Helichrysum forskahlii

• Index
• Plant Species
• Metabolite list (20)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Helichrysum forskahlii
Genus	Helichrysum
Family	Asteraceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Helichrysum forskahlii
Linked NCBI taxonomy ID	630302
Linked level	species

Family

Family in NCBI taxonomy	Asteraceae
ID	4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (20)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00004632	Quercetin 3-methyl ether / Quercetin 3-O-methyl ether	CHEMBL163316		32 / 21 / 21		No. 3	No. 15
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00003738	beta-Amyrin / beta-Amirin / beta-Amyrine / beta-Amyrenol		C036380		0 / 4	No. 23	No. 51
C00000992	Pinocembrin	CHEMBL70518 CHEMBL399910 CHEMBL399249	C016063	18 / 23 / 23	5 / 0	No. 25	No. 14
C00008143	Alpinetin / (-)-Alpinetin	CHEMBL427218 CHEMBL254825				No. 25	No. 14
C00000965	Glabranin	CHEMBL253998 CHEMBL488888		5 / 2 / 3		No. 28	No. 14
C00033902	Helichrysone C / (+)-Helichrysone C					No. 28	No. 14
C00008189	7-O-Prenylpinocembrin					No. 28	No. 14
C00008171	Isoglabranin / 6-Prenylpinocembrin / 5,7-Dihydroxy-6-C-prenylflavanone	CHEMBL2143430 CHEMBL2165236		1 / 0 / 0		No. 28	No. 14
C00033901	Helichrysone B					No. 90	No. 13
C00006935	Cardamomin	CHEMBL378104		13 / 18 / 14		No. 92	No. 13
C00006933	2',4',6'-Trihydroxychalcone	CHEMBL129371		2 / 0 / 3		No. 92	No. 13
C00007086	2',6'-Dihydroxy-4'-prenyloxychalcone					No. 133	No. 13
C00007087	2'-Hydroxy-6'-methoxy-4'-prenyloxychalcone					No. 133	No. 13
C00033900	Helichrysone A					No. 133	No. 13
C00033565	Acetyloleanolic acid / Oleanolic acid acetate / 3-O-Acetyloleanolic acid / (+)-Acetyloleanolic acid / (+)-Oleanolic acid acetate / (+)-3-O-Acetyloleanolic acid / 3beta-Acetoxyolean-12-en-28-oic acid	CHEMBL486822 CHEMBL494653 CHEMBL1315416	C052658	1 / 0 / 0		No. 177
C00033563	3'',3''-Dimethyl-5',6'-pyrano-2',4'-dihydroxychalcone					No. 337
C00033772	Desmethylhelichromanochalcone					No. 337
C00007983	3',4',6'-Trihydroxy-2'-oxo-3',5'-diprenyldihydrochalcone					No. 2813
C00007984	Helihumulone					No. 2813

Human Protein / Gene in interactions

70 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000992 C00004632 C00006935	1 / 2
O75496	Geminin	Unclassified protein	C00004632 C00006935 C00019064	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000992 C00004632 C00019064	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00004632 C00006935 C00019064	0 / 0
O00255	Menin	Unclassified protein	C00000992 C00004632 C00006935	2 / 5
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000992 C00004632 C00019064	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000992 C00004632 C00006935	4 / 3
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000965 C00000992	1 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00006933 C00019064	0 / 3
O75164	Lysine-specific demethylase 4A	Enzyme	C00004632 C00006935	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00004632 C00006935	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000965 C00000992	0 / 1
P06746	DNA polymerase beta	Enzyme	C00004632 C00019064	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00019064 C00033565	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00004632 C00006935	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000992 C00004632	3 / 3
P11309	Serine/threonine-protein kinase pim-1	Pim	C00000965 C00000992	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00004632 C00006935	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00006933 C00019064	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000992 C00006935	7 / 3
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000965 C00000992	0 / 1
P15121	Aldose reductase	Enzyme	C00004632 C00019064	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000965 C00000992	1 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00004632 C00006935	2 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000992 C00019064	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00004632	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00019064	0 / 0
P42858	Huntingtin	Unclassified protein	C00004632	1 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00004632	1 / 0
P54132	Bloom syndrome protein	Enzyme	C00004632	1 / 2
P04792	Heat shock protein beta-1	Unclassified protein	C00004632	2 / 1
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019064	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00008171	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00004632	1 / 1
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00000992	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00004632	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00019064	2 / 2
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00000992	4 / 4
Q96RI1	Bile acid receptor	NR1H4	C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000992	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00004632	0 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00000992	0 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00019064	0 / 0
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00019064	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000992	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00006935	1 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00004632	1 / 1
P22001	Potassium voltage-gated channel subfamily A member 3	KCNA, Kv1.x (Shaker)	C00006935	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00004632	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00019064	0 / 1
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00019064	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00004632	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00004632	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00004632	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00004632	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00019064	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00019064	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00019064	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00019064	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00004632	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00004632	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00004632	2 / 1

24 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000992 C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000992 C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
6818	SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1)	C00000992
7052	TGM2, G-ALPHA-h, GNAH, TG2, TGC	transglutaminase 2 (EC:2.3.2.13)	C00000992
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00019064
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00019064
847	CAT	catalase (EC:1.11.1.6)	C00019064
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00000992
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00019064

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions