KEGG   PATHWAY: pps04630
pps04630                    Pathway                                

JAK-STAT signaling pathway - Pan paniscus (bonobo)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
pps04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Pan paniscus (bonobo) [GN:pps]
100984780  IL2; interleukin 2 [KO:K05429]
100967294  IL3; interleukin 3 [KO:K04736]
100988878  IL4; interleukin 4 [KO:K05430]
100991249  IL5; interleukin 5 [KO:K05428]
100967827  IL6; interleukin 6 [KO:K05405]
100986540  IL7; interleukin 7 [KO:K05431]
100972565  IL9; interleukin 9 [KO:K05432]
100990760  IL10; interleukin 10 [KO:K05443]
100982675  IL11; interleukin 11 [KO:K05417]
100979574  IL12A; interleukin 12A [KO:K05406]
100989950  IL12B; interleukin 12B [KO:K05425]
100989787  IL13; interleukin 13 [KO:K05435]
100988257  IL15; interleukin 15 [KO:K05433]
100974554  IL17D; interleukin 17D [KO:K05492]
100990188  IL19; interleukin 19 [KO:K05444]
100989863  IL20; interleukin 20 [KO:K22667]
100984436  IL21; interleukin 21 [KO:K05434]
100992466  IL22; interleukin 22 [KO:K05445]
100974265  IL23A; interleukin 23 subunit alpha [KO:K05426]
100988832  IL24; interleukin 24 [KO:K22668]
100970300  interferon alpha-17-like [KO:K05414]
100967539  interferon alpha-21 [KO:K05414]
100968231  interferon alpha-17 [KO:K05414]
100968579  interferon alpha-7 [KO:K05414]
100969624  interferon alpha-16 [KO:K05414]
100970658  IFNA14; interferon alpha-14 [KO:K05414]
100971675  IFNA6; interferon alpha 6 [KO:K05414]
100972354  IFNA2; interferon alpha 2 [KO:K05414]
100972691  IFNA8; interferon alpha 8 [KO:K05414]
100973049  interferon alpha-1/13 [KO:K05414]
100995734  IFNA5; interferon alpha-5 [KO:K05414]
100969275  interferon alpha-10-like [KO:K05414]
100972005  interferon alpha-1/13-like [KO:K05414]
100968923  interferon alpha-17-like [KO:K05414]
100995851  IFNB1; interferon beta 1 [KO:K05415]
100991779  IFNG; interferon gamma [KO:K04687]
100973400  IFNE; interferon epsilon [KO:K05442]
100982287  IFNK; interferon kappa [KO:K05441]
100976419  IFNL1; interferon lambda 1 [KO:K05447]
100976754  IL28A; interferon lambda-3 [KO:K22669]
100975561  interferon lambda-3-like [KO:K22669]
100996206  IFNW1; interferon omega 1 [KO:K05440]
100971653  OSM; oncostatin M [KO:K05418]
100971303  LIF; leukemia inhibitory factor [KO:K05419]
100971967  TSLP; thymic stromal lymphopoietin [KO:K05436]
100972295  CTF1; cardiotrophin 1 [KO:K05422]
100986810  cardiotrophin-2 [KO:K24382]
100995954  CSF2; colony stimulating factor 2 [KO:K05427]
103782925  CNTF; ciliary neurotrophic factor [KO:K05420]
100972250  CSF3; colony stimulating factor 3 [KO:K05423]
100981507  EPO; erythropoietin [KO:K05437]
100983900  uncharacterized LOC100983900 [KO:K05438]
100971425  GH1; growth hormone 1 [KO:K05438]
100985912  chorionic somatomammotropin hormone 2-like [KO:K05438]
100972442  GH2; growth hormone variant [KO:K05438]
100973020  chorionic somatomammotropin hormone 2 [KO:K05438]
100983807  LEP; leptin [KO:K05424]
100980796  THPO; thrombopoietin [KO:K06854]
100970831  PRL; prolactin [KO:K05439]
100975632  EGF; epidermal growth factor [KO:K04357]
100991389  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100984583  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100974407  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
100992438  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
100986679  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
100967540  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
100969808  IL4R; interleukin 4 receptor [KO:K05071]
100988791  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
100972031  IL6R; interleukin 6 receptor [KO:K05055]
100981232  IL7R; interleukin 7 receptor [KO:K05072]
100991889  IL9R; interleukin 9 receptor [KO:K05073]
100982658  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
100996136  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
100976877  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
100979712  IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063]
100984257  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
100967748  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
100986352  IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
100994584  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
100993433  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
100977044  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
100970355  IL21R; interleukin 21 receptor [KO:K05075]
100989661  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
100993771  IL22RA2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
100980904  IL23R; interleukin 23 receptor [KO:K05065]
100995621  IL27RA; interleukin 27 receptor subunit alpha [KO:K19598]
100992032  IL6ST; interleukin 6 signal transducer [KO:K05060]
100995446  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
100995792  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
100994342  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100988947  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100990004  IFNLR1; interferon lambda receptor 1 [KO:K05140]
100972785  OSMR; oncostatin M receptor [KO:K05057]
100970737  LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
100981146  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
100974295  CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
100980819  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
100988608  CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
100974292  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
100980274  EPOR; erythropoietin receptor [KO:K05079]
100980367  GHR; growth hormone receptor [KO:K05080]
100975260  LEPR; leptin receptor [KO:K05062]
100987428  MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
100982237  PRLR; prolactin receptor [KO:K05081]
100974885  EGFR; epidermal growth factor receptor [KO:K04361] [EC:]
100982337  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:]
100975853  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:]
100972202  JAK1; Janus kinase 1 [KO:K11217] [EC:]
100979742  JAK2; Janus kinase 2 [KO:K04447] [EC:]
100972035  JAK3; Janus kinase 3 [KO:K11218] [EC:]
100979090  TYK2; tyrosine kinase 2 [KO:K11219] [EC:]
100971620  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100972085  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100987766  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100972895  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100988550  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
100989105  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100989067  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100969527  CISH; cytokine inducible SH2 containing protein [KO:K04701]
100989242  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
100978589  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100989690  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
100978293  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
100979897  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
100993667  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
100992951  BCL2; BCL2, apoptosis regulator [KO:K02161]
100979595  MCL1; BCL2 family apoptosis regulator [KO:K02539]
100979809  BCL2L1; BCL2 like 1 [KO:K04570]
100995645  PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:]
103786410  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100995605  CCND1; cyclin D1 [KO:K04503]
100990850  CCND2; cyclin D2 [KO:K10151]
100972595  CCND3; cyclin D3 [KO:K10152]
100977916  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100968717  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:]
100978176  GFAP; glial fibrillary acidic protein [KO:K05640]
100976110  STAM2; signal transducing adaptor molecule 2 [KO:K04705]
100991722  STAM; signal transducing adaptor molecule [KO:K04705]
100969647  PTPN2; protein tyrosine phosphatase, non-receptor type 2 [KO:K18026] [EC:]
100990286  PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:]
100973587  IRF9; interferon regulatory factor 9 [KO:K04693]
100984888  CREBBP; CREB binding protein [KO:K04498] [EC:]
100983185  EP300; E1A binding protein p300 [KO:K04498] [EC:]
100995827  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
100995155  PIAS2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-]
100969081  PIAS3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-]
100994639  PIAS4; protein inhibitor of activated STAT 4 [KO:K16065] [EC:]
100977882  FHL1; four and a half LIM domains 1 [KO:K14365]
100970556  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:]
100993451  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100972953  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100980038  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100993386  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100972902  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
100989732  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
100990108  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
100990828  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
100986080  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100994315  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100969981  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100969217  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
100969444  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
100991804  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
100980204  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
pps04010  MAPK signaling pathway
pps04060  Cytokine-cytokine receptor interaction
pps04110  Cell cycle
pps04120  Ubiquitin mediated proteolysis
pps04151  PI3K-Akt signaling pathway
pps04210  Apoptosis
KO pathway

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