Tetraclinis articulata
Species
KNApSAcK Entry
| Organism name | Tetraclinis articulata |
|---|---|
| Genus | Tetraclinis |
| Family | Cupressaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Tetraclinis articulata |
|---|---|
| Linked NCBI taxonomy ID | 13717 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cupressaceae |
|---|---|
| ID | 3367 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Spermatophyta |
|---|---|
| ID | 58024 |
Natural Activity
List (2)
| Species | Activity |
|---|---|
| Tetraclinis articulata (Vahl) Mast. | Abortifacient |
| Tetraclinis articulata (Vahl) Mast. | Antibacterial |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003112
|
Cedrol
/ (+)-Cedrol / alpha-Cedrol |
CHEMBL1592444
CHEMBL1974890 |
C078669
|
5 / 14 / 11 | No. 161 | No. 38 |
|
|
|
C00031283
|
Sandaracopimaric acid
/ (-)-Sandaracopimaric acid |
CHEMBL513197
CHEMBL1397211 CHEMBL1410398 CHEMBL1735595 |
C082072
|
14 / 13 / 7 | No. 208 | No. 48 |
|
|
|
C00003444
|
miropinic acid
/ Isopimaric acid / isodextropimaric acid |
CHEMBL512164
|
C115138
|
3 / 1 / 1 | No. 208 | No. 48 |
|
|
|
C00040508
|
Totarol
/ (+)-Totarol |
CHEMBL487602
CHEMBL1474684 CHEMBL1999971 |
C078548
|
20 / 19 / 47 | No. 359 | No. 40 |
|
|
|
C00003426
|
Ferruginol
|
CHEMBL197308
|
No. 359 | No. 40 |
|
|||
|
C00002597
|
Deoxypodophyllotoxin
/ (-)-Deoxypodophyllotoxin |
CHEMBL63970
CHEMBL149525 CHEMBL152144 CHEMBL255919 CHEMBL519603 CHEMBL476679 CHEMBL1736070 |
7 / 4 / 2 | No. 427 | No. 21 |
|
||
|
C00040509
|
Totarolone
|
No. 760 |
|
|||||
|
C00045114
|
Totarolenone
|
No. 760 |
|
|||||
|
C00021587
|
alpha-Acorenol
|
No. 1187 | No. 38 |
|
||||
|
C00021586
|
beta-Acorenol
|
No. 1187 | No. 38 |
|
||||
|
C00003063
|
gamma-Thujaplicin
|
CHEMBL1275999
|
No. 1304 | No. 35 |
|
|||
|
C00010876
|
Thymoquinone
/ p-Mentha-3,6-diene-2,5-dione |
CHEMBL1672002
|
C003466
|
2 / 15 | No. 7863 |
|
Human Protein / Gene in interactions
32 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002597 C00031283 C00040508 | 2 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002597 C00031283 C00040508 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00002597 C00031283 C00040508 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002597 C00031283 C00040508 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002597 C00031283 C00040508 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003112 C00040508 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002597 C00040508 | 0 / 1 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00003444 C00031283 | 0 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00003444 C00031283 | 1 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00031283 C00040508 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00031283 C00040508 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002597 C00040508 | 1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00040508 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003112 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00031283 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00031283 | 1 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00003444 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00031283 | 0 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00031283 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003112 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00031283 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003112 | 3 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003112 | 11 / 10 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00040508 | 4 / 3 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00040508 | 0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00040508 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00040508 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00040508 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00040508 | 7 / 37 |
| O00255 | Menin | Unclassified protein | C00040508 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00040508 | 1 / 2 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00040508 | 1 / 1 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00010876
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00010876
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (43)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (65)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000419 | Albuminuria |
C00010876
|
| D001169 | Arthritis, Experimental |
C00010876
|
| D001172 | Arthritis, Rheumatoid |
C00010876
|
| D002286 | Carcinoma, Ehrlich Tumor |
C00010876
|
| D003921 | Diabetes Mellitus, Experimental |
C00010876
|
| D003928 | Diabetic Nephropathies |
C00010876
|
| D056486 | Drug-Induced Liver Injury |
C00010876
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00010876
|
| D005198 | Fanconi Syndrome |
C00010876
|
| D006973 | Hypertension |
C00010876
|
| D007249 | Inflammation |
C00010876
|
| D008206 | Lymphatic Diseases |
C00010876
|
| D009374 | Neoplasms, Experimental |
C00010876
|
| D011507 | Proteinuria |
C00010876
|
| D011658 | Pulmonary Fibrosis |
C00010876
|