility 1; glm1 O75874
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (6)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00036 Osteosarcoma P08684 (marker)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308