Erythrina senegalensis
Species
KNApSAcK Entry
| Organism name | Erythrina senegalensis |
|---|---|
| Genus | Erythrina |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Erythrina senegalensis |
|---|---|
| Linked NCBI taxonomy ID | 157649 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (31)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00019064
|
Oleanolic acid
/ Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid |
CHEMBL56615
CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454 |
D009828
|
30 / 8 / 12 | 21 / 15 | No. 13 | No. 51 |
|
|
C00019065
|
Erythrodiol
/ 3beta-Erythrodiol |
CHEMBL298604
CHEMBL60687 CHEMBL400074 |
C077953
|
4 / 0 / 1 | No. 13 | No. 51 |
|
|
|
C00019526
|
Cornulactic acid
|
CHEMBL210970
CHEMBL559587 |
1 / 0 / 0 | No. 13 | No. 51 |
|
||
|
C00019525
|
Maniladiol
/ 3beta,16beta-Dihydroxyolean-12-ene |
CHEMBL1977415
|
C068534
|
No. 13 | No. 51 |
|
||
|
C00019103
|
Erysenegalensein D
|
No. 14 | No. 15 |
|
||||
|
C00019062
|
Erysenegalensein E
|
CHEMBL557493
|
No. 14 | No. 15 |
|
|||
|
C00009516
|
6,8-Diprenylgenistein
/ 8-(gamma,gamma-Dimethylallyl)wighteone / 5,7,4'-Trihydroxy-6,8-diprenylisoflavone |
CHEMBL494252
|
12 / 14 / 11 | No. 14 | No. 15 |
|
||
|
C00019101
|
Erysenegalensein N
/ 5,7,2',4'-Tetrahydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-8-prenylisoflavone |
No. 14 | No. 15 |
|
||||
|
C00019524
|
Erysenegalensein K
/ 5,2',4'-Trihydroxy-8-prenylfurano[2'',3'':7,6]coumaronochromone |
No. 15 | No. 15 |
|
||||
|
C00019626
|
7,6]isoflavone
/ Erysenegalensein F / 5,2',4'-Trihydroxy-8-(2,3-epoxy-3-methylbutyl)-6'',6''-dimethylpyrano[2'',3'' |
No. 18 | No. 15 |
|
||||
|
C00009521
|
Auriculatin
|
No. 18 | No. 15 |
|
||||
|
C00019514
|
Erysenegalensein L
/ 5,2',4'-Trihydroxy-8-(2'''-hydroxy-3'''-methyl-3'''-butenyl)-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone |
No. 18 | No. 15 |
|
||||
|
C00000954
|
Senegalensein
/ Lonchocarpol A / 6,8-Diprenylnaringenin |
CHEMBL477969
CHEMBL1545584 |
C068505
|
16 / 26 / 18 | No. 19 | No. 14 |
|
|
|
C00018995
|
Erysengalensein B
/ 5,7,2',4',5'-Pentahydroxy-6,8-di-(gamma,gamma-dimethylallyl)isoflavanone |
No. 19 | No. 14 |
|
||||
|
C00003738
|
beta-Amyrin
/ beta-Amirin / beta-Amyrine / beta-Amyrenol |
C036380
|
0 / 4 | No. 23 | No. 51 |
|
||
|
C00009493
|
Derrone
|
CHEMBL393223
|
No. 24 | No. 15 |
|
|||
|
C00009492
|
Alpinumisoflavone
|
CHEMBL238628
|
C000154
|
3 / 1 / 1 | 1 / 0 | No. 24 | No. 15 |
|
|
C00008262
|
Lupinifolin
|
CHEMBL559980
|
No. 39 |
|
||||
|
C00009971
|
2,3-Dihydroauriculatin
/ 5,2',4'-Trihydroxy-8-prenyl-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavanone |
C050248
|
No. 39 |
|
||||
|
C00018996
|
Erysengalensein C
/ 5,2',4'-Trihydroxy-5'-methoxy-8-(gamma,gamma-dimethylallyl)-2'',2''-dimethylpyrano[5'',6'':6,7]isoflavanone |
No. 39 |
|
|||||
|
C00008249
|
Cajaflavanone
/ Erythrisenegalone |
CHEMBL557692
|
No. 39 |
|
||||
|
C00009945
|
Senegalensin
|
CHEMBL565072
|
No. 47 | No. 15 |
|
|||
|
C00019102
|
Erysenegalensein O
/ 5,2',4',5''-Tetrahydroxy-6-prenyl-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,8]isoflavone |
No. 47 | No. 15 |
|
||||
|
C00019760
|
Erysenegalensein H
/ 5,2'4'-Trihydroxy-5''-(1-hydroxy-1-methylethyl)-8-prenyl-4'',5''-dihydrofurano[2'',3'',7,6]isoflavone |
No. 47 | No. 15 |
|
||||
|
C00019761
|
Erysenegalensein I
/ 5,2',4'-Trihydroxy-8-prenyl-6'',6''-dimethyl-4'',5''-dihydropyrano[2'',3'':7,6]isoflavone |
No. 47 | No. 15 |
|
||||
|
C00001852
|
Erythratidine
|
No. 273 | No. 4 |
|
||||
|
C00019515
|
Erysodin
/ Erysodine |
CHEMBL446533
|
C097135
|
No. 446 | No. 4 |
|
||
|
C00001851
|
Erysotrine
|
CHEMBL442947
|
No. 446 | No. 4 |
|
|||
|
C00019523
|
Erysenegalensein J
|
No. 1072 |
|
|||||
|
C00001740
|
Hypaphorine
|
CHEMBL503867
CHEMBL448328 |
C001529
|
3 / 1 / 1 | No. 1432 | No. 4 |
|
|
|
C00019516
|
Glycoerysodin
|
No. 4244 |
|
Human Protein / Gene in interactions
50 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00009492 C00019064 C00019065 C00019526 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000954 C00009516 C00019064 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000954 C00001740 C00019064 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00000954 C00009516 | 6 / 4 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00019064 C00019065 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000954 C00009516 | 4 / 3 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00019064 C00019065 | 0 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000954 C00009516 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001740 C00019064 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000954 C00009516 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00009516 C00019064 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000954 C00009516 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00019064 C00019065 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000954 C00009516 | 1 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000954 C00009516 | 2 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00019064 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000954 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00019064 | 0 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00019064 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00009492 | 0 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00019064 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00019064 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00019064 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000954 | 7 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00019064 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00019064 | 2 / 2 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00019064 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00019064 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00009516 | 0 / 0 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00019064 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00009492 | 1 / 1 |
| P35228 | Nitric oxide synthase, inducible | Enzyme | C00019064 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00019064 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00019064 | 4 / 2 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001740 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00019064 | 0 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00009516 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000954 | 0 / 0 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00019064 | 0 / 0 |
| P04054 | Phospholipase A2 | Enzyme | C00019064 | 0 / 0 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00019064 | 0 / 0 |
| P17861 | X-box-binding protein 1 | Unclassified protein | C00000954 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00000954 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000954 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00019064 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00019064 | 1 / 4 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00009516 | 0 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000954 | 1 / 1 |
22 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00009492
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00019064
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00019064
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00019064
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00019064
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00019064
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00019064
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00019064
|
| 3065 | HDAC1, GON-10, HD1, RPD3, RPD3L1 | histone deacetylase 1 (EC:3.5.1.98) |
C00019064
|
| 3146 | HMGB1, HMG1, HMG3, SBP-1 | high mobility group box 1 |
C00019064
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00019064
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00019064
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00019064
|
| 4233 | MET, AUTS9, HGFR, RCCP2, c-Met | met proto-oncogene (EC:2.7.10.1) |
C00019064
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00019064
|
| 5052 | PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 | peroxiredoxin 1 (EC:1.11.1.15) |
C00019064
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00019064
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00019064
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00019064
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00019064
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00019064
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00019064
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (36)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #612371 | Major affective disorder 7; mafd7 |
P17861
|
| #611162 | Malaria, susceptibility to |
P35228
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (34)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H00017 | Esophageal cancer |
P35228
(related)
P35354 (related) |
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
Diseases related to CTD interactions
18 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007249 | Inflammation |
C00003738
C00019064 |
| D007674 | Kidney Diseases |
C00019064
|
| D005157 | Facial Pain |
C00003738
|
| D010146 | Pain |
C00003738
|
| D002252 | Carbon Tetrachloride Poisoning |
C00019064
|
| D056486 | Drug-Induced Liver Injury |
C00019064
|
| D050171 | Dyslipidemias |
C00019064
|
| D018149 | Glucose Intolerance |
C00019064
|
| D006949 | Hyperlipidemias |
C00019064
|
| D006930 | Hyperalgesia |
C00003738
|
| D008103 | Liver Cirrhosis |
C00019064
|
| D008106 | Liver Cirrhosis, Experimental |
C00019064
|
| D008107 | Liver Diseases |
C00019064
|
| D017202 | Myocardial Ischemia |
C00019064
|
| D009369 | Neoplasms |
C00019064
|
| D009765 | Obesity |
C00019064
|
| D011041 | Poisoning |
C00019064
|
| D011230 | Precancerous Conditions |
C00019064
|