| Organism name | Lindera umbellata |
|---|---|
| Genus | Lindera |
| Family | Lauraceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Lindera umbellata |
|---|---|
| Linked NCBI taxonomy ID | 128640 |
| Linked level | species |
| Family in NCBI taxonomy | Lauraceae |
|---|---|
| ID | 3433 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00009291
|
Cinnamtannin B1
|
CHEMBL540956
CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876 |
14 / 4 / 7 | No. 29 | No. 19 |
|
||
|
C00009289
|
Cinnamtannin D1
|
CHEMBL540956
CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876 |
14 / 4 / 7 | No. 29 | No. 19 |
|
||
|
C00007929
|
2',6'-Dihydroxy-4'-methoxydihydrochalcone
|
CHEMBL486009
|
No. 90 | No. 13 |
|
|||
|
C00007928
|
2',4',6'-Trihydroxydihydrochalcone
/ 3-Phenyl-1-(2,4,6-trihydroxyphenyl)-1-propanone |
CHEMBL503375
|
8 / 5 / 4 | No. 90 | No. 13 |
|
||
|
C00006934
|
Pinostrobin chalcone
/ 2',6'-Dihydroxy-4'-methoxychalcone |
CHEMBL317221
CHEMBL1705800 |
3 / 1 / 2 | No. 92 | No. 13 |
|
||
|
C00006935
|
Cardamomin
|
CHEMBL378104
|
13 / 18 / 14 | No. 92 | No. 13 |
|
||
|
C00009308
|
Cinnamtannin B2
|
CHEMBL410924
CHEMBL411351 CHEMBL502146 |
11 / 2 / 2 | No. 113 | No. 19 |
|
||
|
C00009307
|
Cinnamtannin D2
|
CHEMBL410924
CHEMBL411351 CHEMBL502146 |
11 / 2 / 2 | No. 113 | No. 19 |
|
||
|
C00002987
|
5,6-Dehydrokawain
|
CHEMBL254218
|
C052297
|
12 / 16 / 44 | No. 1312 | No. 63 |
|
|
|
C00008015
|
(+)-Linderatin
|
CHEMBL458842
CHEMBL458843 |
No. 1753 |
|
||||
|
C00007129
|
Linderachalcone
|
No. 1753 |
|
|||||
|
C00008403
|
Linderatone
|
No. 1753 |
|
|||||
|
C00007130
|
2',6'-Dihydroxy-3'-(1-p-menthen-3-yl)-4'-methoxychalcone
|
No. 1753 |
|
|||||
|
C00008016
|
Methyllinderatin
|
CHEMBL1169695
|
No. 1753 |
|
||||
|
C00008404
|
Neolinderatone
|
No. 2449 |
|
|||||
|
C00008017
|
Neolinderatin
|
CHEMBL463218
CHEMBL459011 |
No. 2449 |
|
||||
|
C00007135
|
Neolinderachalcone
|
No. 2449 |
|
|||||
|
C00014449
|
Linderol A
/ (-)-Linderol A |
No. 5342 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00009289 C00009291 C00009307 C00009308 | 1 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00009289 C00009291 C00009307 C00009308 | 1 / 1 |
| Q05655 | Protein kinase C delta type | Delta | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00009289 C00009291 C00009307 C00009308 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00009289 C00009291 C00009307 C00009308 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00009289 C00009291 | 0 / 3 |
| Q06187 | Tyrosine-protein kinase BTK | Tec | C00009289 C00009291 | 2 / 2 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00006935 C00007928 | 4 / 3 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00006935 C00007928 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00006935 C00007928 | 0 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00009289 C00009291 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002987 | 0 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00006935 | 7 / 3 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002987 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002987 | 2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00002987 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00006934 | 1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00006935 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00007928 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00006935 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00006935 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00006934 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00006935 | 2 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002987 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002987 | 3 / 4 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00002987 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00006935 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00006935 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002987 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00006934 | 0 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002987 | 0 / 0 |
| Q96LD8 | Sentrin-specific protease 8 | Enzyme | C00007928 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002987 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00007928 | 1 / 1 |
| P22001 | Potassium voltage-gated channel subfamily A member 3 | KCNA, Kv1.x (Shaker) | C00006935 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002987 | 7 / 37 |
| Q99700 | Ataxin-2 | Unclassified protein | C00006935 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00006935 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002987 | 4 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00007928 | 0 / 0 |
| Q9HCT0 | Fibroblast growth factor 22 | Unclassified protein | C00007928 | 0 / 0 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300755 | Agammaglobulinemia, x-linked; xla |
Q06187
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #307200 | Isolated growth hormone deficiency, type iii; ighd3 |
Q06187
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) |
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00085 | Agammaglobulinemias |
Q06187
(related)
|
| H00254 | Pituitary Dwarfism (PD) |
Q06187
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|