Entry
Name
Glycine, serine and threonine metabolism - Homo sapiens (human)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:
M00020 ], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:
M00018 ].
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
hsa00260 Glycine, serine and threonine metabolism
Ortholog table
Module
Network
Element
N01610 Dihydrolipoamide dehydrogenase
N01611 Glycine cleavage system
N01613 Glycine cleavage system, Gly to MTHF
N01791 Glycine metabolism, Ser to Gly
N01867 Demethylation of dimethylglycine
N01868 Demethylation of sarcosine
Drug
D00505 Phenelzine sulfate (USP)
D00826 Tranylcypromine sulfate (USP)
D01888 Safrazine hydrochloride (JAN)
D08393 Pirlindole hydrochloride
Other DBs
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
124908081 glycine cleavage system H protein, mitochondrial-like [KO:K02437 ]
2653 GCSH; glycine cleavage system protein H [KO:K02437 ]
Compound
C00143 5,10-Methylenetetrahydrofolate
C00441 L-Aspartate 4-semialdehyde
C01242 [Protein]-S8-aminomethyldihydrolipoyllysine
C03508 L-2-Amino-3-oxobutanoic acid
C06442 N(gamma)-Acetyldiaminobutyrate
C19929 N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Kuhlmann AU, Bremer E.
Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
Journal
Reference
Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
Journal
Reference
Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
Journal
Reference
Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
Journal
Reference
Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
Journal
Reference
Authors
Rees WD, Hay SM
Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
Journal
Reference
Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
Journal
Reference
Authors
Chen X, Jhee KH, Kruger WD
Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
Journal
Related pathway
hsa00250 Alanine, aspartate and glutamate metabolism
hsa00270 Cysteine and methionine metabolism
hsa00290 Valine, leucine and isoleucine biosynthesis
hsa00330 Arginine and proline metabolism
hsa00630 Glyoxylate and dicarboxylate metabolism
KO pathway