PCIDB

Tetracentron sinense

Species

KNApSAcK Entry

Organism name Tetracentron sinense
Genus Tetracentron
Family Trochodendraceae / Tetracentraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tetracentron sinense
Linked NCBI taxonomy ID 13715
Linked level species

Family

Family in NCBI taxonomy Trochodendraceae
ID 4405

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00030742 External link 512 Maslinic acid
/ Crategolic acid
/ 2alpha,3beta-Dihydroxyolean-12-en-28-oic acid
CHEMBL201515
CHEMBL383749
CHEMBL482673
CHEMBL577380
C412811
8 / 5 / 4 No. 13 No. 51
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00003741 External link 512 Betulinic acid
CHEMBL269277
CHEMBL71690
CHEMBL519059
CHEMBL1318530
CHEMBL2005635
C002070
34 / 17 / 14 10 / 2 No. 23 No. 51
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00037278 External link 512 Huazhongilexin
CHEMBL466534
No. 38 No. 21
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00037900 External link 512 Tetracentronside A
/ (-)-Tetracentronside A
No. 122 No. 15
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00002599 External link 512 (-)-Dihydrocubebin
CHEMBL486597
CHEMBL1477391
C011228
4 / 8 / 4 No. 629 No. 21
C00029531 External link 512 Vanillic aldehyde
/ 4-Hydroxy-3-methoxybenzaldehyde
CHEMBL13883
C100058
18 / 8 / 9 33 / 1 No. 1003
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
CHEMBL120568
D014641
5 / 3 / 3 5 / 0 No. 1073
C00037901 External link 512 Tetracentronside B
/ (-)-Tetracentronside B
No. 6950

Human Protein / Gene in interactions

84 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003672 C00003741 C00019064 C00019308 0 / 0
P15121 Aldose reductase Enzyme C00002682 C00003741 C00019064 C00030742 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 C00019064 C00019308 C00030742 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 C00003741 C00019064 C00019308 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003741 C00019064 C00029531 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003741 C00019064 C00030742 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00003749 C00019308 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002599 C00003672 C00003741 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002599 C00003672 C00003741 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 C00003741 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002682 C00019064 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003741 C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003741 C00019064 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 C00030742 4 / 2
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00019064 C00030742 0 / 1
P03372 Estrogen receptor NR3A1 C00002682 C00003672 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002599 C00019064 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 C00003741 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 C00003741 2 / 0
P00734 Prothrombin S1A C00003672 C00019308 4 / 2
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00019064 C00030742 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 C00029531 1 / 1
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00019064 C00030742 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 C00003741 0 / 1
O75496 Geminin Unclassified protein C00003741 C00019064 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003741 C00003749 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00003741 C00003749 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003741 1 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019064 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00029531 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003741 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00019064 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00003741 0 / 0
P42858 Huntingtin Unclassified protein C00002682 1 / 1
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00003741 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00029531 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00029531 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003741 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002599 7 / 3
Q04206 Transcription factor p65 Transcription Factor C00003741 0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00029531 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00019064 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003741 0 / 0
Q02156 Protein kinase C epsilon type Eta C00003741 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019064 2 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00029531 1 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00029531 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00003741 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00029531 1 / 1
P55055 Oxysterols receptor LXR-beta NR1H3 C00003741 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00029531 2 / 2
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00029531 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00029531 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003741 0 / 0
P05771 Protein kinase C beta type Alpha C00003741 0 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00002682 1 / 1
P02545 Prelamin-A/C Unclassified protein C00003741 11 / 10
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00019064 0 / 0
P78527 DNA-dependent protein kinase catalytic subunit Atypical serine/threonine protein kinase PIKK subfamily C00029531 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00019064 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00029531 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00029531 0 / 0
P10275 Androgen receptor NR3C4 C00029531 3 / 4
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019064 0 / 3
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00029531 0 / 0
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00019064 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00003741 0 / 0
P11217 Glycogen phosphorylase, muscle form Enzyme C00030742 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003741 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003741 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00019064 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00019064 1 / 4
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00003741 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00003741 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00029531 0 / 0

61 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003741 C00019064
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002682 C00029531
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002682 C00029531
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002682 C00029531
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002682 C00029531
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00003741 C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00003741 C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003741 C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003741 C00019064
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003741
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00029531
759 CA1, CA-I, CAB, Car1 carbonic anhydrase I (EC:4.2.1.1) C00029531
760 CA2, CA-II, CAC, CAII, Car2 carbonic anhydrase II (EC:4.2.1.1) C00029531
1196 CLK2, hCLK2 CDC-like kinase 2 (EC:2.7.12.1) C00029531
1490 CTGF, CCN2, HCS24, IGFBP8, NOV2 connective tissue growth factor C00029531
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00029531
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00029531
1789 DNMT3B, ICF, ICF1, M.HsaIIIB DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) C00029531
1848 DUSP6, HH19, MKP3, PYST1 dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48) C00029531
2263 FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 fibroblast growth factor receptor 2 (EC:2.7.10.1) C00029531
2535 FZD2, Fz2, fz-2, fzE2, hFz2 frizzled family receptor 2 C00029531
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00029531
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00029531
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00029531
3251 HPRT1, HGPRT, HPRT hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8) C00029531
3304 HSPA1B, HSP70-1B, HSP70-2 heat shock 70kDa protein 1B C00029531
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00029531
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00029531
3727 JUND, AP-1 jun D proto-oncogene C00029531
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00029531
57787 MARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D MAP/microtubule affinity-regulating kinase 4 (EC:2.7.11.1) C00029531
4502 MT2A, MT2 metallothionein 2A C00029531
5514 PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99 protein phosphatase 1, regulatory subunit 10 C00029531
11046 SLC35D2, HFRC1, SQV7L, UGTrel8, hfrc solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 C00029531
23657 SLC7A11, CCBR1, xCT solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 C00029531
7041 TGFB1I1, ARA55, HIC-5, HIC5, TSC-5 transforming growth factor beta 1 induced transcript 1 C00029531
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00029531
10626 TRIM16, EBBP tripartite motif containing 16 C00029531
7360 UGP2, UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9) C00029531
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00003741
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003741
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00003741
581 BAX, BCL2L4 BCL2-associated X protein C00003741
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00019064
847 CAT catalase (EC:1.11.1.6) C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002682

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (57)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613163 Gaba-transaminase deficiency P80404
#137800 Glioma susceptibility 1; glm1 O75874
#232600 Glycogen storage disease v P11217
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#156250 Metachondromatosis; metcds Q06124
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#163950 Noonan syndrome 1; ns1 Q06124
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#610460 Thiopurine s-methyltransferase deficiency P51580
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (49)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00069 Glycogen storage diseases (GSD) P11217 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35228 (related)
P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

26 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008103 Liver Cirrhosis C00003741
C00019064
D056486 Drug-Induced Liver Injury C00019064
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308
D008113 Liver Neoplasms C00029531
D002252 Carbon Tetrachloride Poisoning C00019064
D008545 Melanoma C00003741
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D006949 Hyperlipidemias C00019064
D007249 Inflammation C00019064
D007674 Kidney Diseases C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D017202 Myocardial Ischemia C00019064
D009369 Neoplasms C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064