Species

KNApSAcK Entry

Organism name Lindera umbellata
Genus Lindera
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lindera umbellata
Linked NCBI taxonomy ID 128640
Linked level species

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009291 External link 512 Cinnamtannin B1
CHEMBL540956
CHEMBL81478
CHEMBL445468
CHEMBL1213875
CHEMBL1213876
14 / 4 / 7 No. 29 No. 19
C00009289 External link 512 Cinnamtannin D1
CHEMBL540956
CHEMBL81478
CHEMBL445468
CHEMBL1213875
CHEMBL1213876
14 / 4 / 7 No. 29 No. 19
C00007929 External link 512 2',6'-Dihydroxy-4'-methoxydihydrochalcone
CHEMBL486009
No. 90 No. 13
C00007928 External link 512 2',4',6'-Trihydroxydihydrochalcone
/ 3-Phenyl-1-(2,4,6-trihydroxyphenyl)-1-propanone
CHEMBL503375
8 / 5 / 4 No. 90 No. 13
C00006934 External link 512 Pinostrobin chalcone
/ 2',6'-Dihydroxy-4'-methoxychalcone
CHEMBL317221
CHEMBL1705800
3 / 1 / 2 No. 92 No. 13
C00006935 External link 512 Cardamomin
CHEMBL378104
13 / 18 / 14 No. 92 No. 13
C00009308 External link 512 Cinnamtannin B2
CHEMBL410924
CHEMBL411351
CHEMBL502146
11 / 2 / 2 No. 113 No. 19
C00009307 External link 512 Cinnamtannin D2
CHEMBL410924
CHEMBL411351
CHEMBL502146
11 / 2 / 2 No. 113 No. 19
C00002987 External link 512 5,6-Dehydrokawain
CHEMBL254218
C052297
12 / 16 / 44 No. 1312 No. 63
C00008015 External link 512 (+)-Linderatin
CHEMBL458842
CHEMBL458843
No. 1753
C00007129 External link 512 Linderachalcone
No. 1753
C00008403 External link 512 Linderatone
No. 1753
C00007130 External link 512 2',6'-Dihydroxy-3'-(1-p-menthen-3-yl)-4'-methoxychalcone
No. 1753
C00008016 External link 512 Methyllinderatin
CHEMBL1169695
No. 1753
C00008404 External link 512 Neolinderatone
No. 2449
C00008017 External link 512 Neolinderatin
CHEMBL463218
CHEMBL459011
No. 2449
C00007135 External link 512 Neolinderachalcone
No. 2449
C00014449 External link 512 Linderol A
/ (-)-Linderol A
No. 5342

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O94806 Serine/threonine-protein kinase D3 Pkd C00009289 C00009291 C00009307 C00009308 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00009289 C00009291 C00009307 C00009308 0 / 0
P41743 Protein kinase C iota type Iota C00009289 C00009291 C00009307 C00009308 0 / 0
P24723 Protein kinase C eta type Eta C00009289 C00009291 C00009307 C00009308 1 / 0
P05771 Protein kinase C beta type Alpha C00009289 C00009291 C00009307 C00009308 0 / 0
P05129 Protein kinase C gamma type Alpha C00009289 C00009291 C00009307 C00009308 1 / 1
Q05655 Protein kinase C delta type Delta C00009289 C00009291 C00009307 C00009308 0 / 0
P17252 Protein kinase C alpha type Alpha C00009289 C00009291 C00009307 C00009308 0 / 0
Q05513 Protein kinase C zeta type Iota C00009289 C00009291 C00009307 C00009308 0 / 0
Q02156 Protein kinase C epsilon type Eta C00009289 C00009291 C00009307 C00009308 0 / 0
Q04759 Protein kinase C theta type Delta C00009289 C00009291 C00009307 C00009308 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00009289 C00009291 0 / 3
Q06187 Tyrosine-protein kinase BTK Tec C00009289 C00009291 2 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00006935 C00007928 4 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00006935 C00007928 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00006935 C00007928 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00009289 C00009291 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002987 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00006935 7 / 3
Q96RI1 Bile acid receptor NR1H4 C00002987 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002987 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002987 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00006934 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00006935 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00007928 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00006935 1 / 0
O75496 Geminin Unclassified protein C00006935 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00006934 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006935 2 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002987 0 / 0
P10275 Androgen receptor NR3C4 C00002987 3 / 4
P35869 Aryl hydrocarbon receptor Transcription Factor C00002987 0 / 0
O00255 Menin Unclassified protein C00006935 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006935 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00002987 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00006934 0 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002987 0 / 0
Q96LD8 Sentrin-specific protease 8 Enzyme C00007928 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002987 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00007928 1 / 1
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00006935 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002987 7 / 37
Q99700 Ataxin-2 Unclassified protein C00006935 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00006935 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002987 4 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00007928 0 / 0
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00007928 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#300755 Agammaglobulinemia, x-linked; xla Q06187
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (63)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)