PCIDB

Neolitsea acuminatissima

Species

KNApSAcK Entry

Organism name Neolitsea acuminatissima
Genus Neolitsea
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Neolitsea
Linked NCBI taxonomy ID 128654
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (23)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00027304 External link 512 Boldine
/ d-Boldine
/ (+)-Boldine
CHEMBL388342
CHEMBL1321247
CHEMBL1437753
C011686
34 / 32 / 35 No. 20 No. 4
C00001790 External link 512 Actinodaphnine
/ (+)-Actinodaphnine
/ 1,2-Methylenedioxy-9-hydroxy-10-methoxynoraporphine
CHEMBL518088
CHEMBL1588263
C060992
30 / 32 / 24 No. 20 No. 4
C00001807 External link 512 Anonaine
/ (-)-Anonaine
/ (R)-Annonaine
CHEMBL401798
C098138
1 / 0 / 0 No. 20 No. 4
C00001834 External link 512 Cassythicine
/ (+)-Cassythicine
/ N-Methylactinodaphnine
/ (+)-N-Methylactinodaphnine
CHEMBL464528
No. 20 No. 4
C00044392 External link 512 (-)-Boldine
CHEMBL388342
CHEMBL1321247
CHEMBL1437753
34 / 32 / 35 No. 20 No. 4
C00027433 External link 512 Laurolitsine
/ (+)-Norboldine
/ (+)-Laurolitsine
CHEMBL487388
C109133
No. 20 No. 4
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00001878 External link 512 Liriodenine
/ Oxoushinsunine
/ Spermatheridine
CHEMBL37736
C026980
5 / 3 / 1 No. 74
C00027457 External link 512 Oxoglaucine
/ O-Methylatheroline
CHEMBL470881
C111587
25 / 27 / 24 No. 74
C00044955 External link 512 Neolitacumone B
/ (+)-Neolitacumone B
No. 178 No. 38
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4
C00025988 External link 512 Sebiferine
/ (9R)-Sebiferine
/ O-Methylflavinantine
/ (+)-O-Methylflavinanthine
/ (+)-O-Methylflavinantine
CHEMBL224744
CHEMBL490139
C024736
No. 426 No. 4
C00031628 External link 512 beta-Sitosteryl-D-glucoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
5 / 4 / 2 No. 520
C00044826 External link 512 Isovanillin
CHEMBL275563
C093382
7 / 8 / 4 No. 1003
C00044954 External link 512 Neolitacumone A
No. 1017
C00027422 External link 512 Neolitacumonine
No. 1137
C00044956 External link 512 Neolitacumone C
/ (+)-Neolitacumone C
No. 1624
C00030771 External link 512 Methylparaben
/ p-Methoxycarbonylphenol
CHEMBL325372
C015358
102 / 49 / 57 3 / 0 No. 2169
C00000258 External link 512 2,6-Dimethoxy-p-benzoquinone
CHEMBL448515
C030511
22 / 32 / 55 No. 2517
C00029536 External link 512 p-Anisic acid
/ 4-Methoxybenzoic acid
CHEMBL21932
C004520
3 / 2 / 3 No. 2930
C00007205 External link 512 (+)-Lyoniresinol
CHEMBL455365
CHEMBL1760594
CHEMBL1761710
No. 4145

Human Protein / Gene in interactions

167 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00000258 C00001790 C00027304 C00030771 C00044392 C00044826 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000258 C00003672 C00027304 C00027457 C00030771 C00044392 0 / 1
O75496 Geminin Unclassified protein C00000258 C00001790 C00027304 C00027457 C00044392 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000258 C00001790 C00027304 C00027457 C00044392 4 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 C00027304 C00027457 C00030771 C00044392 1 / 1
P39748 Flap endonuclease 1 Enzyme C00000258 C00001790 C00027304 C00027457 C00044392 0 / 0
P06746 DNA polymerase beta Enzyme C00001790 C00003672 C00023774 C00027457 C00031628 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 C00027304 C00027457 C00030771 C00044392 0 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000258 C00001790 C00027304 C00027457 C00044392 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000258 C00001790 C00027304 C00027457 C00044392 1 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 C00027304 C00027457 C00030771 C00044392 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 C00027304 C00030771 C00044392 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001790 C00027304 C00027457 C00044392 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001790 C00027304 C00027457 C00044392 1 / 1
Q99700 Ataxin-2 Unclassified protein C00000258 C00001790 C00027304 C00044392 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001790 C00027304 C00027457 C00044392 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001790 C00027304 C00027457 C00044392 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001790 C00027304 C00027457 C00044392 11 / 10
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000258 C00001790 C00027304 C00044392 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001790 C00027304 C00027457 C00044392 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001790 C00027304 C00027457 C00044392 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001790 C00027304 C00027457 C00044392 2 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00001790 C00027304 C00044392 C00044826 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001790 C00027304 C00044392 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000258 C00001790 C00027457 2 / 0
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001878 C00027304 C00044392 1 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001878 C00027304 C00044392 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001790 C00027304 C00044392 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000258 C00027457 C00044826 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000258 C00027457 C00030771 0 / 0
O00255 Menin Unclassified protein C00000258 C00027304 C00044392 2 / 5
P03372 Estrogen receptor NR3A1 C00003672 C00030771 1 / 1
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00001807 C00001878 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 C00027457 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00027304 C00044392 3 / 3
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000258 C00001790 1 / 0
P00918 Carbonic anhydrase 2 Lyase C00029536 C00030771 1 / 2
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00027304 C00044392 0 / 0
P00734 Prothrombin S1A C00003672 C00031628 4 / 2
P10253 Lysosomal alpha-glucosidase Hydrolase C00027304 C00044392 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00001910 C00030771 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00027304 C00044392 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000258 C00044826 7 / 3
Q01196 Runt-related transcription factor 1 Unclassified protein C00027304 C00044392 1 / 4
Q16637 Survival motor neuron protein Unclassified protein C00000258 C00001790 4 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 C00031628 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 C00031628 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000258 C00030771 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00030771 C00044826 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00029536 C00030771 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000258 C00030771 7 / 37
P29466 Caspase-1 C14 C00027457 C00030771 0 / 0
P42858 Huntingtin Unclassified protein C00001790 C00027457 1 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00027304 C00044392 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 C00031628 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00027304 C00044392 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00030771 C00044826 1 / 1
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000258 C00001790 2 / 1
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00030771 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00030771 1 / 1
P29274 Adenosine receptor A2a Adenosine receptor C00030771 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00030771 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00030771 1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00030771 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00030771 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001790 2 / 2
O43570 Carbonic anhydrase 12 Lyase C00030771 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00030771 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00030771 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00030771 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00030771 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00030771 2 / 0
P11473 Vitamin D3 receptor NR1I1 C00000258 2 / 3
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00030771 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00030771 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00030771 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00030771 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00030771 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00030771 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00030771 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00030771 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00030771 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00030771 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00030771 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00030771 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00030771 1 / 8
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001878 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00030771 0 / 0
P08311 Cathepsin G S1A C00030771 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00030771 1 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001878 0 / 0
P03956 Interstitial collagenase M10A C00030771 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00030771 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00030771 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00030771 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001790 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00030771 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00001790 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00030771 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00030771 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00030771 0 / 0
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00030771 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00030771 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00030771 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00030771 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00030771 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00030771 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00030771 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00030771 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00030771 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00030771 1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00030771 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00030771 2 / 1
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00030771 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00030771 0 / 1
Q01959 Sodium-dependent dopamine transporter Dopamine C00030771 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00030771 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00030771 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00030771 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00030771 1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00030771 0 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P22303 Acetylcholinesterase Hydrolase C00030771 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00030771 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00030771 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00030771 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00030771 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00030771 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00030771 0 / 0
P51580 Thiopurine S-methyltransferase Enzyme C00029536 1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000258 0 / 0
Q92793 CREB-binding protein Enzyme C00027457 1 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00030771 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00030771 2 / 2
O75164 Lysine-specific demethylase 4A Enzyme C00001790 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00030771 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00030771 5 / 1
P17252 Protein kinase C alpha type Alpha C00030771 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00030771 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00030771 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00030771 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00030771 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00030771 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00030771 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00030771 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00030771 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00030771 0 / 0
Q06278 Aldehyde oxidase Enzyme C00044826 0 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00030771 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00030771 0 / 0
Q2TB90 Putative hexokinase HKDC1 Enzyme C00000258 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00030771 0 / 0
P08246 Neutrophil elastase S1A C00030771 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00030771 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00030771 0 / 3
P21728 D(1A) dopamine receptor Dopamine receptor C00030771 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00001790 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00030771 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00030771
3952 LEP, LEPD, OB, OBS leptin C00030771
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00030771
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (117)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#218030 Apparent mineralocorticoid excess; ame P80365
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180849 Rubinstein-taybi syndrome 1; rsts1 Q92793
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#610460 Thiopurine s-methyltransferase deficiency P51580
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (105)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
Q06278 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00504 Rubinstein-Taybi syndrome Q92793 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)