Ophiorrhiza liukiuensis
Species
KNApSAcK Entry
| Organism name | Ophiorrhiza liukiuensis |
|---|---|
| Genus | Ophiorrhiza |
| Family | Rubiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ophiorrhiza liukiuensis |
|---|---|
| Linked NCBI taxonomy ID | 489897 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Rubiaceae |
|---|---|
| ID | 24966 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (19)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00029372
|
10-Methoxycamptothecin:(-)-10-Methoxycamptothecin
|
C025724
|
|
|||||
|
C00029329
|
Roseoside
/ Roseoside A / Roseoside II / (6S,9R)-Roseoside / Vomifoliol beta-D-glucopyranoside |
|
||||||
|
C00005372
|
Hyperin
/ Hyperoside / Quercetin 3-O-galactoside / Quercetin 3-O-beta-D-galactoside / Quercetin 3-beta-galactopyranoside / Quercetin 3-O-beta-D-galactopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
C021304
|
38 / 43 / 34 | 4 / 0 | No. 2 | No. 15 |
|
|
C00003558
|
Ursolic acid
|
CHEMBL297810
CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720 |
C005466
|
47 / 26 / 33 | 15 / 12 | No. 13 | No. 51 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00003088
|
Loganin
|
CHEMBL1081584
CHEMBL1081586 CHEMBL1589904 CHEMBL2135791 |
C059516
|
2 / 1 / 1 | 0 / 1 | No. 56 | No. 36 |
|
|
C00010604
|
Loganic acid
|
CHEMBL1081585
CHEMBL1079678 CHEMBL1356464 CHEMBL1452775 |
C002947
|
6 / 8 / 7 | No. 64 | No. 36 |
|
|
|
C00002724
|
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
|
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00031110
|
Pumiloside
|
No. 577 | No. 4 |
|
||||
|
C00029323
|
Deoxypumiloside
/ 3(R)-Deoxypumiloside / (3R)-Deoxypumiloside |
No. 577 | No. 4 |
|
||||
|
C00032210
|
Strictosamide
|
CHEMBL480522
|
No. 577 | No. 4 |
|
|||
|
C00002499
|
Scopoletin
|
CHEMBL71851
|
D012603
|
48 / 37 / 34 | 9 / 0 | No. 864 | No. 25 |
|
|
C00030891
|
Ophiorine B
|
No. 934 |
|
|||||
|
C00030697
|
Lyalosidic acid
|
No. 934 |
|
|||||
|
C00030889
|
Ophiorine A
|
No. 934 |
|
|||||
|
C00001736
|
Harman
/ Harmane / Indoter / Locuturin / Zygofabagine |
CHEMBL12014
|
C005010
|
109 / 46 / 33 | 2 / 2 | No. 1889 | No. 4 |
|
|
C00002145
|
Camptothecin
|
CHEMBL65
CHEMBL276820 CHEMBL71836 |
D002166
|
140 / 99 / 97 | 79 / 11 | No. 3696 | No. 7 |
|
|
C00029611
|
9-Methoxycamptothecin
|
CHEMBL91945
CHEMBL522112 |
1 / 0 / 0 | No. 3696 | No. 7 |
|
Human Protein / Gene in interactions
306 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001736 C00002145 C00002499 C00002724 C00003558 C00003672 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001736 C00002145 C00002499 C00002724 C00003558 C00003672 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001736 C00002145 C00002499 C00002724 C00003558 C00003672 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001736 C00002145 C00002499 C00002724 C00003558 C00003672 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001736 C00002145 C00002499 C00002724 C00003558 C00003672 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002145 C00002499 C00002724 C00003558 C00005372 | 0 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001736 C00002145 C00002499 C00002724 C00005372 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002145 C00002499 C00002724 C00003088 C00005372 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001736 C00002145 C00002499 C00003558 | 1 / 2 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002145 C00002499 C00002724 C00005372 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001736 C00002145 C00002499 C00002724 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002499 C00002724 C00003558 C00005372 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001736 C00002145 C00002499 C00003558 | 2 / 5 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001736 C00002145 C00002724 C00003672 | 3 / 2 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00001736 C00003558 C00003672 C00019308 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001736 C00002145 C00002499 C00002724 | 3 / 3 |
| P06746 | DNA polymerase beta | Enzyme | C00003558 C00003672 C00005372 C00019308 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00002499 C00003558 C00003672 C00019308 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001736 C00002724 C00003558 C00005372 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001736 C00005372 C00010604 | 4 / 3 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002145 C00002499 C00005372 | 1 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002145 C00002499 C00003558 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002145 C00002724 C00010604 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001736 C00002145 C00005372 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002145 C00003558 C00005372 | 11 / 10 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001736 C00002145 C00005372 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003558 C00003672 C00019308 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002724 C00003558 C00005372 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001736 C00002145 C00003558 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002145 C00002499 C00005372 | 6 / 4 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001736 C00002145 C00003672 | 2 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002145 C00002499 C00005372 | 1 / 1 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001736 C00002145 C00002499 | 1 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001736 C00002145 C00002499 | 2 / 2 |
| P29466 | Caspase-1 | C14 | C00002145 C00002499 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003558 C00005372 | 1 / 4 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001736 C00002145 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001736 C00002145 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002145 C00003672 | 1 / 1 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002145 C00005372 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003558 C00005372 | 0 / 1 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001736 C00002145 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00001736 C00002145 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002145 C00002724 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00005372 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002145 C00002724 | 0 / 1 |
| P00734 | Prothrombin | S1A | C00003672 C00019308 | 4 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002145 C00003558 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002145 C00002724 | 0 / 1 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00002499 C00003558 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00002724 C00003558 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002145 C00002499 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003558 C00003672 | 1 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002499 C00005372 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002145 C00005372 | 4 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002145 C00002499 | 1 / 2 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002145 C00005372 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002499 C00002724 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002499 C00003558 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002724 C00003672 | 1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002145 C00002499 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003558 C00010604 | 1 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002145 C00005372 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002145 C00005372 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002145 C00003558 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002145 C00029611 | 0 / 0 |
| P60033 | CD81 antigen | Unclassified protein | C00003088 C00010604 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00002145 C00003672 | 1 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002145 C00005372 | 1 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001736 C00002145 | 1 / 2 |
| P17252 | Protein kinase C alpha type | Alpha | C00001736 C00002145 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002145 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002145 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002145 | 0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00001736 | 0 / 0 |
| Q00535 | Cyclin-dependent kinase 5 | Cdk5 | C00001736 | 0 / 0 |
| Q9UQB9 | Aurora kinase C | Aur | C00001736 | 1 / 1 |
| Q9HBH9 | MAP kinase-interacting serine/threonine-protein kinase 2 | CAMK serine/threonine protein kinase MNK subfamily | C00001736 | 0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | C00001736 | 0 / 0 |
| Q16644 | MAP kinase-activated protein kinase 3 | CAMK serine/threonine protein kinase MAPKAPK | C00001736 | 0 / 0 |
| Q9H422 | Homeodomain-interacting protein kinase 3 | CMGC dual-specificity kinase HIPK | C00001736 | 0 / 0 |
| Q14680 | Maternal embryonic leucine zipper kinase | Melk | C00001736 | 0 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005372 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001736 | 0 / 0 |
| Q9HBX9 | Relaxin receptor 1 | Relaxin receptor | C00002145 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002145 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00001736 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002145 | 1 / 8 |
| P02768 | Serum albumin | Secreted protein | C00002145 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00002145 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002145 | 2 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00001736 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002145 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002145 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002145 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002145 | 0 / 0 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | C00001736 | 1 / 1 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | C00001736 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002145 | 0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00001736 | 2 / 2 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00001736 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002145 | 1 / 1 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00001736 | 0 / 0 |
| Q16513 | Serine/threonine-protein kinase N2 | Pkn | C00001736 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00001736 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001736 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002145 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002145 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002145 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00003558 | 1 / 1 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00002145 | 4 / 4 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002499 | 1 / 2 |
| Q9UQL6 | Histone deacetylase 5 | Hydrolase | C00003558 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00005372 | 1 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002145 | 0 / 0 |
| Q8N5S9 | Calcium/calmodulin-dependent protein kinase kinase 1 | META serine/threonine protein kinase subfamily | C00001736 | 0 / 0 |
| Q9P286 | Serine/threonine-protein kinase PAK 7 | STE serine/threonine protein kinase PAKB subfamily | C00001736 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002145 | 1 / 0 |
| Q96SB4 | SRSF protein kinase 1 | Srpk | C00001736 | 0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | C00001736 | 0 / 0 |
| O43781 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | CMGC dual-specificity kinase DYRK2 | C00001736 | 0 / 0 |
| O96013 | Serine/threonine-protein kinase PAK 4 | STE serine/threonine protein kinase PAKB subfamily | C00001736 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005372 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002145 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002145 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00010604 | 2 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002145 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002145 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002145 | 1 / 1 |
| P09651 | Heterogeneous nuclear ribonucleoprotein A1 | Unclassified protein | C00002145 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002499 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002145 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002145 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002145 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002145 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002145 | 1 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002145 | 0 / 1 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002145 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002145 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003558 | 3 / 1 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002145 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002145 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002145 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002499 | 0 / 0 |
| Q9NZJ5 | Eukaryotic translation initiation factor 2-alpha kinase 3 | Pek | C00002145 | 1 / 2 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002145 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002145 | 0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | C00001736 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00001736 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002145 | 1 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | C00001736 | 0 / 1 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
| P03956 | Interstitial collagenase | M10A | C00002145 | 0 / 1 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | C00001736 | 0 / 0 |
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | META serine/threonine protein kinase subfamily | C00001736 | 0 / 0 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002145 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002499 | 7 / 3 |
| Q9BUB5 | MAP kinase-interacting serine/threonine-protein kinase 1 | CAMK serine/threonine protein kinase MNK subfamily | C00001736 | 0 / 0 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00002499 | 1 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005372 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005372 | 0 / 0 |
| P42226 | Signal transducer and activator of transcription 6 | Unclassified protein | C00002145 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005372 | 3 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003558 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003558 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003558 | 0 / 0 |
| P27448 | MAP/microtubule affinity-regulating kinase 3 | CAMK serine/threonine protein kinase MARK subfamily | C00001736 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002145 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002145 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00003558 | 2 / 2 |
| Q8IWQ3 | Serine/threonine-protein kinase BRSK2 | CAMK serine/threonine protein kinase BRSK subfamily | C00001736 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002145 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002145 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002145 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002145 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002145 | 0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | C00001736 | 1 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002145 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002145 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002145 | 0 / 0 |
| P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00003558 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00001736 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00001736 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003558 | 0 / 0 |
| O15379 | Histone deacetylase 3 | Hydrolase | C00003558 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002145 | 1 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002499 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005372 | 0 / 1 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002145 | 2 / 1 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00001736 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002499 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002499 | 0 / 1 |
| Q13547 | Histone deacetylase 1 | Hydrolase | C00003558 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005372 | 2 / 0 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002145 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00002145 | 5 / 2 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002499 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002499 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002499 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002145 | 0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00001736 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002145 | 1 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002499 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002145 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002145 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00001736 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002145 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002145 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002145 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00001736 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002145 | 0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00001736 | 0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | C00001736 | 0 / 0 |
| P56524 | Histone deacetylase 4 | Hydrolase | C00003558 | 1 / 1 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002499 | 0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00001736 | 0 / 0 |
| P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00003558 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00002145 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002145 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002499 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00001736 | 4 / 1 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00001736 | 0 / 0 |
| P51812 | Ribosomal protein S6 kinase alpha-3 | Rskb | C00001736 | 2 / 2 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002145 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002724 | 3 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| Q9HC98 | Serine/threonine-protein kinase Nek6 | Nek | C00001736 | 0 / 0 |
| Q9H2X6 | Homeodomain-interacting protein kinase 2 | CMGC dual-specificity kinase HIPK | C00001736 | 0 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00001736 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00001736 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002724 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002145 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002499 | 5 / 1 |
| P08246 | Neutrophil elastase | S1A | C00002145 | 2 / 1 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00002145 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002145 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005372 | 1 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002145 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002145 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002145 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003558 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002145 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002145 | 1 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002499 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00003558 | 0 / 1 |
| O96017 | Serine/threonine-protein kinase Chk2 | Rad53 | C00001736 | 4 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002145 | 0 / 0 |
| Q14012 | Calcium/calmodulin-dependent protein kinase type 1 | Camk1 | C00001736 | 0 / 0 |
| Q9UBN7 | Histone deacetylase 6 | Hydrolase | C00003558 | 0 / 0 |
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00003558 | 0 / 0 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005372 | 1 / 1 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00001736 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00001736 | 1 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00002145 | 5 / 5 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00001736 | 0 / 0 |
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | C00001736 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002499 | 0 / 0 |
| P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
| Q8TD08 | Mitogen-activated protein kinase 15 | Mapk | C00001736 | 0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | C00001736 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005372 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005372 | 0 / 0 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005372 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00002145 | 1 / 1 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
| Q8TDX7 | Serine/threonine-protein kinase Nek7 | Nek | C00001736 | 0 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00002499 | 1 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002145 | 0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00001736 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002145 | 7 / 37 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002499 | 3 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00001736 | 1 / 1 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001736 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001736 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001736 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001736 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001736 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001736 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001736 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001736 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001736 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001736 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001736 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001736 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001736 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001736 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001736 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001736 | 1 / 0 |
| P20248 | Cyclin-A2 | Other cytosolic protein | C00001736 | 0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | C00001736 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00001736 | 0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | C00001736 | 0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | C00001736 | 0 / 0 |
| P30874 | Somatostatin receptor type 2 | Somatostatin receptor | C00002145 | 0 / 0 |
| P31391 | Somatostatin receptor type 4 | Somatostatin receptor | C00002145 | 0 / 0 |
| P32745 | Somatostatin receptor type 3 | Somatostatin receptor | C00002145 | 0 / 0 |
| P35346 | Somatostatin receptor type 5 | Somatostatin receptor | C00002145 | 0 / 0 |
| P30872 | Somatostatin receptor type 1 | Somatostatin receptor | C00002145 | 0 / 0 |
| Q92698 | DNA repair and recombination protein RAD54-like | Enzyme | C00001736 | 0 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00002145 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00010604 | 0 / 3 |
133 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002145
C00003558
C00005372
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002145
C00003558
C00005372
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002145
C00003558
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002499
C00002724
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002499
C00002724
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002499
C00002724
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002145
C00003558
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002145
C00003558
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002499
C00002724
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00002145
C00003558
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00002145
C00003558
|
| 114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003558
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003558
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00003558
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00003558
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003558
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00005372
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00005372
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002145
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002145
|
| 375790 | AGRN | agrin |
C00002145
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00002145
|
| 307 | ANXA4, ANX4, PIG28, ZAP36 | annexin A4 |
C00002145
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00002145
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00002145
|
| 672 | BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 | breast cancer 1, early onset |
C00002145
|
| 675 | BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2 | breast cancer 2, early onset |
C00002145
|
| 51719 | CAB39, MO25 | calcium binding protein 39 |
C00002145
|
| 835 | CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 | caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) |
C00002145
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002145
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002145
|
| 6351 | CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 | chemokine (C-C motif) ligand 4 |
C00002145
|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00002145
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00002145
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00002145
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002145
|
| 634 | CEACAM1, BGP, BGP1, BGPI | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
C00002145
|
| 10153 | CEBPZ, CBF, CBF2, HSP-CBF, NOC1 | CCAAT/enhancer binding protein (C/EBP), zeta |
C00002145
|
| 1508 | CTSB, APPS, CPSB | cathepsin B (EC:3.4.22.1) |
C00002145
|
| 1806 | DPYD, DHP, DHPDHASE, DPD | dihydropyrimidine dehydrogenase (EC:1.3.1.2) |
C00002145
|
| 9538 | EI24, EPG4, PIG8, TP53I8 | etoposide induced 2.4 |
C00002145
|
| 2033 | EP300, KAT3B, RSTS2, p300 | E1A binding protein p300 (EC:2.3.1.48) |
C00002145
|
| 9852 | EPM2AIP1 | EPM2A (laforin) interacting protein 1 |
C00002145
|
| 2067 | ERCC1, COFS4, RAD10, UV20 | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
C00002145
|
| 2072 | ERCC4, ERCC11, FANCQ, RAD1, XPF | excision repair cross-complementing rodent repair deficiency, complementation group 4 |
C00002145
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002145
|
| 2232 | FDXR, ADXR | ferredoxin reductase (EC:1.18.1.6) |
C00002145
|
| 2395 | FXN, CyaY, FA, FARR, FRDA, X25 | frataxin (EC:1.16.3.1) |
C00002145
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00002145
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00002145
|
| 3183 | HNRNPC, C1, C2, HNRNP, HNRPC, SNRPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) |
C00002145
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00002145
|
| 3570 | IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80 | interleukin 6 receptor |
C00002145
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002145
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00002145
|
| 3956 | LGALS1, GAL1, GBP | lectin, galactoside-binding, soluble, 1 |
C00002145
|
| 5606 | MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2 | mitogen-activated protein kinase kinase 3 (EC:2.7.12.2) |
C00002145
|
| 4217 | MAP3K5, ASK1, MAPKKK5, MEKK5 | mitogen-activated protein kinase kinase kinase 5 (EC:2.7.11.25) |
C00002145
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002145
|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00002145
|
| 4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00002145
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00002145
|
| 406929 | MIR138-1, MIRN138-1 | microRNA 138-1 |
C00002145
|
| 8440 | NCK2, GRB4, NCKbeta | NCK adaptor protein 2 |
C00002145
|
| 1263 | PLK3, CNK, FNK, PRK | polo-like kinase 3 (EC:2.7.11.21) |
C00002145
|
| 84152 | PPP1R1B, DARPP-32, DARPP32 | protein phosphatase 1, regulatory (inhibitor) subunit 1B (EC:3.1.3.16) |
C00002145
|
| 9055 | PRC1, ASE1 | protein regulator of cytokinesis 1 |
C00002145
|
| 5888 | RAD51, BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA | RAD51 recombinase |
C00002145
|
| 5889 | RAD51C, BROVCA3, FANCO, R51H3, RAD51L2 | RAD51 paralog C |
C00002145
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002145
|
| 5933 | RBL1, CP107, PRB1, p107 | retinoblastoma-like 1 (p107) |
C00002145
|
| 5934 | RBL2, P130, Rb2 | retinoblastoma-like 2 (p130) |
C00002145
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002145
|
| 6382 | SDC1, CD138, SDC, SYND1, syndecan | syndecan 1 |
C00002145
|
| 6606 | SMN1, BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3, SMA4, SMA@, SMN, SMNT, T-BCD541, TDRD16A | survival of motor neuron 1, telomeric |
C00002145
|
| 55512 | SMPD3, NSMASE2 | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (EC:3.1.4.12) |
C00002145
|
| 6667 | SP1 | Sp1 transcription factor |
C00002145
|
| 6670 | SP3, SPR2 | Sp3 transcription factor |
C00002145
|
| 6890 | TAP1, ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
C00002145
|
| 30851 | TAX1BP3, TIP-1 | Tax1 (human T-cell leukemia virus type I) binding protein 3 |
C00002145
|
| 55775 | TDP1 | tyrosyl-DNA phosphodiesterase 1 (EC:3.1.4.-) |
C00002145
|
| 7057 | THBS1, THBS, THBS-1, TSP, TSP-1, TSP1 | thrombospondin 1 |
C00002145
|
| 8744 | TNFSF9, 4-1BB-L, CD137L | tumor necrosis factor (ligand) superfamily, member 9 |
C00002145
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002145
|
| 9540 | TP53I3, PIG3 | tumor protein p53 inducible protein 3 |
C00002145
|
| 11257 | TP53TG1, LINC00096, NCRNA00096, P53TG1, P53TG1-D, TP53AP1 | TP53 target 1 (non-protein coding) |
C00002145
|
| 7298 | TYMS, HST422, TMS, TS | thymidylate synthetase (EC:2.1.1.45) |
C00002145
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002145
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002145
|
| 7518 | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 |
C00002145
|
| 47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
| 358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
| 360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
| 4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00003558
|
| 1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
| 2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
| 2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00002724
|
| 3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
| 3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
| 3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
| 8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
| 5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
| 7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
|
| 7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001736
|
| 578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00003558
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00003558
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001736
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002499
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00002499
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002499
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002499
|
| 7508 | XPC, RAD4, XP3, XPCC | xeroderma pigmentosum, complementation group C |
C00002499
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (180)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 P47869 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #609135 | Aplastic anemia |
O14746
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #600430 | Brachydactyly-mental retardation syndrome; bdmr |
P56524
|
| #114480 | Breast cancer |
O96017
P31749 |
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #303600 | Coffin-lowry syndrome; cls |
P51812
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #226980 | Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus |
Q9NZJ5
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #613496 | Immunodeficiency, common variable, 6; cvid6 |
P60033
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #609265 | Li-fraumeni syndrome 2; lfs2 |
O96017
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300844 | Mental retardation, x-linked 19; mrx19 |
P51812
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #159900 | Myoclonic dystonia |
P14416
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259500 | Osteogenic sarcoma |
O96017
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #176807 | Prostate cancer |
O96017
|
| #176920 | Proteus syndrome |
P31749
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #603903 | Sickle cell anemia |
P68871
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #243060 | Spermatogenic failure 5; spgf5 |
Q9UQB9
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (137)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P00533 (related) P04626 (related) P04637 (related) P68871 (marker) |
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00881 | Li-Fraumeni syndrome |
O96017
(related)
P04637 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P31751 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) P31751 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P68871 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
P51812 (related) Q99714 (related) |
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00574 | Coffin-Lowry syndrome (CLS) |
P51812
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00561 | Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome |
P56524
(related)
|
| H00088 | Common variable immunodeficiency (CVID) |
P60033
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00512 | Permanent neonatal diabetes mellitus (PNDM) |
Q9NZJ5
(related)
|
| H00766 | Wolcott-Rallison syndrome |
Q9NZJ5
(related)
|
| H01282 | Spermatogenic failure |
Q9UQB9
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
37 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D009369 | Neoplasms |
C00003558
C00002145 |
| D003967 | Diarrhea |
C00002145
|
| D001284 | Atrophy |
C00003558
|
| D006528 | Carcinoma, Hepatocellular |
C00003558
|
| D002471 | Cell Transformation, Neoplastic |
C00003558
|
| D003921 | Diabetes Mellitus, Experimental |
C00003558
|
| D006943 | Hyperglycemia |
C00003558
|
| D006949 | Hyperlipidemias |
C00003558
|
| D006965 | Hyperplasia |
C00003558
|
| D007249 | Inflammation |
C00003558
|
| D008103 | Liver Cirrhosis |
C00003558
|
| D017202 | Myocardial Ischemia |
C00003558
|
| D012640 | Seizures |
C00001736
|
| D012878 | Skin Neoplasms |
C00003558
|
| D002493 | Central Nervous System Diseases |
C00019308
|
| D003072 | Cognition Disorders |
C00019308
|
| D013118 | Spinal Cord Diseases |
C00019308
|
| D008569 | Memory Disorders |
C00003088
|
| D014202 | Tremor |
C00001736
|
| D005621 | Friedreich Ataxia |
C00002145
|
| D005910 | Glioma |
C00002145
|
| D018316 | Gliosarcoma |
C00002145
|
| D006816 | Huntington Disease |
C00002145
|
| D007945 | Leukemia, Lymphoid |
C00002145
|
| D007968 | Leukoencephalopathy, Progressive Multifocal |
C00002145
|
| D009374 | Neoplasms, Experimental |
C00002145
|
| D009503 | Neutropenia |
C00002145
|
| D024801 | Tauopathies |
C00002145
|
| D000647 | Amnesia |
C00002724
|
| D056486 | Drug-Induced Liver Injury |
C00002724
|
| D006937 | Hypercholesterolemia |
C00002724
|
| D006951 | Hyperlipoproteinemias |
C00002724
|
| D015228 | Hypertriglyceridemia |
C00002724
|
| D052456 | Hypoalphalipoproteinemias |
C00002724
|
| D008545 | Melanoma |
C00002724
|
| D009336 | Necrosis |
C00002724
|
| D015431 | Weight Loss |
C00002724
|