Haplophyllum spp.

• Index
• Plant Species
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Haplophyllum spp.
Genus	Haplophyllum
Family	Rutaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Haplophyllum
Linked NCBI taxonomy ID	266078
Linked level	genus

Family

Family in NCBI taxonomy	Rutaceae
ID	23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005548	Narcissin / Isorhamnetin 3-O-rutinoside	CHEMBL84174 CHEMBL258394 CHEMBL1711509 CHEMBL2165403	C031062	7 / 1 / 2		No. 1	No. 15
C00000640	(+)-Eudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879	C105875	2 / 0 / 0		No. 38	No. 21
C00002177	Kokusaginine	CHEMBL278779		9 / 7 / 3		No. 368	No. 7
C00002159	gamma-Fagarine / 4,8-Dimethoxyfuro[2,3-b]quinoline	CHEMBL252925	C049193	8 / 14 / 7		No. 368	No. 7
C00002151	Dictamine / Dictamnine	CHEMBL22533	C026398			No. 368	No. 7
C00002198	Skimmianine	CHEMBL21396	C035932	18 / 32 / 62		No. 368	No. 7
C00002488	Osthol / Osthole	CHEMBL52229	C046627	12 / 6 / 5	7 / 4	No. 466	No. 25
C00002158	Evoxine / 7-(2,3-Dihydroxy-3-methyl-butyl)oxy-8-methyldictamnine	CHEMBL1317300 CHEMBL1395597 CHEMBL1416006		14 / 9 / 9		No. 600	No. 7

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P00352	Retinal dehydrogenase 1	Enzyme	C00002158 C00002159 C00002198 C00002488	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002158 C00002159 C00002177 C00002198	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002158 C00002198 C00002488 C00005548	0 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002158 C00002159 C00002198 C00005548	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000640 C00002158 C00002198	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002158 C00002159 C00002198	2 / 2
O75496	Geminin	Unclassified protein	C00002198 C00002488 C00005548	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002177 C00002488 C00005548	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002158 C00002198	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002177 C00002488	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002158 C00002198	3 / 3
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002158 C00002198	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002158 C00002198	1 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002159 C00002198	1 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002158 C00002198	1 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002159	7 / 3
P07237	Protein disulfide-isomerase	Enzyme	C00005548	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002177	2 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002198	3 / 2
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002159	4 / 2
P37840	Alpha-synuclein	Unclassified protein	C00002177	4 / 2
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002488	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002198	11 / 10
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002488	0 / 0
P56817	Beta-secretase 1	A1A	C00002488	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002158	0 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00002488	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002158	1 / 1
P04062	Glucosylceramidase	Enzyme	C00002488	6 / 4
P03372	Estrogen receptor	NR3A1	C00005548	1 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002488	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002177	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00005548	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002177	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002177	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000640	0 / 0
O14980	Exportin-1	Unclassified protein	C00002488	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002198	7 / 37
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002159	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002158	1 / 0
O00255	Menin	Unclassified protein	C00002198	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002198	1 / 2
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002177	1 / 1

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
2180	ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2	acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)	C00002488
1374	CPT1A, CPT1, CPT1-L, L-CPT1	carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21)	C00002488
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002488
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002488
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002488
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00002488
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002488

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions