Species

KNApSAcK Entry

Organism name Pimenta dioica
Genus Pimenta
Family Myrtaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pimenta dioica
Linked NCBI taxonomy ID 375272
Linked level species

Family

Family in NCBI taxonomy Myrtaceae
ID 3931

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (105)

Species Activity
Pimenta dioica (L.) Merr. Analgesic
Pimenta dioica (L.) Merr. Analgesic
Pimenta dioica (L.) Merr. Anesthetic
Pimenta dioica (L.) Merr. Anesthetic
Pimenta dioica (L.) Merr. Antiaggregant
Pimenta dioica (L.) Merr. Anticonvulsant
Pimenta dioica (L.) Merr. Anticonvulsant
Pimenta dioica (L.) Merr. Antiedemic
Pimenta dioica (L.) Merr. Antiemetic
Pimenta dioica (L.) Merr. Antihemorrhagic
Pimenta dioica (L.) Merr. Antiinflammatory
Pimenta dioica (L.) Merr. Antiophidic
Pimenta dioica (L.) Merr. Antioxidant
Pimenta dioica (L.) Merr. Antioxidant
Pimenta dioica (L.) Merr. Antipyretic
Pimenta dioica (L.) Merr. Antiseptic
Pimenta dioica (L.) Merr. Antiseptic
Pimenta dioica (L.) Merr. Antispasmodic
Pimenta dioica (L.) Merr. Antispasmodic
Pimenta dioica (L.) Merr. Antistroke
Pimenta dioica (L.) Merr. Antiviral
Pimenta dioica (L.) Merr. Antiviral
Pimenta dioica (L.) Merr. Aphrodisiac
Pimenta dioica (L.) Merr. Arthrosis
Pimenta dioica (L.) Merr. Athlete's Foot
Pimenta dioica (L.) Merr. Bacteria
Pimenta dioica (L.) Merr. Bactericide
Pimenta dioica (L.) Merr. Bruise
Pimenta dioica (L.) Merr. Candidicide
Pimenta dioica (L.) Merr. Candidicide
Pimenta dioica (L.) Merr. Cardioprotective
Pimenta dioica (L.) Merr. Cardiotonic
Pimenta dioica (L.) Merr. Carminative
Pimenta dioica (L.) Merr. Carminative
Pimenta dioica (L.) Merr. Circulotonic
Pimenta dioica (L.) Merr. CNS-Depressant
Pimenta dioica (L.) Merr. CNS-Depressant
Pimenta dioica (L.) Merr. Cold
Pimenta dioica (L.) Merr. Colic
Pimenta dioica (L.) Merr. Collagenase-Inhibitor
Pimenta dioica (L.) Merr. Convulsion
Pimenta dioica (L.) Merr. Corn
Pimenta dioica (L.) Merr. COX2-Inhibitor
Pimenta dioica (L.) Merr. Cramp
Pimenta dioica (L.) Merr. Depurative
Pimenta dioica (L.) Merr. Depurative
Pimenta dioica (L.) Merr. Diabetes
Pimenta dioica (L.) Merr. Diarrhea
Pimenta dioica (L.) Merr. Digestive
Pimenta dioica (L.) Merr. Digestive
Pimenta dioica (L.) Merr. Diuretic
Pimenta dioica (L.) Merr. Dysmenorrhea
Pimenta dioica (L.) Merr. Dyspepsia
Pimenta dioica (L.) Merr. Elastase-Inhibitor
Pimenta dioica (L.) Merr. Enterosis
Pimenta dioica (L.) Merr. Enterotonic
Pimenta dioica (L.) Merr. Exthaustion
Pimenta dioica (L.) Merr. Febrifuge
Pimenta dioica (L.) Merr. Fever
Pimenta dioica (L.) Merr. Fungicide
Pimenta dioica (L.) Merr. Fungicide
Pimenta dioica (L.) Merr. Fungus
Pimenta dioica (L.) Merr. Gas
Pimenta dioica (L.) Merr. Gingivosis
Pimenta dioica (L.) Merr. High Blood Pressure
Pimenta dioica (L.) Merr. Hypotensive
Pimenta dioica (L.) Merr. Hypotensive
Pimenta dioica (L.) Merr. Infection
Pimenta dioica (L.) Merr. Irritant
Pimenta dioica (L.) Merr. Irritant
Pimenta dioica (L.) Merr. Larvicide
Pimenta dioica (L.) Merr. Larvicide
Pimenta dioica (L.) Merr. Lipoxygenase-Inhibitor
Pimenta dioica (L.) Merr. Mycosis
Pimenta dioica (L.) Merr. Myorelaxant
Pimenta dioica (L.) Merr. Myosis
Pimenta dioica (L.) Merr. Nervousness
Pimenta dioica (L.) Merr. Neuralgia
Pimenta dioica (L.) Merr. Neurasthenia
Pimenta dioica (L.) Merr. Neurotonic
Pimenta dioica (L.) Merr. Pain
Pimenta dioica (L.) Merr. Parasite
Pimenta dioica (L.) Merr. Parasiticide
Pimenta dioica (L.) Merr. Parasiticide
Pimenta dioica (L.) Merr. Pulmonosis
Pimenta dioica (L.) Merr. Rheumatism
Pimenta dioica (L.) Merr. Rubefacient
Pimenta dioica (L.) Merr. Rubefacient
Pimenta dioica (L.) Merr. Sedative
Pimenta dioica (L.) Merr. Stimulant
Pimenta dioica (L.) Merr. Stimulant
Pimenta dioica (L.) Merr. Stomachache
Pimenta dioica (L.) Merr. Stomachic
Pimenta dioica (L.) Merr. Stomachic
Pimenta dioica (L.) Merr. Stomatosis
Pimenta dioica (L.) Merr. Tonic
Pimenta dioica (L.) Merr. Tonic
Pimenta dioica (L.) Merr. Toothache
Pimenta dioica (L.) Merr. Uterotonic
Pimenta dioica (L.) Merr. Vaginosis
Pimenta dioica (L.) Merr. Vasodilator
Pimenta dioica (L.) Merr. Virus
Pimenta dioica (L.) Merr. vomiting
Pimenta dioica (L.) Merr. Water Retention
Pimenta dioica (L.) Merr. Yeast

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005367 External link 512 Avicularin
/ Avicularine
/ Avicularoside
/ Quercetin 3-alpha-L-arabinofuranoside
/ Quercetin 3-O-alpha-L-arabinofuranoside
CHEMBL471282
CHEMBL1590676
C041388
10 / 2 / 3 No. 2 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00005372 External link 512 Hyperin
/ Hyperoside
/ Quercetin 3-O-galactoside
/ Quercetin 3-O-beta-D-galactoside
/ Quercetin 3-beta-galactopyranoside
/ Quercetin 3-O-beta-D-galactopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
C021304
38 / 43 / 34 4 / 0 No. 2 No. 15
C00005728 External link 512 Myricetin 3-galactoside
/ Myricetin 3-O-galactoside
CHEMBL462244
CHEMBL1221722
No. 2 No. 15
C00001071 External link 512 Myricetin
CHEMBL164
C040015
78 / 70 / 56 39 / 2 No. 3 No. 15
C00000938 External link 512 Ampelopsin
/ Dihydromyricetin
/ (2R,3R)-3,5,7,3',4',5'-Hexahydroxyflavanone
CHEMBL2048508
C106407
6 / 5 / 4 1 / 0 No. 42 No. 14
C00038240 External link 512 3,4-Dimethoxycinnamaldehyde
CHEMBL465888
No. 310 No. 6
C00002728 External link 512 Coniferaldehyde
/ Coniferyl aldehyde
/ 4-Hydroxy-3-methoxycinnamaldehyde
CHEMBL242529
CHEMBL1956165
C075384
1 / 1 / 1 No. 310 No. 6
C00002647 External link 512 Gallic acid
CHEMBL288114
D005707
42 / 53 / 68 52 / 16 No. 817 No. 81
C00002683 External link 512 Vanillin
CHEMBL13883
18 / 8 / 9 No. 1003
C00040485 External link 512 threo-3-Chloro-1-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol
/ (-)-threo-3-Chloro-1-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol
No. 1736
C00000619 External link 512 Eugenol
CHEMBL42710
D005054
103 / 45 / 36 152 / 28 No. 1852 No. 6

Human Protein / Gene in interactions

217 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001071 C00002647 C00002683 C00005367 C00005372 C00005374 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000619 C00001071 C00002647 C00002683 C00005374 0 / 0
P15121 Aldose reductase Enzyme C00001071 C00002647 C00005367 C00005372 C00005374 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001071 C00002647 C00005367 C00005372 C00005374 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001071 C00005367 C00005372 C00005374 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000619 C00001071 C00002647 C00005372 0 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001071 C00002647 C00005372 C00005374 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001071 C00005367 C00005372 C00005374 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001071 C00002728 C00005372 C00005374 1 / 1
Q9Y253 DNA polymerase eta Enzyme C00001071 C00005367 C00005372 C00005374 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001071 C00002647 C00005372 C00005374 0 / 0
O75496 Geminin Unclassified protein C00000619 C00005367 C00005372 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001071 C00005367 C00005374 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000619 C00002647 C00005372 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001071 C00002647 C00005372 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001071 C00002647 C00002683 1 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001071 C00002647 C00005372 4 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001071 C00002647 C00002683 2 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000619 C00001071 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001071 C00005374 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000619 C00001071 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000619 C00001071 0 / 1
P06746 DNA polymerase beta Enzyme C00001071 C00005372 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000619 C00001071 1 / 1
P04062 Glucosylceramidase Enzyme C00001071 C00005372 6 / 4
P35372 Mu-type opioid receptor Opioid receptor C00000619 C00005372 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000619 C00001071 1 / 0
P03372 Estrogen receptor NR3A1 C00000619 C00002647 1 / 1
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000619 C00002683 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000619 C00002647 5 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001071 C00002647 3 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000619 C00001071 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00001071 C00005372 0 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000619 C00002683 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000619 C00002647 0 / 1
P14780 Matrix metalloproteinase-9 M10A C00000619 C00000938 2 / 2
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00000619 C00001071 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002647 C00002683 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00001071 C00005372 3 / 1
P02545 Prelamin-A/C Unclassified protein C00002647 C00005372 11 / 10
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000619 C00002683 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00001071 C00005372 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001071 C00005372 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000619 C00002647 1 / 2
P03956 Interstitial collagenase M10A C00000619 C00000938 0 / 1
P10145 Interleukin-8 Secreted protein C00000619 C00002647 0 / 0
P10275 Androgen receptor NR3C4 C00000619 C00002683 3 / 4
P41143 Delta-type opioid receptor Opioid receptor C00000619 C00005372 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000619 C00002683 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002647 C00005372 4 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000619 C00005372 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001071 C00005372 0 / 1
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00001071 C00005372 1 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001071 C00005372 1 / 4
P41145 Kappa-type opioid receptor Opioid receptor C00000619 C00005372 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001071 C00002647 2 / 3
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001071 C00005372 1 / 0
P07237 Protein disulfide-isomerase Enzyme C00005372 C00005374 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000619 C00001071 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00002647 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000619 0 / 0
P54132 Bloom syndrome protein Enzyme C00001071 1 / 2
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00001071 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000619 0 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00002683 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000619 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00001071 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00001071 0 / 0
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B C00002647 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000619 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000619 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000619 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001071 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000619 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000619 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002647 0 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00001071 1 / 1
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000619 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00001071 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000619 1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001071 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000619 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000619 1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002647 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00001071 0 / 0
P16581 E-selectin Adhesion C00002647 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002647 1 / 2
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002683 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000619 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001071 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000619 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002647 0 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000619 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000619 1 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000619 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000619 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000619 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000619 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000619 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000619 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00000619 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000619 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000619 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00000619 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000619 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000619 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000619 1 / 1
P32245 Melanocortin receptor 4 Melanocortin receptor C00000619 1 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000619 0 / 0
Q14790 Caspase-8 C14 C00001071 2 / 1
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000619 0 / 0
P08311 Cathepsin G S1A C00000619 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000619 1 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00002683 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000619 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000619 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002683 1 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002683 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001071 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00001071 0 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00005367 1 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001071 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001071 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001071 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001071 0 / 0
P39900 Macrophage metalloelastase M10A C00000938 0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00001071 5 / 4
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000619 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000619 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001071 2 / 2
P14679 Tyrosinase Oxidoreductase C00005372 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000619 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000619 2 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002683 1 / 1
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000619 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000619 1 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001071 4 / 4
P21452 Substance-K receptor Neurokinin receptor C00000619 0 / 0
P06276 Cholinesterase Hydrolase C00001071 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000619 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000619 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000619 0 / 0
P06280 Alpha-galactosidase A Enzyme C00005372 1 / 1
P04745 Alpha-amylase 1 Enzyme C00001071 0 / 0
P45452 Collagenase 3 M10A C00000938 1 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00001071 2 / 0
Q96RI1 Bile acid receptor NR1H4 C00002683 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00002647 2 / 3
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000619 1 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002647 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000619 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000619 2 / 1
P17252 Protein kinase C alpha type Alpha C00000619 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002647 0 / 1
P08253 72 kDa type IV collagenase M10A C00000938 1 / 3
P29466 Caspase-1 C14 C00000619 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005372 2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001071 1 / 1
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme C00001071 9 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00001071 5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005367 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000619 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002647 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000619 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00002647 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000619 1 / 0
P12821 Angiotensin-converting enzyme M2 C00002647 4 / 2
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00002647 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000619 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000619 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005372 1 / 1
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000619 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000619 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000619 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000619 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00001071 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001071 0 / 0
P14151 L-selectin Adhesion C00002647 0 / 0
P16109 P-selectin Adhesion C00002647 1 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000619 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000619 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000619 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002647 3 / 0
Q15046 Lysine--tRNA ligase Enzyme C00001071 2 / 1
P78527 DNA-dependent protein kinase catalytic subunit Atypical serine/threonine protein kinase PIKK subfamily C00002683 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000619 0 / 0
P08246 Neutrophil elastase S1A C00000619 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000619 2 / 2
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001071 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001071 2 / 0
Q99700 Ataxin-2 Unclassified protein C00001071 1 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005372 1 / 0
P31941 DNA dC->dU-editing enzyme APOBEC-3A Enzyme C00001071 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000619 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000619 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000619 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000619 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000619 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00002647 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000619 0 / 1
Q04760 Lactoylglutathione lyase Enzyme C00001071 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000619 0 / 0
P08254 Stromelysin-1 M10A C00000938 1 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005372 1 / 1
P22748 Carbonic anhydrase 4 Lyase C00002647 1 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005372 0 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00000619 1 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001071 0 / 0
P40225 Thrombopoietin Unclassified protein C00001071 1 / 1
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002647 7 / 37
O00255 Menin Unclassified protein C00001071 2 / 5
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000619 3 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00001071 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001071 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001071 2 / 1
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00001071 0 / 0

220 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000619 C00001071 C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000619 C00001071 C00005374
581 BAX, BCL2L4 BCL2-associated X protein C00001071 C00002647 C00005372
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00001071 C00002647 C00005372
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000619 C00001071 C00002647
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000619 C00001071 C00002647
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000619 C00001071 C00002647
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000619 C00001071 C00002647
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00000619 C00001071
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000619 C00002647
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001071 C00002647
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00000619 C00002647
847 CAT catalase (EC:1.11.1.6) C00000619 C00001071
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000619 C00002647
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001071 C00002647
23411 SIRT1, SIR2L1 sirtuin 1 C00001071 C00005372
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000619 C00005372
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000619 C00001071
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00001071 C00002647
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001071 C00002647
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000619 C00001071
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00000619 C00001071
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002647
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00001071
54583 EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6 egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) C00001071
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00001071
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00001071
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00001071
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00001071
8505 PARG, PARG99 poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) C00001071
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001071
8000 PSCA, PRO232 prostate stem cell antigen C00001071
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00001071
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00001071
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00001071
891 CCNB1, CCNB cyclin B1 C00001071
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00001071
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00001071
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001071
7161 TP73, P73 tumor protein p73 C00001071
8877 SPHK1, SPHK sphingosine kinase 1 (EC:2.7.1.91) C00000938
23460 ABCA6, EST155051 ATP-binding cassette, sub-family A (ABC1), member 6 C00000619
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000619
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00000619
57016 AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) C00000619
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000619
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000619
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00000619
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00000619
55114 ARHGAP17, MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH1, RICH1B, WBP15 Rho GTPase activating protein 17 C00000619
10123 ARL4C, ARL7, LAK ADP-ribosylation factor-like 4C C00000619
567 B2M beta-2-microglobulin C00000619
9774 BCLAF1, BTF, bK211L9.1 BCL2-associated transcription factor 1 C00000619
654 BMP6, VGR, VGR1 bone morphogenetic protein 6 C00000619
699 BUB1, BUB1A, BUB1L, hBUB1 BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1) C00000619
57102 C12orf4 chromosome 12 open reading frame 4 C00000619
10203 CALCRL, CGRPR, CRLR calcitonin receptor-like C00000619
6357 CCL13, CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1 chemokine (C-C motif) ligand 13 C00000619
6363 CCL19, CKb11, ELC, MIP-3b, MIP3B, SCYA19 chemokine (C-C motif) ligand 19 C00000619
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000619
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00000619
6349 CCL3L1, 464.2, D17S1718, G0S19-2, LD78, LD78BETA, MIP1AP, SCYA3L, SCYA3L1 chemokine (C-C motif) ligand 3-like 1 C00000619
6351 CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 chemokine (C-C motif) ligand 4 C00000619
729230 CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R chemokine (C-C motif) receptor 2 C00000619
1234 CCR5, CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 chemokine (C-C motif) receptor 5 (gene/pseudogene) C00000619
1236 CCR7, BLR2, CD197, CDw197, CMKBR7, EBI1 chemokine (C-C motif) receptor 7 C00000619
948 CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 CD36 molecule (thrombospondin receptor) C00000619
942 CD86, B7-2, B7.2, B70, CD28LG2, LAB72 CD86 molecule C00000619
1385 CREB1, CREB cAMP responsive element binding protein 1 C00000619
1390 CREM, CREM-2, ICER, hCREM-2 cAMP responsive element modulator C00000619
1514 CTSL, CATL, CTSL1, MEP cathepsin L (EC:3.4.22.15) C00000619
2919 CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) C00000619
397 ARHGDIB, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2 Rho GDP dissociation inhibitor (GDI) beta C00001071
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000619
1593 CYP27A1, CP27, CTX, CYP27 cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) C00000619
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000619
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00000619
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00000619
1736 DKC1, CBF5, DKC, DKCX, NAP57, NOLA4, XAP101 dyskeratosis congenita 1, dyskerin C00000619
9787 DLGAP5, DLG7, HURP discs, large (Drosophila) homolog-associated protein 5 C00000619
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00000619
1870 E2F2, E2F-2 E2F transcription factor 2 C00000619
1871 E2F3, E2F-3 E2F transcription factor 3 C00000619
1874 E2F4, E2F-4 E2F transcription factor 4, p107/p130-binding C00000619
1875 E2F5, E2F-5 E2F transcription factor 5, p130-binding C00000619
1876 E2F6, E2F-6 E2F transcription factor 6 C00000619
1959 EGR2, AT591, CMT1D, CMT4E, KROX20 early growth response 2 C00000619
133418 EMB embigin C00000619
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000619
2162 F13A1, F13A coagulation factor XIII, A1 polypeptide (EC:2.3.2.13) C00000619
26268 FBXO9, FBX9, NY-REN-57, VCIA1, dJ341E18.2 F-box protein 9 C00000619
2213 FCGR2B, CD32, CD32B, FCG2, FCGR2, IGFR2 Fc fragment of IgG, low affinity IIb, receptor (CD32) C00000619
2235 FECH, EPP, FCE ferrochelatase (EC:4.99.1.1) C00000619
2355 FOSL2, FRA2 FOS-like antigen 2 C00000619
2512 FTL, NBIA3 ferritin, light polypeptide C00000619
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00000619
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00000619
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00000619
644076 GLYCAM1 glycosylation dependent cell adhesion molecule 1 (pseudogene) C00000619
2878 GPX3, GPx-P, GSHPx-3, GSHPx-P glutathione peroxidase 3 (plasma) (EC:1.11.1.9) C00000619
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00000619
2936 GSR glutathione reductase (EC:1.8.1.7) C00000619
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00000619
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00000619
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000619
2994 GYPB, CD235b, GPB, GPB.NY, GYPHe.NY, GpMiIII, HGpMiIII, HGpMiVI, HGpMiX, MNS, PAS-3, SS glycophorin B (MNS blood group) C00000619
54497 HEATR5B HEAT repeat containing 5B C00000619
3106 HLA-B, AS, HLAB, SPDA1 major histocompatibility complex, class I, B C00000619
220988 HNRNPA3, 2610510D13Rik, D10S102, FBRNP, HNRPA3 heterogeneous nuclear ribonucleoprotein A3 C00000619
3381 IBSP, BNSP, BSP, BSP-II, SP-II integrin-binding sialoprotein C00000619
3422 IDI1, IPP1, IPPI1 isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) C00000619
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000619
7850 IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB interleukin 1 receptor, type II C00000619
3575 IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA interleukin 7 receptor C00000619
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00001071
26034 IPCEF1, PIP3-E, RP3-402L9.2 interaction protein for cytohesin exchange factors 1 C00000619
3655 ITGA6, CD49f, ITGA6B, VLA-6 integrin, alpha 6 C00000619
3688 ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) C00000619
3741 KCNA5, ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1 potassium voltage-gated channel, shaker-related subfamily, member 5 C00000619
3759 KCNJ2, ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3 potassium inwardly-rectifying channel, subfamily J, member 2 C00000619
9493 KIF23, CHO1, KNSL5, MKLP-1, MKLP1 kinesin family member 23 C00000619
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000619
4097 MAFG, hMAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G C00000619
7975 MAFK, NFE2U, P18 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K C00000619
28985 MCTS1, MCT-1, MCT1 malignant T cell amplified sequence 1 C00000619
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00000619
4257 MGST1, GST12, MGST, MGST-I microsomal glutathione S-transferase 1 (EC:2.5.1.18) C00000619
51318 MRPL35, L35mt, MRP-L35 mitochondrial ribosomal protein L35 C00000619
58475 MS4A7, 4SPAN2, CD20L4, CFFM4, MS4A8 membrane-spanning 4-domains, subfamily A, member 7 C00000619
4501 MT1X, MT-1l, MT1 metallothionein 1X C00000619
4084 MXD1, BHLHC58, MAD, MAD1 MAX dimerization protein 1 C00000619
4602 MYB, Cmyb, c-myb, c-myb_CDS, efg v-myb avian myeloblastosis viral oncogene homolog C00000619
10135 NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN nicotinamide phosphoribosyltransferase (EC:2.4.2.12) C00000619
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00000619
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00000619
4927 NUP88 nucleoporin 88kDa C00000619
10606 PAICS, ADE2, ADE2H1, AIRC, PAIS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (EC:6.3.2.6 4.1.1.21) C00000619
5142 PDE4B, DPDE4, PDE4B5, PDEIVB phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) C00000619
5226 PGD, 6PGD phosphogluconate dehydrogenase (EC:1.1.1.44) C00000619
8301 PICALM, CALM, CLTH, LAP phosphatidylinositol binding clathrin assembly protein C00000619
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000619
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00000619
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00000619
10935 PRDX3, AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III peroxiredoxin 3 (EC:1.11.1.15) C00000619
5733 PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R prostaglandin E receptor 3 (subtype EP3) C00000619
22949 PTGR1, LTB4DH, PGR1, ZADH3 prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) C00000619
5996 RGS1, 1R20, BL34, IER1, IR20 regulator of G-protein signaling 1 C00000619
6157 RPL27A, L27A ribosomal protein L27a C00000619
50484 RRM2B, MTDPS8A, MTDPS8B, P53R2 ribonucleotide reductase M2 B (TP53 inducible) (EC:1.17.4.1) C00000619
6303 SAT1, DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1 spermidine/spermine N1-acetyltransferase 1 (EC:2.3.1.57) C00000619
6383 SDC2, CD362, HSPG, HSPG1, SYND2 syndecan 2 C00000619
55752 SEPT11 septin 11 C00000619
6504 SLAMF1, CD150, CDw150, SLAM signaling lymphocytic activation molecule family member 1 C00000619
117247 SLC16A10, MCT10, PRO0813, TAT1 solute carrier family 16 (aromatic amino acid transporter), member 10 C00000619
6515 SLC2A3, GLUT3 solute carrier family 2 (facilitated glucose transporter), member 3 C00000619
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00000619
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00000619
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00000619
140809 SRXN1, C20orf139, Npn3, SRX, SRX1 sulfiredoxin 1 (EC:1.8.98.2) C00000619
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000619
6775 STAT4, SLEB11 signal transducer and activator of transcription 4 C00000619
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000619
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00000619
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00000619
7130 TNFAIP6, TSG-6, TSG6 tumor necrosis factor, alpha-induced protein 6 C00000619
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001071
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000619
25828 TXN2, MT-TRX, MTRX, TRX2 thioredoxin 2 C00000619
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000619
10587 TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2 thioredoxin reductase 2 (EC:1.8.1.9) C00000619
7358 UGDH, GDH, UDP-GlcDH, UDPGDH, UGD UDP-glucose 6-dehydrogenase (EC:1.1.1.22) C00000619
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000619
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000619
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00000619
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000619
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000619
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000619
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000619
7367 UGT2B17, BMND12, UDPGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17) C00000619
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00000619
7709 ZBTB17, MIZ-1, ZNF151, ZNF60, pHZ-67 zinc finger and BTB domain containing 17 C00000619
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002647
25 ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) C00002647
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002647
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00002647
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00002647
545 ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 ataxia telangiectasia and Rad3 related (EC:2.7.11.1) C00002647
613 BCR, ALL, BCR1, CML, D22S11, D22S662, PHL breakpoint cluster region (EC:2.7.11.1) C00002647
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002647
898 CCNE1, CCNE cyclin E1 C00002647
998 CDC42, CDC42Hs, G25K cell division cycle 42 C00002647
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00001071
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00002647
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00002647
2551 GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 GA binding protein transcription factor, alpha subunit 60kDa C00002647
2885 GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 growth factor receptor-bound protein 2 C00002647
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00002647
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00002647
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00002647
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002647
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002647
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002647
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002647
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00002647
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002647
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) C00002647
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00002647
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00002647
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00002647
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00002647
19412 C00002647
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00002647
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00002647
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) C00002647
9252 RPS6KA5, MSK1, MSPK1, RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) C00002647
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002647
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002647
7224 TRPC5, TRP5 transient receptor potential cation channel, subfamily C, member 5 C00002647
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00002647
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00002647

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (157)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600807 Asthma, susceptibility to Q13093
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#114480 Breast cancer P42336
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#607271 Caspase 8 deficiency Q14790
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P18054
P42336
Q14191
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#615108 Cowden syndrome 5; cws5 P42336
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P04626
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#114550 Hepatocellular carcinoma P08581
P42336
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#147050 Ige responsiveness, atopic; iger Q13093
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#603932 Intervertebral disc disease; idd P14780
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
Q14790
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
P42336
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614674 Periodic fever, menstrual cycle-dependent P08908
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#267430 Renal tubular dysgenesis; rtd P12821
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P12821
P16109
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (124)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
P42336 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P08581 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00213 Hypophosphatasia P05186 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00108 Autoimmune lymphoproliferative syndromes (ALPS) Q14790 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

43 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D010146 Pain C00005374
C00000619
D009362 Neoplasm Metastasis C00000619
C00002647
D009203 Myocardial Infarction C00001071
C00002647
D009361 Neoplasm Invasiveness C00000619
C00002647
D011833 Radiation Injuries, Experimental C00000619
D003877 Dermatitis, Contact C00000619
D003875 Drug Eruptions C00000619
D056486 Drug-Induced Liver Injury C00000619
D006331 Heart Diseases C00000619
D006461 Hemolysis C00000619
D006930 Hyperalgesia C00000619
D006967 Hypersensitivity C00000619
D007249 Inflammation C00000619
D008545 Melanoma C00000619
D001943 Breast Neoplasms C00000619
D005909 Glioblastoma C00001071
D009374 Neoplasms, Experimental C00000619
D009389 Neovascularization, Pathologic C00000619
D009410 Nerve Degeneration C00000619
D010149 Pain, Postoperative C00000619
D010300 Parkinson Disease C00000619
D017449 Dermatitis, Allergic Contact C00000619
D012481 Salmonella Infections, Animal C00000619
D012878 Skin Neoplasms C00000619
D013035 Spasm C00000619
D013203 Staphylococcal Infections C00000619
D013274 Stomach Neoplasms C00000619
D013276 Stomach Ulcer C00000619
D014581 Urticaria C00000619
D002583 Uterine Cervical Neoplasms C00000619
D003921 Diabetes Mellitus, Experimental C00002647
D050171 Dyslipidemias C00002647
D005234 Fatty Liver C00002647
D018149 Glucose Intolerance C00002647
D006937 Hypercholesterolemia C00002647
D006943 Hyperglycemia C00002647
D006949 Hyperlipidemias C00002647
D015228 Hypertriglyceridemia C00002647
D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive C00002647
D008546 Melanoma, Experimental C00002647
D009069 Movement Disorders C00002647
D012516 Osteosarcoma C00002647
D010182 Pancreatic Diseases C00002647