Entry Name JAK-STAT signaling pathway - Pan paniscus (bonobo)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Pan paniscus (bonobo) [GN:
pps ]
Gene 100967748 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
100969527 CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701 ]
100969808 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
100969981 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100971620 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220 ]
100972031 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
100972085 STAT2; signal transducer and activator of transcription 2 isoform X3 [KO:K11221 ]
100972250 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
100972785 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
100972895 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
100974292 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
100974295 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X4 [KO:K05059 ]
100976110 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
100976877 IL11RA; interleukin-11 receptor subunit alpha isoform X6 [KO:K05056 ]
100977044 IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137 ]
100977882 FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365 ]
100979595 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
100979712 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
100980038 SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099 ]
100981232 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
100982658 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
100984583 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
100985296 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
100986080 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100987766 STAT3; signal transducer and activator of transcription 3 isoform X7 [KO:K04692 ]
100988608 CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738 ]
100989732 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100990108 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100990828 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100990906 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
100991389 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
100991722 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
100992032 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
100993433 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
100993771 IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X2 [KO:K05139 ]
100994315 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
100994584 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
100995155 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
100995621 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
100995827 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
100995954 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
100996136 IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135 ]
129393500 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related pps04060 Cytokine-cytokine receptor interaction
KO pathway
