Sophora substrata
Species
KNApSAcK Entry
| Organism name | Sophora substrata |
|---|---|
| Genus | Sophora |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Sophora |
|---|---|
| Linked NCBI taxonomy ID | 3896 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002553
|
Ononin
/ Formononetin 7-O-glucoside |
CHEMBL465980
|
11 / 14 / 40 | No. 2 | No. 15 |
|
||
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00002631
|
(+)-Lirioresinol B
/ (+)-Syringaresinol |
CHEMBL361362
CHEMBL402653 |
C042192
|
1 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00002546
|
Inermin
/ Maackiain / (-)-Maackiain / Demethylpterocarpin / 3-Hydroxy-8,9-methylenedioxypterocarpan |
CHEMBL334918
CHEMBL239047 CHEMBL445279 |
3 / 2 / 3 | No. 66 | No. 15 |
|
||
|
C00009616
|
Pterocarpin
/ 3-Methoxy-8,9-methylenedioxypterocarpan |
CHEMBL21103
CHEMBL242128 CHEMBL1983713 |
7 / 8 / 10 | No. 66 | No. 15 |
|
||
|
C00003800
|
7,4'-Dihydroxyflavone
|
CHEMBL294878
|
C085172
|
17 / 19 / 16 | No. 76 | No. 15 |
|
|
|
C00019186
|
(-)-Maackiain 3-sulfate
|
No. 7768 |
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00002546 C00009616 | 1 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002553 C00003800 | 1 / 1 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00002546 C00009616 | 1 / 1 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002553 C00003800 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002546 C00003800 | 0 / 1 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 C00003749 | 0 / 0 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002553 C00003800 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003800 C00009616 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003749 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00003800 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003800 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002553 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002553 | 4 / 2 |
| P15121 | Aldose reductase | Enzyme | C00002553 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00003800 | 2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00003800 | 5 / 3 |
| P06280 | Alpha-galactosidase A | Enzyme | C00003800 | 1 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003749 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00003800 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00003800 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002553 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002553 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003800 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002553 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00009616 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002553 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003800 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00003800 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00003800 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00009616 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00009616 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00009616 | 1 / 4 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003800 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002553 | 7 / 37 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #133239 | Esophageal cancer |
P04637
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
6 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006528 | Carcinoma, Hepatocellular |
C00003749
|
| D009202 | Cardiomyopathies |
C00003749
|
| D006937 | Hypercholesterolemia |
C00003749
|
| D009374 | Neoplasms, Experimental |
C00003749
|
| D012878 | Skin Neoplasms |
C00003749
|
| D014947 | Wounds and Injuries |
C00003749
|