Species

KNApSAcK Entry

Organism name Wikstroemia sikokiana
Genus Wikstroemia
Family Thymelaeaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Wikstroemia
Linked NCBI taxonomy ID 142693
Linked level genus

Family

Family in NCBI taxonomy Thymelaeaceae
ID 39987

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008956 External link 512 Dihydrodaphnodorin B
CHEMBL1532097
19 / 13 / 11 No. 16 No. 19
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00006421 External link 512 Neochamaejasmin B
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00000972 External link 512 Isochamaejasmin
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00006428 External link 512 Chamaejasmenin B
CHEMBL1545093
18 / 28 / 19 No. 57 No. 18
C00006422 External link 512 Neochamaejasmin A
CHEMBL467196
CHEMBL452374
1 / 0 / 0 No. 57 No. 18
C00006424 External link 512 Sikokianin C
CHEMBL1172171
CHEMBL1172216
No. 57 No. 18
C00006425 External link 512 Sikokianin B
CHEMBL1172171
CHEMBL1172216
No. 57 No. 18
C00006427 External link 512 Chamaejasmenin A
CHEMBL1545093
18 / 28 / 19 No. 57 No. 18
C00006426 External link 512 Sikokianin A
/ (+)-Sikokianin A
CHEMBL1172171
CHEMBL1172216
No. 57 No. 18
C00008955 External link 512 Daphnodorin B
C055028
No. 88
C00008922 External link 512 Wikstrol A
No. 88
C00008796 External link 512 Daphnodorin D1
CHEMBL1433872
10 / 6 / 4 No. 88
C00007203 External link 512 (+)-Wikstromol
/ (+)-Nortrachelogenin
CHEMBL453799
CHEMBL1483370
3 / 2 / 2 No. 223 No. 21
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00000604 External link 512 (-)-Secoisolariciresinol
CHEMBL368347
C060283
2 / 1 / 1 1 / 0 No. 282 No. 21
C00000602 External link 512 (+)-Lariciresinol
CHEMBL518421
2 / 1 / 1 No. 700 No. 21
C00011701 External link 512 [1S-(1R*,4S*,5E,7R*)]-4-Methyl-10-methylene-7-(1-methylethyl)-5-cyclodecene-1,4-diol
CHEMBL513802
No. 1547
C00008958 External link 512 Genkwanol B
No. 2864

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75164 Lysine-specific demethylase 4A Enzyme C00006427 C00006428 C00008796 C00008956 0 / 0
P39748 Flap endonuclease 1 Enzyme C00006427 C00006428 C00008796 C00008956 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006427 C00006428 C00008796 2 / 0
P05412 Transcription factor AP-1 Transcription Factor C00000972 C00006421 C00006422 0 / 0
P37840 Alpha-synuclein Unclassified protein C00006427 C00006428 4 / 2
O00255 Menin Unclassified protein C00006427 C00006428 2 / 5
P06746 DNA polymerase beta Enzyme C00006427 C00006428 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00006427 C00006428 1 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000602 C00000604 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00006427 C00006428 4 / 3
Q99700 Ataxin-2 Unclassified protein C00007203 C00008796 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00008796 C00008956 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006427 C00006428 1 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00006427 C00006428 3 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000602 C00000604 0 / 1
P54132 Bloom syndrome protein Enzyme C00006427 C00006428 1 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 C00007203 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00008796 C00008956 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00008796 C00008956 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00006427 C00006428 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00006427 C00006428 7 / 3
P42858 Huntingtin Unclassified protein C00006427 C00006428 1 / 1
P17861 X-box-binding protein 1 Unclassified protein C00006427 C00006428 1 / 0
O75496 Geminin Unclassified protein C00006427 C00006428 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00006427 C00006428 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00006427 C00006428 1 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00008796 0 / 0
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00008956 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00008956 3 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00008796 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
P45452 Collagenase 3 M10A C00008956 1 / 1
P10696 Alkaline phosphatase, placental-like Enzyme C00008956 0 / 1
P08253 72 kDa type IV collagenase M10A C00008956 1 / 3
P11473 Vitamin D3 receptor NR1I1 C00008956 2 / 3
P07237 Protein disulfide-isomerase Enzyme C00008956 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008796 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00008956 2 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
P39900 Macrophage metalloelastase M10A C00008956 0 / 0
P08254 Stromelysin-1 M10A C00008956 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00008956 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00007203 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00008956 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00008956 2 / 1
P03956 Interstitial collagenase M10A C00008956 0 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000604

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (49)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#127750 Dementia, lewy body; dlb P37840
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143100 Huntington disease; hd P42858
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#603932 Intervertebral disc disease; idd P14780
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#174800 Mccune-albright syndrome; mas P63092
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (39)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00213 Hypophosphatasia P05186 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00017 Esophageal cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)