Species

KNApSAcK Entry

Organism name Stellera chamaejasme
Genus Stellera
Family Thymelaeaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stellera chamaejasme
Linked NCBI taxonomy ID 142738
Linked level species

Family

Family in NCBI taxonomy Thymelaeaceae
ID 39987

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (22)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00040739 External link 512 Symposide
/ (-)-Epiafzelechin 7-O-beta-D-glucopyranoside
No. 12 No. 14
C00000640 External link 512 (+)-Eudesmin
CHEMBL519099
CHEMBL512865
CHEMBL523743
CHEMBL464352
CHEMBL1726879
C105875
2 / 0 / 0 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00006422 External link 512 Neochamaejasmin A
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00006420 External link 512 Chamaejasmin
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00006421 External link 512 Neochamaejasmin B
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00000972 External link 512 Isochamaejasmin
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00006423 External link 512 7-Methylchamaejasmin
No. 57 No. 18
C00014706 External link 512 Ruixianglangdusu B
/ (2R,2'R,3S,3'S)-rel-(+)-2,2',3,3'-Tetrahydro-5,5',7-trihydroxy-7'-methoxy-2,2'-bis(4-methoxyphenyl)-[3,3'-bi-4H-1-benzopyran]-4,4'-dione
No. 57 No. 18
C00006427 External link 512 Chamaejasmenin A
CHEMBL1545093
18 / 28 / 19 No. 57 No. 18
C00031675 External link 512 Chamaejasmenin D
/ (+)-Chamaejasmenin D
No. 57 No. 18
C00006429 External link 512 Chamaejasmenin C
/ Ruixianglangdusu A
No. 57 No. 18
C00031893 External link 512 Isochamaejasmenin B
CHEMBL1545093
18 / 28 / 19 No. 57 No. 18
C00006428 External link 512 Chamaejasmenin B
CHEMBL1545093
18 / 28 / 19 No. 57 No. 18
C00006426 External link 512 Sikokianin A
/ (+)-Sikokianin A
CHEMBL1172171
CHEMBL1172216
No. 57 No. 18
C00040926 External link 512 Coniferinoside
No. 128 No. 72
C00007203 External link 512 (+)-Wikstromol
/ (+)-Nortrachelogenin
CHEMBL453799
CHEMBL1483370
3 / 2 / 2 No. 223 No. 21
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00000602 External link 512 (+)-Lariciresinol
CHEMBL518421
2 / 1 / 1 No. 700 No. 21
C00006589 External link 512 Chamaechromone
No. 2947
C00041064 External link 512 Mohsenone
No. 3144

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P05412 Transcription factor AP-1 Transcription Factor C00000972 C00006420 C00006421 C00006422 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00006427 C00006428 C00031893 3 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00006427 C00006428 C00031893 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006427 C00006428 C00031893 1 / 2
O00255 Menin Unclassified protein C00006427 C00006428 C00031893 2 / 5
P06746 DNA polymerase beta Enzyme C00006427 C00006428 C00031893 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00006427 C00006428 C00031893 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00006427 C00006428 C00031893 1 / 1
P37840 Alpha-synuclein Unclassified protein C00006427 C00006428 C00031893 4 / 2
P17861 X-box-binding protein 1 Unclassified protein C00006427 C00006428 C00031893 1 / 0
P54132 Bloom syndrome protein Enzyme C00006427 C00006428 C00031893 1 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00006427 C00006428 C00031893 4 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00006427 C00006428 C00031893 0 / 0
P39748 Flap endonuclease 1 Enzyme C00006427 C00006428 C00031893 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00006427 C00006428 C00031893 7 / 3
P42858 Huntingtin Unclassified protein C00006427 C00006428 C00031893 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006427 C00006428 C00031893 2 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00006427 C00006428 C00031893 0 / 0
O75496 Geminin Unclassified protein C00006427 C00006428 C00031893 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 C00007203 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000640 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000602 0 / 1
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00000640 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00007203 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
Q99700 Ataxin-2 Unclassified protein C00007203 1 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000602 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143100 Huntington disease; hd P42858
#145000 Hyperparathyroidism 1; hrpt1 O00255
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (28)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)