Species

KNApSAcK Entry

Organism name Daphne tangutica
Genus Daphne
Family Thymelaeaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Daphne tangutica
Linked NCBI taxonomy ID 885948
Linked level species

Family

Family in NCBI taxonomy Thymelaeaceae
ID 39987

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000587 External link 512 (-)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
7 / 5 / 6 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00003433 External link 512 Gniditrin
CHEMBL1159653
C010461
No. 401 No. 41
C00002986 External link 512 Daphneticin
CHEMBL584162
No. 485
C00000602 External link 512 (+)-Lariciresinol
CHEMBL518421
2 / 1 / 1 No. 700 No. 21
C00000603 External link 512 (-)-Lariciresinol
CHEMBL518421
C060282
2 / 1 / 1 No. 700 No. 21
C00045589 External link 512 7-Hydroxy-8-methoxycoumarin
CHEMBL2331585
6 / 2 / 4 No. 864 No. 25
C00002462 External link 512 Daphnetin
CHEMBL244948
C039952
40 / 43 / 40 No. 1030 No. 25
C00002463 External link 512 Daphnoretin
CHEMBL508494
C035316
14 / 11 / 10 No. 1906 No. 25

Human Protein / Gene in interactions

54 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000602 C00000603 C00002462 C00002463 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000587 C00002462 C00007190 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000602 C00000603 C00002462 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002462 C00002463 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00002462 C00002463 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000587 C00007190 0 / 3
P06746 DNA polymerase beta Enzyme C00002462 C00002463 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00000587 C00007190 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000587 C00007190 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002462 C00002463 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000587 C00007190 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002462 C00002463 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002462 C00002463 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002462 C00002463 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002462 C00002463 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002462 C00002463 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002462 C00002463 3 / 3
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000587 C00007190 5 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002462 C00002463 0 / 0
O75496 Geminin Unclassified protein C00002462 C00002463 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000587 C00007190 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002462 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00045589 1 / 2
P39748 Flap endonuclease 1 Enzyme C00002462 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002462 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002462 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00045589 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002462 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00002462 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002462 1 / 8
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002462 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00045589 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002463 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002462 0 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00002462 5 / 2
P00918 Carbonic anhydrase 2 Lyase C00045589 1 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00002462 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002462 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00002462 3 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002462 1 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00002462 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002462 11 / 10
Q8N1Q1 Carbonic anhydrase 13 Lyase C00045589 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00002462 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00045589 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00002462 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002462 2 / 0
P40225 Thrombopoietin Unclassified protein C00002462 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002462 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002462 4 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002462 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002462 1 / 4
Q9Y253 DNA polymerase eta Enzyme C00002462 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#601665 Obesity P37231
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (48)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)