KEGG   PATHWAY: rno05163
rno05163                    Pathway                                

Human cytomegalovirus infection - Rattus norvegicus (rat)
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Human Diseases; Infectious disease: viral
Pathway map
rno05163  Human cytomegalovirus infection

Rattus norvegicus (rat) [GN:rno]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:]
60445  Tsc1; hamartin [KO:K07206]
24855  Tsc2; tuberin [KO:K07207]
26954  Rheb; GTP-binding protein Rheb [KO:K07208]
56718  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:]
116636  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
83840  Rps6kb1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:]
361696  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:]
309361  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:]
84351  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:]
309295  Ikbkg; NF-kappa-B essential modulator [KO:K07210]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
24329  Egfr; epidermal growth factor receptor precursor [KO:K04361] [EC:]
81504  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
85384  Sos2; son of sevenless homolog 2 [KO:K03099]
313845  Sos1; son of sevenless homolog 1 [KO:K03099]
293621  Hras; GTPase HRas [KO:K02833]
367858  GTPase HRas [KO:K02833]
24525  Kras; GTPase KRas [KO:K07827]
24605  Nras; GTPase NRas [KO:K07828]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
314436  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
24790  Sp1; transcription factor Sp1 [KO:K04684]
296456  Itgav; integrin alpha-V isoform X1 [KO:K06487]
29302  Itgb3; integrin beta-3 precursor [KO:K06493]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:]
363875  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
366957  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117273  Rhoa; transforming protein RhoA [KO:K04513]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
682147  Cgas; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:]
498840  Sting1; stimulator of interferon genes protein [KO:K12654]
299827  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:]
292892  Irf3; interferon regulatory factor 3 [KO:K05411]
298205  Ifna4; interferon, alpha 4 precursor [KO:K05414]
298213  Ifna2; interferon alpha family, gene 2 precursor [KO:K05414]
298210  Ifna5; interferon alpha-1 precursor [KO:K05414]
690894  Ifna1; interferon alpha-5 [KO:K05414]
100912314  interferon alpha-1-like [KO:K05414]
502961  RGD1559679; interferon alpha-1-like [KO:K05414]
500491  Ifna16l1; interferon alpha-1-like [KO:K05414]
24481  Ifnb1; interferon beta precursor [KO:K05415]
24835  Tnf; tumor necrosis factor [KO:K03156]
25625  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
306886  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:]
246756  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
684173  Traf5; TNF receptor-associated factor 5 [KO:K09849]
311786  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:]
24494  Il1b; interleukin-1 beta [KO:K04519]
25663  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
25493  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
287562  Ccl12; chemokine (C-C motif) ligand 12 precursor [KO:K14624]
24770  Ccl2; C-C motif chemokine 2 precursor [KO:K14624]
81780  Ccl5; C-C motif chemokine 5 precursor [KO:K12499]
24498  Il6; interleukin-6 precursor [KO:K05405]
24400  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
81667  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
60449  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
294962  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
83579  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
80850  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114117  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114118  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
79218  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108349548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
58979  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
245986  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114119  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
64199  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114120  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
685513  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
685451  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
680149  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
690825  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
81662  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
50663  Calm2; calmodulin-2 [KO:K02183]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
24674  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
305897  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
29527  Ptgs2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
50664  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:]
25542  Ccl3; C-C motif chemokine 3 precursor [KO:K05408]
116637  Ccl4; C-C motif chemokine 4 precursor [KO:K12964]
89808  Cx3cl1; fractalkine precursor [KO:K05508]
81663  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
303634  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
60323  Arhgef1; rho guanine nucleotide exchange factor 1 [KO:K12330]
78966  Arhgef11; rho guanine nucleotide exchange factor 11 [KO:K12331]
367072  Arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
293024  Akap13; A-kinase anchor protein 13 [KO:K16529]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:]
84353  Ctnnb1; catenin beta-1 [KO:K02105]
25637  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
81752  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
24929  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
84023  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
84027  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:]
58919  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
24577  Myc; myc proto-oncogene protein [KO:K04377]
24499  Il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055]
84598  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
25125  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
114495  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
406169  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
24772  Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:]
50646  Ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:]
25414  Bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
54245  Crk; adapter molecule crk [KO:K04438]
287942  Crkl; crk-like protein [KO:K04438]
360820  Pxn; paxillin [KO:K05760]
117539  Il10ra; interleukin-10 receptor subunit alpha precursor [KO:K05134]
304091  Il10rb; interleukin-10 receptor subunit beta precursor [KO:K05135]
29385  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
57301  Ccr1; C-C chemokine receptor type 1 [KO:K04176]
301088  Ccr1l1; C-C chemokine receptor 1-like protein 1 [KO:K04176]
117027  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
117029  Ccr5; C-C chemokine receptor type 5 [KO:K04180]
24811  Tap1; antigen peptide transporter 1 precursor [KO:K05653]
24812  Tap2; antigen peptide transporter 2 precursor [KO:K05654]
25217  Tapbp; tapasin precursor [KO:K08058]
29468  Pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:]
64202  Calr; calreticulin precursor [KO:K08057]
689537  Calr4; calreticulin isoform X1 [KO:K08057]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 [KO:K06751]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
414270  RT1-CE14; RT1 class I, locus CE14 isoform 1 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414787  RT1-M10-1; RT1 class I, locus M10, gene 1 precursor [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
102546590  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
24223  B2m; beta-2-microglobulin precursor [KO:K08055]
25163  Cdkn2a; cyclin-dependent kinase inhibitor 2A [KO:K06621]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:]
24842  Tp53; cellular tumor antigen p53 [KO:K04451]
114851  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
94201  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
114483  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
24708  Rb1; retinoblastoma-associated protein [KO:K06618]
399489  E2f1; transcription factor E2F1 [KO:K17454]
684111  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
291105  E2f3; transcription factor E2F3 [KO:K06620]
25385  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
246097  Fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
266610  Fadd; FAS-associated death domain protein [KO:K02373]
64044  Casp8; caspase-8 [KO:K04398] [EC:]
64625  Bid; BH3-interacting domain death agonist [KO:K04726]
24887  Bax; apoptosis regulator BAX [KO:K02159]
116502  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
25309  Cycs; cytochrome c, somatic [KO:K08738]
25310  Cyct; cytochrome c, testis-specific [KO:K08738]
100363502  cytochrome c, somatic [KO:K08738]
58918  Casp9; caspase-9 [KO:K04399] [EC:]
25402  Casp3; caspase-3 [KO:K02187] [EC:]
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
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rno00590  Arachidonic acid metabolism
rno03050  Proteasome
rno04010  MAPK signaling pathway
rno04064  NF-kappa B signaling pathway
rno04110  Cell cycle
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04612  Antigen processing and presentation
rno04623  Cytosolic DNA-sensing pathway
rno04630  JAK-STAT signaling pathway
rno04668  TNF signaling pathway
rno04810  Regulation of actin cytoskeleton
KO pathway

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