Croton lechleri Mull.Arg.
Species
KNApSAcK Entry
| Organism name | Croton lechleri Mull.Arg. |
|---|---|
| Genus | Croton |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Croton |
|---|---|
| Linked NCBI taxonomy ID | 100370 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (27)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001869
|
Isoboldine
/ (S)-Isoboldine |
CHEMBL462880
|
19 / 22 / 55 | No. 20 | No. 4 |
|
||
|
C00035705
|
Norisoboldine
|
CHEMBL375902
|
No. 20 | No. 4 |
|
|||
|
C00000956
|
(-)-Epicatechin
|
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
85 / 58 / 54 | No. 52 | No. 14 |
|
||
|
C00035626
|
Gallocatechin
|
CHEMBL47386
CHEMBL125743 CHEMBL130415 CHEMBL264167 CHEMBL404845 |
26 / 17 / 29 | No. 52 | No. 14 |
|
||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00029821
|
Sitostenone
/ beta-Sitostenone / Stigmast-4-en-3-one / Stigmast-4-ene-3-one |
CHEMBL66926
|
No. 53 | No. 11 |
|
|||
|
C00035671
|
Korberin A
|
No. 185 |
|
|||||
|
C00035505
|
4-O-Methylcedrusin
|
CHEMBL457819
|
No. 215 | No. 23 |
|
|||
|
C00035542
|
Bincatriol
/ (+)-Bincatriol |
No. 221 |
|
|||||
|
C00001885
|
Escholin
/ Escholine / Thalictrin / Thalictrine / Magnoflorine / (+)-Magnoflorine |
CHEMBL235428
|
C001670
|
No. 286 | No. 4 |
|
||
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00035672
|
Korberin B
|
No. 731 |
|
|||||
|
C00035473
|
2,4,6-Trimethoxyphenol
|
CHEMBL225314
|
No. 856 |
|
||||
|
C00035489
|
3,4-Dimethoxyphenol
|
No. 856 |
|
|||||
|
C00035568
|
Crolechinic acid
|
No. 982 |
|
|||||
|
C00035638
|
Hardwickiic acid
|
CHEMBL319344
CHEMBL461615 |
No. 982 |
|
||||
|
C00035487
|
3,4-Dimethoxybenzyl alcohol
|
C042197
|
No. 1412 |
|
||||
|
C00035729
|
Propyl acetate
|
CHEMBL44857
|
C026498
|
No. 4274 |
|
|||
|
C00001308
|
Ethyl acetate
|
CHEMBL14152
|
C007650
|
4 / 14 / 13 | 4 / 0 | No. 4274 |
|
|
|
C00035569
|
Crolechinol
|
No. 4326 |
|
|||||
|
C00035116
|
Isoamyl acetate
/ 3-Methylbutyl acetate |
CHEMBL42013
|
C020377
|
1 / 0 / 0 | No. 4683 |
|
||
|
C00035483
|
2-Methylbutyl acetate
|
No. 4683 |
|
|||||
|
C00035493
|
3-Methyl-2-pentanol
|
No. 5183 |
|
|||||
|
C00000136
|
1,8-Cineole
|
CHEMBL485259
CHEMBL1397305 |
99 / 57 / 50 | No. 5413 | No. 35 |
|
||
|
C00035454
|
1,3,5-Trimethoxybenzene
|
CHEMBL1605492
|
C015560
|
2 / 0 / 0 | No. 7496 |
|
||
|
C00035757
|
Taspine
|
CHEMBL470867
|
C018394
|
1 / 1 / 0 | No. 7718 |
|
||
|
C00035617
|
Ethyl propionate
|
CHEMBL44115
|
C069373
|
No. 7748 |
|
Human Protein / Gene in interactions
179 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000956 C00001308 C00001869 C00035454 C00035626 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000136 C00000956 C00001869 C00035626 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000956 C00001308 C00001869 C00035626 | 3 / 3 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000136 C00000956 C00001869 C00003672 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000136 C00000956 C00001869 C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000136 C00000956 C00001869 C00003672 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000136 C00000956 C00001869 C00035626 | 4 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000136 C00000956 C00001869 C00003672 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000956 C00001869 C00035626 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000136 C00000956 C00035626 | 0 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000956 C00001869 C00035626 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000136 C00000956 C00035626 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000956 C00003672 C00035626 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000956 C00001869 C00035626 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000136 C00000956 C00035626 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000956 C00003672 C00019308 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000136 C00035116 C00035454 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000136 C00000956 C00035626 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000136 C00000956 C00035626 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00000956 C00003672 C00019308 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000136 C00000956 C00003672 | 3 / 2 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000956 C00001869 C00035626 | 2 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000956 C00003672 C00019308 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000136 C00000956 C00003672 | 0 / 0 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00000956 C00035626 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001869 C00035626 | 0 / 1 |
| P17252 | Protein kinase C alpha type | Alpha | C00000136 C00000956 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000136 C00001869 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000136 C00001308 | 11 / 10 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00019308 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000136 C00003672 | 1 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000956 C00035626 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000136 C00000956 | 1 / 2 |
| P56817 | Beta-secretase 1 | A1A | C00000956 C00035626 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000136 C00000956 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000956 C00035626 | 2 / 3 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000136 C00035757 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000956 C00035626 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00019308 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000956 C00035626 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000956 C00001869 | 1 / 2 |
| P02768 | Serum albumin | Secreted protein | C00000956 C00035626 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001869 C00035626 | 1 / 4 |
| O00255 | Menin | Unclassified protein | C00000956 C00001869 | 2 / 5 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00000956 C00035626 | 0 / 7 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000956 C00035626 | 2 / 3 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00000956 C00035626 | 1 / 1 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000136 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00000956 | 1 / 2 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000136 | 1 / 8 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000956 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000136 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000136 | 2 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000136 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000136 | 0 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00000956 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000136 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000136 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000956 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000136 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000956 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000136 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000136 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000136 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000956 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000956 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000136 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000956 | 0 / 0 |
| P07998 | Ribonuclease pancreatic | Enzyme | C00000956 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000956 | 2 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000136 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000136 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000136 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000136 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000136 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000136 | 1 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000136 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000136 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000136 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000136 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000136 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000136 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000956 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000136 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000136 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000136 | 0 / 0 |
| P07711 | Cathepsin L1 | C1A | C00000956 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000136 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001308 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000136 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000136 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000956 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000956 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000956 | 3 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000136 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000136 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000136 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000136 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000136 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000136 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000136 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000136 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000136 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000136 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000136 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000136 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000136 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000136 | 0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000956 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00000136 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000136 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000136 | 1 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000136 | 1 / 1 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000956 | 0 / 1 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000136 | 2 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000136 | 0 / 1 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000956 | 0 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000956 | 0 / 1 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00000136 | 0 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00000956 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000136 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000956 | 5 / 2 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000136 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000136 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000956 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000136 | 1 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000956 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000136 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000136 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000956 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000136 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000136 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000136 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000136 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000956 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000956 | 1 / 1 |
| P55210 | Caspase-7 | C14 | C00001869 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000136 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000136 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000136 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000956 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000956 | 1 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000956 | 3 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000956 | 5 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000136 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000136 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000136 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000136 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000136 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000136 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000136 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000956 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000136 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000136 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000956 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P08246 | Neutrophil elastase | S1A | C00000136 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000136 | 2 / 2 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000136 | 0 / 0 |
| Q7Z2W7 | Transient receptor potential cation channel subfamily M member 8 | Unclassified protein | C00000136 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000956 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000956 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000956 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001869 | 7 / 37 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000956 | 3 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00000956 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00000956 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00000956 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000956 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00000956 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00000956 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00000956 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00000956 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00000956 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000956 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000956 | 0 / 0 |
4 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00001308
|
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) |
C00001308
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00001308
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001308
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (120)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (108)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) P08581 (related) P10415 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) P10415 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P10415 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P08581 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) P28907 (marker) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|