KEGG   PATHWAY: ko00380Help
Entry
ko00380                     Pathway                                

Name
Tryptophan metabolism
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
ko00380  Tryptophan metabolism
ko00380

Ortholog table
Module
M00037  Melatonin biosynthesis, tryptophan => serotonin => melatonin [PATH:ko00380]
M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:ko00380]
Disease
H00178  Glutaric acidemia
H00203  Acatalasemia
H00548  Brunner syndrome
H00689  Delayed sleep phase syndrome
H01161  Aromatic L-amino acid decarboxylase deficiency
H01203  Primary congenital glaucoma
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
H01583  Hydroxykynureninuria
H02087  Vertebral, cardiac, renal, and limb defects syndrome
Other DBs
BSID: 332
GO: 0006568 0009851
Orthology
K00453  tryptophan 2,3-dioxygenase [EC:1.13.11.11]
K00463  indoleamine 2,3-dioxygenase [EC:1.13.11.52]
K01432  arylformamidase [EC:3.5.1.9]
K14263  kynurenine formamidase [EC:3.5.1.9]
K07130  arylformamidase [EC:3.5.1.9]
K00486  kynurenine 3-monooxygenase [EC:1.14.13.9]
K01556  kynureninase [EC:3.7.1.3]
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9 1.14.14.8]
K16902  FAD reductase [NAD(P)H] [EC:1.5.1.45]
K00452  3-hydroxyanthranilate 3,4-dioxygenase [EC:1.13.11.6]
K03392  aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45]
K10217  aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.85 1.2.1.32]
K15067  2-aminomuconate deaminase [EC:3.5.99.5]
K00164  2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]
K00252  glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:5.3.3.8 5.1.2.3 4.2.1.17 1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:5.1.2.3 4.2.1.17 1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.211 4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:5.3.3.8 1.1.1.35 4.2.1.17]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00816  kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase [EC:2.6.1.64 4.4.1.13 2.6.1.7]
K00825  kynurenine/2-aminoadipate aminotransferase [EC:2.6.1.39 2.6.1.7]
K14264  kynurenine aminotransferase [EC:2.6.1.7]
K01667  tryptophanase [EC:4.1.99.1]
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.105 4.1.1.28]
K22433  L-tryptophan decarboxylase [EC:4.1.1.105]
K00274  monoamine oxidase [EC:1.4.3.4]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.3 1.2.1.8 1.2.1.31]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.3 1.2.1.47]
K00157  aldehyde oxidase [EC:1.2.3.1]
K00543  acetylserotonin O-methyltransferase [EC:2.1.1.4]
K00669  arylalkylamine N-acetyltransferase [EC:2.3.1.87]
K22450  aralkylamine N-acetyltransferase [EC:2.3.1.87]
K22588  acetylserotonin O-methyltransferase, plant [EC:2.1.1.4]
K00493  unspecific monooxygenase [EC:1.14.14.1]
K07408  cytochrome P450 family 1 subfamily A polypeptide 1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A polypeptide 2 [EC:1.14.14.1]
K07410  cytochrome P450 family 1 subfamily B polypeptide 1 [EC:1.14.14.1]
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.6.2.4 1.14.14.1]
K00562  methyltransferase [EC:2.1.1.96 2.1.1.49]
K11812  tryptophan N-monooxygenase [EC:1.14.14.156]
K11813  tryptophan N-monooxygenase [EC:1.14.14.156]
K11816  indole-3-pyruvate monooxygenase [EC:1.14.13.168]
K03334  L-amino-acid oxidase [EC:1.4.3.2]
K14265  tryptophan aminotransferase [EC:2.6.1.27]
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.5 2.6.1.27 2.6.1.39 2.6.1.57]
K16903  L-tryptophan---pyruvate aminotransferase [EC:2.6.1.99]
K00837  aromatic aminotransferase [EC:2.6.1.-]
K04103  indolepyruvate decarboxylase [EC:4.1.1.74]
K11182  diamine oxidase [EC:1.4.3.22]
K11868  indoleacetaldoxime dehydratase [EC:4.99.1.6]
K11817  indole-3-acetaldehyde oxidase [EC:1.2.3.7]
K22417  benzaldehyde dehydrogenase (NAD+) / indole-3-acetaldehyde oxidase [EC:1.2.3.7 1.2.1.28]
K01501  nitrilase [EC:3.5.5.1]
K01721  nitrile hydratase subunit alpha [EC:4.2.1.84]
K20807  nitrile hydratase subunit beta [EC:4.2.1.84]
K00466  tryptophan 2-monooxygenase [EC:1.13.12.3]
K01426  amidase [EC:3.5.1.4]
K21801  indoleacetamide hydrolase [EC:3.5.1.-]
K11818  aromatic aldoxime N-monooxygenase [EC:1.14.14.45]
K11819  S-alkyl-thiohydroximate lyase SUR1 [EC:4.4.1.-]
K11820  N-hydroxythioamide S-beta-glucosyltransferase [EC:2.4.1.195]
K11821  aromatic desulfoglucosinolate sulfotransferase [EC:2.8.2.24]
K01237  myrosinase [EC:3.2.1.147]
K03781  catalase [EC:1.11.1.6]
K03782  catalase-peroxidase [EC:1.11.1.21]
K20219  o-aminophenol oxidase [EC:1.10.3.4]
K20204  grixazone synthase / o-aminophenol oxidase [EC:1.10.3.4 1.10.3.15]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02043  Indolelactate
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
Reference
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083

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