Species

KNApSAcK Entry

Organism name Glycyrrhiza aspera
Genus Glycyrrhiza
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Glycyrrhiza aspera
Linked NCBI taxonomy ID 74709
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (25)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004569 External link 512 Jaranol
/ Kumatakenin
/ Kumatakillin
/ Kaempferol 3,7-O-dimethyl ether
/ 5,4'-Dihydroxy-3,7-dimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL349724
No. 3 No. 15
C00014495 External link 512 Isoliquiritigenin 4'-O-glucoside 4-O-apiofuranosyl-(1'''->2''')-glucoside
/ 4,2',4'-Trihydroxychalcone 4'-O-glucoside 4-O-apiofuranosyl-(1'''->2''')-glucoside
No. 5 No. 15
C00005020 External link 512 Glyasperin A
/ 3,5,7-Trihydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
No. 14 No. 15
C00002542 External link 512 Licoisoflavone A
No. 15 No. 15
C00005010 External link 512 Isolicoflavonol
/ 3,5,7-Trihydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]-4H-1-benzopyran-4-one
CHEMBL457679
5 / 5 / 3 No. 15 No. 15
C00009887 External link 512 Gancaonin A
/ 5,7-Dihydroxy-4'-methoxy-6-prenylisoflavone
No. 15 No. 15
C00004996 External link 512 Topazolin
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-methoxy-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
No. 15 No. 15
C00010076 External link 512 Licocoumarone
CHEMBL611368
1 / 0 / 0 No. 15 No. 15
C00009831 External link 512 Isowighteone
/ 3'-Prenylgenistein
/ 5,7,4'-Trihydroxy-3'-prenylisoflavone
CHEMBL464460
2 / 1 / 1 No. 15 No. 15
C00019623 External link 512 Glyasperin N
/ 5,7,4'-Trihydroxy-8-prenyl-6'',6''-dimethylpyrano[2'',3'':2',3']isoflavone
No. 18 No. 15
C00009970 External link 512 3'-Dimethylallylkievitone
/ 5,7,2',4'-Tetrahydroxy-8,3'-diprenylisoflavanone
CHEMBL1711925
7 / 10 / 4 No. 19 No. 14
C00009880 External link 512 Semilicoisoflavone B
CHEMBL1864439
1 / 0 / 0 No. 24 No. 15
C00009497 External link 512 Licoisoflavone B
CHEMBL463741
No. 24 No. 15
C00019752 External link 512 Glyasperin B
/ 5,2',4'-Trihydroxy-7-methoxy-6-prenylisoflavanone
No. 28 No. 14
C00019620 External link 512 Glyasperin K
/ (S)-5,2'-Dihydroxy-7,4'-dimethoxy-6-prenylisoflavanone
No. 28 No. 14
C00019475 External link 512 Glyasperin M
No. 127 No. 14
C00009557 External link 512 Licoisoflavanone
No. 127 No. 14
C00019337 External link 512 Glyasperin D
CHEMBL1563332
7 / 7 / 3 No. 296 No. 14
C00009739 External link 512 Licoricidin
/ 5,2',4'-Trihydroxy-7-methoxy-6,3'-diprenylisoflavan
No. 296 No. 14
C00019753 External link 512 Glyasperin C
/ (3R)-7,2',4'-Trihydroxy-5-methoxy-6-prenylisoflavan
CHEMBL1630857
No. 296 No. 14
C00019622 External link 512 Glyasperin L
No. 377
C00010040 External link 512 Glycycoumarin
CHEMBL1223642
1 / 0 / 0 No. 436 No. 17
C00009777 External link 512 Glycyrol
/ Neoglycyrol
/ 1,9-Dihydroxy-3-methoxy-2-prenylcoumestan
C071429
No. 436 No. 17
C00010018 External link 512 1-Methoxyficifolinol
/ 3,9-Dihydroxy-1-methoxy-2,8-diprenylpterocarpan
No. 460
C00010036 External link 512 Licorisoflavan A
/ 7-O-Methyllicoricidin
/ (+)-2',4'-Dihydroxy-5,7-dimethoxy-6,3'-diprenylisoflavan
C076768
No. 794 No. 15

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00005010 C00009880 C00009970 C00019337 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00005010 C00009970 C00019337 2 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00009970 C00019337 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00009970 C00019337 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00010040 C00010076 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00009970 7 / 3
Q92731 Estrogen receptor beta NR3A2 C00009831 0 / 1
P37840 Alpha-synuclein Unclassified protein C00019337 4 / 2
P39748 Flap endonuclease 1 Enzyme C00019337 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005010 1 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00005010 2 / 2
P03372 Estrogen receptor NR3A1 C00009831 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005010 0 / 0
Q99700 Ataxin-2 Unclassified protein C00019337 1 / 1
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00009970 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00009970 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#615363 Estrogen resistance; estrr P03372
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (11)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)