Species

KNApSAcK Entry

Organism name Sorghum bicolor
Genus Sorghum
Family Poaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sorghum bicolor
Linked NCBI taxonomy ID 4558
Linked level species

Family

Family in NCBI taxonomy Poaceae
ID 4479

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Natural Activity

List (10)

Species Activity
Sorghum bicolor (L.) Moench. Antiabortive
Sorghum bicolor (L.) Moench. Aperitif
Sorghum bicolor (L.) Moench. Aphrodisiac
Sorghum bicolor (L.) Moench. Cyanogenic
Sorghum bicolor (L.) Moench. Demulcent
Sorghum bicolor (L.) Moench. Depurative
Sorghum bicolor (L.) Moench. Diuretic
Sorghum bicolor (L.) Moench. Emollient
Sorghum bicolor (L.) Moench. Stomachic
Sorghum bicolor (L.) Moench. Vermifuge

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006753 External link 512 Apigeninidin 5-(5''-caffeylarabinoside)
No. 30 No. 15
C00002896 External link 512 Piceid
/ Resveratrol 3-O-beta-glucopyranoside
/ 3,3',4,5'-Tetrahydroxystilbene 3-O-beta-D-glucopyranoside
CHEMBL142652
CHEMBL509386
CHEMBL597338
CHEMBL1990895
7 / 6 / 4 No. 36 No. 13
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00001442 External link 512 Dhurrin
CHEMBL469825
C011220
No. 45 No. 72
C00006610 External link 512 Apigeninidin
CHEMBL1197890
C104027
No. 71 No. 15
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00007280 External link 512 4-Coumaroyl-CoA
/ p-Coumaroyl-CoA
CHEMBL250086
No. 461 No. 6
C00007260 External link 512 Malonyl CoA
D008316
No. 461 No. 6
C00007263 External link 512 Cinnamoyl-CoA
No. 461 No. 6
C00029532 External link 512 4-Hydroxybenzyl cyanide
/ p-Hydroxyphenylacetonitrile
/ 4-Hydroxy-benzeneacetonitrile
C026914
No. 936 No. 6
C00003483 External link 512 Sorgolactone
No. 1816 No. 38
C00002657 External link 512 p-Formylphenol
/ 4-Hydroxybenzaldehyde
/ p-Hydroxybenzaldehyde
CHEMBL14193
C011483
3 / 2 / 2 No. 2076
C00001397 External link 512 L-Tyrosine
CHEMBL925
CHEMBL108615
CHEMBL1076637
17 / 9 / 14 No. 3303
C00001151 External link 512 Sucrose
/ (+)-Sucrose
CHEMBL253582
CHEMBL1976550
D013395
1 / 0 / 0 4 / 10 No. 3949
C00034140 External link 512 p-Hydroxymandelonitrile
C014601
No. 4586

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001397 2 / 0
P06746 DNA polymerase beta Enzyme C00002896 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00001397 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002896 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001397 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001397 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00001397 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00002657 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00001397 1 / 2
P02768 Serum albumin Secreted protein C00001151 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002896 1 / 0
P23280 Carbonic anhydrase 6 Lyase C00001397 0 / 0
P05164 Myeloperoxidase Enzyme C00001397 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00001397 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00001397 1 / 2
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00002657 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00001397 0 / 0
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00002657 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00002896 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00001397 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002896 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002896 4 / 3
P07451 Carbonic anhydrase 3 Lyase C00001397 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00001397 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002896 0 / 0
O00255 Menin Unclassified protein C00001397 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001397 1 / 2
Q05BR4 SLC16A10 protein Unclassified protein C00001397 0 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001151
55630 SLC39A4, AEZ, AWMS2, ZIP4 solute carrier family 39 (zinc transporter), member 4 C00001151
80834 TAS1R2, GPR71, T1R2, TR2 taste receptor, type 1, member 2 C00001151
83756 TAS1R3, T1R3 taste receptor, type 1, member 3 C00001151

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#254600 Myeloperoxidase deficiency; mpod P05164
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (20)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D019969 Amphetamine-Related Disorders C00001151
D018149 Glucose Intolerance C00001151
D006461 Hemolysis C00001151
D006946 Hyperinsulinism C00001151
D006948 Hyperkinesis C00001151
D006973 Hypertension C00001151
D007333 Insulin Resistance C00001151
D009401 Nephrosis C00001151
C541083 Non-alcoholic Fatty Liver Disease C00001151
D019966 Substance-Related Disorders C00001151