Species

KNApSAcK Entry

Organism name Erythrina lysistemon
Genus Erythrina
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Erythrina lysistemon
Linked NCBI taxonomy ID 347910
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (22)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00019057 External link 512 Isoerysenegalensein E
/ 5,7,4'-Trihydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-8-prenylisoflavone
CHEMBL559714
No. 14 No. 15
C00018966 External link 512 Eryvarin D
CHEMBL1097045
No. 15 No. 15
C00002586 External link 512 Wighteone
/ Erythrinin B
/ 5,7,4'-Trihydroxy-6-prenylisoflavone
CHEMBL393222
2 / 1 / 1 No. 15 No. 15
C00014200 External link 512 Burttinone
/ 5,7-Dihydroxy-4'-methoxy-3'-prenyl-5'-[(3-methyl-2-butenyl)phenyl]flavanone
CHEMBL515837
CHEMBL1977731
1 / 0 / 0 No. 19 No. 14
C00014175 External link 512 Abyssinone V 4'-methyl ether
/ 5,7-Dihydroxy-4'-methoxy-3',5'-diprenylflavanone
CHEMBL470249
CHEMBL1425525
20 / 20 / 13 No. 19 No. 14
C00009492 External link 512 Alpinumisoflavone
CHEMBL238628
C000154
3 / 1 / 1 1 / 0 No. 24 No. 15
C00019058 External link 512 Vogelin A
/ 5,7,2'-Trihydroxy-4'-methoxy-5'-prenylisoflavone
No. 28 No. 14
C00019059 External link 512 Isosenegalensin
/ 5,4'-Dihydroxy-5''-(1-hydroxy-1-methylethyl)-6-prenyl-4'',5''-dihydrofurano[2'',3'':7,8]isoflavone
CHEMBL565072
No. 47 No. 15
C00010002 External link 512 Isoneorautenol
/ 3-Hydroxy-6'',6''-dimethylpyrano[2'',3'':9,8]pterocarpan
CHEMBL1098729
No. 135 No. 15
C00009642 External link 512 Calopocarpin
/ 3,9-Dihydroxy-2-prenylpterocarpan
CHEMBL1096407
No. 188 No. 15
C00019461 External link 512 Erystagallin C
No. 188 No. 15
C00019070 External link 512 Erysubin D
/ (6aR,11aR)-3,5'-Dihydroxy-2-prenyl-6',6'-dimethyl-4',5'-dihydropyrano[2',3':9,10]-pterocarpan
CHEMBL1095422
No. 188 No. 15
C00002515 External link 512 Cristacarpin
/ Erythrabyssin I
CHEMBL454849
C085157
2 / 1 / 1 No. 325 No. 15
C00018967 External link 512 Orientanol C
No. 352 No. 15
C00001851 External link 512 Erysotrine
CHEMBL442947
No. 446 No. 4
C00027356 External link 512 Erythrartine
/ (+)-Erythrartine
/ 11-Hydroxyerysotrine
CHEMBL217996
No. 446 No. 4
C00019515 External link 512 Erysodin
/ Erysodine
CHEMBL446533
C097135
No. 446 No. 4
C00027353 External link 512 Erysotrine
/ (+)-Erysotrine
CHEMBL442947
No. 446 No. 4
C00027358 External link 512 Erythristemine
No. 446 No. 4
C00010016 External link 512 Erybraedin A
/ 4-Prenylphaseollidin
/ (6aR,11aR)-3,9-Dihydroxy-4,10-diprenylpterocarpan
CHEMBL564141
CHEMBL1984704
No. 460
C00028308 External link 512 Glucoerysodine
CHEMBL464248
No. 4244
C00028900 External link 512 Rhamnoerysodine
No. 4244

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00009492 C00014175 C00014200 0 / 0
P03372 Estrogen receptor NR3A1 C00002515 C00002586 C00009492 1 / 1
Q92731 Estrogen receptor beta NR3A2 C00002515 C00002586 C00009492 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00014175 7 / 3
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00014175 1 / 4
P39748 Flap endonuclease 1 Enzyme C00014175 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00014175 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00014175 2 / 0
O75496 Geminin Unclassified protein C00014175 0 / 0
Q99700 Ataxin-2 Unclassified protein C00014175 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00014175 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00014175 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00014175 1 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00014175 0 / 0
P17861 X-box-binding protein 1 Unclassified protein C00014175 1 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00014175 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00014175 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00014175 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00014175 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00014175 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00014175 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00014175 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00009492

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (14)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)