KEGG   PATHWAY: pps04630
Entry
pps04630                    Pathway                                
Name
JAK-STAT signaling pathway - Pan paniscus (bonobo)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
pps04630  JAK-STAT signaling pathway
pps04630

Other DBs
GO: 0007259
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100967294  IL3; interleukin-3 [KO:K04736]
100967539  [KO:K05414]
100967748  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100967833  [KO:K07293] [EC:3.1.3.48]
100968231  [KO:K05414]
100968717  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100969081  PIAS3; E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
100969217  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
100969275  [KO:K05414]
100969444  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100969527  CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701]
100969624  [KO:K05414]
100969647  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X8 [KO:K18026] [EC:3.1.3.48]
100969808  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100969981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100970300  [KO:K05414]
100970355  IL21R; interleukin-21 receptor [KO:K05075]
100970556  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100970658  [KO:K05414]
100970737  LIFR; leukemia inhibitory factor receptor [KO:K05058]
100970831  PRL; prolactin isoform X1 [KO:K05439]
100971303  LIF; leukemia inhibitory factor [KO:K05419]
100971425  [KO:K05438]
100971620  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
100971653  OSM; oncostatin-M [KO:K05418]
100971675  IFNA6; interferon alpha-6 [KO:K05414]
100971967  TSLP; thymic stromal lymphopoietin isoform X2 [KO:K05436]
100972005  [KO:K05414]
100972031  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100972035  JAK3; tyrosine-protein kinase JAK3 isoform X2 [KO:K11218] [EC:2.7.10.2]
100972085  STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221]
100972202  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100972250  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
100972295  CTF1; cardiotrophin-1 [KO:K05422]
100972354  [KO:K05414]
100972442  [KO:K05438]
100972565  IL9; interleukin-9 [KO:K05432]
100972595  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
100972691  IFNA8; interferon alpha-8 [KO:K05414]
100972785  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
100972895  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100972902  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100972953  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100973020  [KO:K05438]
100973049  [KO:K05414]
100973587  IRF9; interferon regulatory factor 9 isoform X5 [KO:K04693]
100974265  IL23A; interleukin-23 subunit alpha [KO:K05426]
100974292  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100974295  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X4 [KO:K05059]
100974407  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
100974885  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100975260  LEPR; leptin receptor isoform X2 [KO:K05062]
100975561  IFNL3; interferon lambda-3 [KO:K22669]
100975632  EGF; pro-epidermal growth factor [KO:K04357]
100975853  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100976110  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
100976419  [KO:K05447]
100976754  [KO:K22669]
100976877  IL11RA; interleukin-11 receptor subunit alpha isoform X6 [KO:K05056]
100977044  IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137]
100977882  FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365]
100977916  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100978176  GFAP; glial fibrillary acidic protein isoform X2 [KO:K05640]
100978293  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
100978589  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100979090  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
100979574  IL12A; interleukin-12 subunit alpha [KO:K05406]
100979595  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100979712  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
100979742  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100979809  BCL2L1; bcl-2-like protein 1 isoform X2 [KO:K04570]
100979897  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
100980038  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100980204  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100980274  EPOR; erythropoietin receptor isoform X2 [KO:K05079]
100980367  GHR; growth hormone receptor isoform X2 [KO:K05080]
100980796  THPO; thrombopoietin isoform X1 [KO:K06854]
100980904  IL23R; interleukin-23 receptor [KO:K05065]
100981146  [KO:K05078]
100981232  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
100981507  EPO; erythropoietin [KO:K05437]
100982237  PRLR; prolactin receptor isoform X2 [KO:K05081]
100982287  IFNK; interferon kappa [KO:K05441]
100982337  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100982658  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
100982675  IL11; interleukin-11 isoform X3 [KO:K05417]
100983076  IL31; interleukin-31 [KO:K22631]
100983185  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
100983807  LEP; leptin [KO:K05424]
100983900  [KO:K05438]
100984257  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
100984436  IL21; interleukin-21 [KO:K05434]
100984583  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100984780  IL2; interleukin-2 [KO:K05429]
100984888  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100985296  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
100986080  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100986352  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
100986540  IL7; interleukin-7 isoform X1 [KO:K05431]
100986679  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100986810  [KO:K24382]
100987428  MPL; thrombopoietin receptor [KO:K05082]
100987766  STAT3; signal transducer and activator of transcription 3 isoform X7 [KO:K04692]
100988257  IL15; interleukin-15 isoform X1 [KO:K05433]
100988550  [KO:K11223]
100988608  CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738]
100988791  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
100988832  IL24; interleukin-24 isoform X1 [KO:K22668]
100988878  IL4; interleukin-4 isoform X1 [KO:K05430]
100988947  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
100989105  [KO:K11224]
100989242  SOCS2; suppressor of cytokine signaling 2 isoform X2 [KO:K04695]
100989661  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
100989690  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
100989732  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100989787  IL13; interleukin-13 isoform X1 [KO:K05435]
100989863  IL20; interleukin-20 [KO:K22667]
100989950  IL12B; interleukin-12 subunit beta [KO:K05425]
100990004  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
100990108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100990188  IL19; interleukin-19 isoform X1 [KO:K05444]
100990286  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
100990760  IL10; interleukin-10 isoform X1 [KO:K05443]
100990828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100990850  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100990906  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
100991249  IL5; interleukin-5 [KO:K05428]
100991389  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100991722  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
100991779  IFNG; interferon gamma [KO:K04687]
100991804  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100991889  [KO:K05073]
100992032  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100992126  IL26; interleukin-26 [KO:K05446]
100992438  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100992951  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100993386  HRAS; GTPase HRas isoform X1 [KO:K02833]
100993433  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
100993451  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100993667  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
100993771  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X2 [KO:K05139]
100994315  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100994342  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
100994582  IL27; interleukin-27 subunit alpha [KO:K22629]
100994584  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
100994639  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:2.3.2.27]
100995155  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
100995446  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100995605  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
100995621  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
100995645  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
100995734  [KO:K05414]
100995792  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100995827  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
100995851  IFNB1; interferon beta [KO:K05415]
100995954  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100996136  IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135]
100996206  [KO:K05440]
103782925  CNTF; ciliary neurotrophic factor [KO:K05420]
103786410  MYC; myc proto-oncogene protein [KO:K04377]
112440856  IFNE; interferon epsilon [KO:K05442]
117976196  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
117976712  [KO:K05438]
117981650  [KO:K05414]
117981652  [KO:K05414]
129392943  [KO:K05438]
129393500  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
129395249  [KO:K05066]
129395308  IL9R; interleukin-9 receptor isoform X2 [KO:K05073]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
pps04010  MAPK signaling pathway
pps04060  Cytokine-cytokine receptor interaction
pps04110  Cell cycle
pps04120  Ubiquitin mediated proteolysis
pps04151  PI3K-Akt signaling pathway
pps04210  Apoptosis
KO pathway
ko04630   

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