Piper cubeba
Species
KNApSAcK Entry
| Organism name | Piper cubeba |
|---|---|
| Genus | Piper |
| Family | Piperaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Piper cubeba |
|---|---|
| Linked NCBI taxonomy ID | 405322 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Piperaceae |
|---|---|
| ID | 16739 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Natural Activity
List (17)
| Species | Activity |
|---|---|
| Piper cubeba L. f. | Antibacterial |
| Piper cubeba L. f. | Antiseptic |
| Piper cubeba L. f. | Antiviral |
| Piper cubeba L. f. | Aphrodisiac |
| Piper cubeba L. f. | Astringent |
| Piper cubeba L. f. | Carminative |
| Piper cubeba L. f. | Diuretic |
| Piper cubeba L. f. | Expectorant |
| Piper cubeba L. f. | Fungicide |
| Piper cubeba L. f. | Laxative |
| Piper cubeba L. f. | Litholytic |
| Piper cubeba L. f. | Memorigenic |
| Piper cubeba L. f. | Sedative |
| Piper cubeba L. f. | Stimulant |
| Piper cubeba L. f. | Tonic |
| Piper cubeba L. f. | Urinary Antiseptic |
| Piper cubeba L. f. | Vibriocide |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000659
|
Medioresinol
/ (+)-Medioresinol |
CHEMBL376507
CHEMBL513023 |
2 / 1 / 1 | No. 38 | No. 21 |
|
||
|
C00002598
|
Yatein
/ (-)-Yatein / (-)-Deoxypodorhizone / Dihydroanhydropodorhizol |
CHEMBL345590
CHEMBL471067 CHEMBL2021357 |
C452802
|
2 / 1 / 1 | No. 223 | No. 21 |
|
|
|
C00003120
|
alpha-Cubebene
|
No. 333 | No. 38 |
|
||||
|
C00003121
|
beta-Cubebene
|
No. 333 | No. 38 |
|
||||
|
C00020136
|
Bicyclosesquiphellandrene
|
No. 574 |
|
|||||
|
C00002599
|
(-)-Dihydrocubebin
|
CHEMBL486597
CHEMBL1477391 |
C011228
|
4 / 8 / 4 | No. 629 | No. 21 |
|
|
|
C00002608
|
Hinokinin
/ Hinoquinin / (-)-Hinokinin / (-)-Hinoquinin |
CHEMBL180970
CHEMBL182073 CHEMBL242011 |
C475934
|
2 / 1 / 1 | No. 629 | No. 21 |
|
|
|
C00002591
|
(-)-Cubebin
/ beta-Cubebin / (-)-beta-Cubebin / (8R,8'R,9S)-Cubebin |
CHEMBL182001
CHEMBL399831 |
C433065
|
2 / 1 / 1 | 0 / 2 | No. 629 | No. 21 |
|
|
C00042219
|
alpha-Asarone
|
CHEMBL333306
CHEMBL477752 |
2 / 1 / 1 | No. 723 | No. 6 |
|
||
|
C00003043
|
Dipentene
|
CHEMBL15799
CHEMBL449062 |
7 / 21 / 48 | No. 848 | No. 35 |
|
||
|
C00000726
|
Magnosalin
|
CHEMBL345432
CHEMBL156339 |
2 / 1 / 1 | No. 951 | No. 21 |
|
||
|
C00041984
|
Clusin
/ (-)-Clusin |
CHEMBL479701
CHEMBL476708 |
2 / 1 / 1 | No. 1232 | No. 21 |
|
||
|
C00041985
|
(-)-Cubebinin
|
CHEMBL480296
|
2 / 1 / 1 | No. 1232 | No. 21 |
|
||
|
C00041986
|
(-)-Dihydroclusin
|
CHEMBL469916
|
2 / 1 / 1 | No. 1232 | No. 21 |
|
||
|
C00042499
|
Ethoxyclusin
/ (-)-Ethoxyclusin |
No. 1232 | No. 21 |
|
||||
|
C00010825
|
Isocineple
/ 1,4-Cineole |
C058951
|
No. 4112 | No. 35 |
|
Human Protein / Gene in interactions
11 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000659 C00000726 C00002591 C00002598 C00002599 C00002608 C00041984 C00041985 C00041986 C00042219 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000659 C00000726 C00002591 C00002598 C00002599 C00002608 C00041984 C00041985 C00041986 C00042219 | 0 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003043 | 3 / 1 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003043 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003043 | 11 / 10 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003043 | 0 / 3 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00003043 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002599 | 7 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002599 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003043 | 7 / 37 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003043 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (29)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (51)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|