Cladosporium sp.
Species
KNApSAcK Entry
| Organism name | Cladosporium sp. |
|---|---|
| Genus | Cladosporium |
| Family | Davidiellaceae |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cladosporium |
|---|---|
| Linked NCBI taxonomy ID | 5498 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Davidiellaceae |
|---|---|
| ID | 452563 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (19)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00034046
|
Macrosporin
|
CHEMBL463054
|
C058810
|
23 / 26 / 26 | No. 41 | No. 62 |
|
|
|
C00003652
|
Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol |
CHEMBL222608
CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225 |
D004875
|
12 / 14 / 11 | No. 111 | No. 11 |
|
|
|
C00032839
|
Cladosporide A
|
No. 218 | No. 51 |
|
||||
|
C00003418
|
Cotylenin F
|
No. 563 | No. 41 |
|
||||
|
C00023897
|
Cephalosporin P1
|
No. 725 |
|
|||||
|
C00036496
|
2-Hydroxyjuglone
|
CHEMBL1089486
|
C420979
|
No. 1047 | No. 80 |
|
||
|
C00002791
|
Altersolanol A
|
CHEMBL512054
|
C058812
|
23 / 26 / 26 | No. 2024 |
|
||
|
C00030200
|
Ergosterol peroxide
/ Ergosterol 5,8-peroxide / (-)-Ergosterol 5,8-peroxide / 5alpha,8alpha-Epidioxyergosta-6,22-dien-3beta-ol / (-)-5alpha,8alpha-Epidioxyergosta-6,22-dien-3beta-ol |
CHEMBL434750
CHEMBL515808 CHEMBL1801968 CHEMBL1969254 |
C036071
|
1 / 0 / 0 | 1 / 4 | No. 2300 |
|
|
|
C00033632
|
Altersolanol J
|
CHEMBL449194
|
No. 3065 |
|
||||
|
C00045587
|
7-Hydroxy-1(3H)-isobenzofuranone
|
No. 3101 |
|
|||||
|
C00042630
|
iso-Cladospolide B
/ (-)-iso-Cladospolide B |
No. 3287 |
|
|||||
|
C00045552
|
3-(2-Formyl-3-hydroxyphenyl)-propionic acid
|
No. 3466 |
|
|||||
|
C00042824
|
Pandangolide 1a
/ (-)-Pandangolide 1a |
No. 4221 |
|
|||||
|
C00045588
|
7-Hydroxy-3-(2,3-dihydroxybutyl)-1(3H)-isobenzofuranone
|
CHEMBL504109
|
No. 4544 |
|
||||
|
C00045782
|
Cladoacetal B
/ (-)-Cladoacetal B |
CHEMBL507715
|
No. 5322 |
|
||||
|
C00045781
|
Cladoacetal A
/ (+)-Cladoacetal A |
CHEMBL507715
|
No. 5322 |
|
||||
|
C00045474
|
(+)-Cyclosordariolone
|
CHEMBL455579
|
No. 5728 |
|
||||
|
C00046049
|
Isoochracinic acid
|
CHEMBL451875
|
No. 7695 |
|
||||
|
C00045560
|
3-Deoxyisoochracinic acid
/ (-)-3-Deoxyisoochracinic acid |
CHEMBL461824
|
No. 8790 |
|
Human Protein / Gene in interactions
36 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00002791 C00034046 | 1 / 3 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00002791 C00034046 | 1 / 3 |
| O14965 | Aurora kinase A | Aur | C00002791 C00034046 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00002791 C00034046 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00002791 C00034046 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00002791 C00034046 | 4 / 1 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00002791 C00034046 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002791 C00034046 | 1 / 8 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00002791 C00034046 | 0 / 0 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00002791 C00034046 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00002791 C00034046 | 1 / 1 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00002791 C00034046 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00002791 C00034046 | 0 / 0 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00002791 C00034046 | 1 / 1 |
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00002791 C00034046 | 0 / 0 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00002791 C00034046 | 2 / 1 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00002791 C00034046 | 5 / 4 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002791 C00034046 | 5 / 9 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00002791 C00034046 | 2 / 3 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002791 C00034046 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00002791 C00034046 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00002791 C00034046 | 1 / 0 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00002791 C00034046 | 5 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00030200 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003652 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003652 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003652 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003652 | 2 / 3 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003652 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003652 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003652 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003652 | 0 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003652 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003652 | 4 / 3 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003652 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003652 | 1 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00030200
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (40)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #143500 | Gilbert syndrome |
P22309
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #114550 | Hepatocellular carcinoma |
P08581
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #211980 | Lung cancer |
P00533
P04626 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #176920 | Proteus syndrome |
P31749
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (37)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P08581 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00026 | Endometrial Cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P08581 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00015 | Malignant pleural mesothelioma |
P08069
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00021 | Renal cell carcinoma |
P08581
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|