Tupistra chinensis
Species
KNApSAcK Entry
| Organism name | Tupistra chinensis |
|---|---|
| Genus | Tupistra |
| Family | Convallariaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Tupistra |
|---|---|
| Linked NCBI taxonomy ID | 100497 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Asparagaceae |
|---|---|
| ID | 40552 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002631
|
(+)-Lirioresinol B
/ (+)-Syringaresinol |
CHEMBL361362
CHEMBL402653 |
C042192
|
1 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00047115
|
Tupichigenin A
/ (-)-Tupichigenin A |
CHEMBL463609
|
No. 171 | No. 11 |
|
|||
|
C00045129
|
Tupichigenin F
/ (-)-Tupichigenin F |
No. 171 | No. 11 |
|
||||
|
C00045128
|
Tupichigenin E
/ (-)-Tupichigenin E |
No. 171 | No. 11 |
|
||||
|
C00045127
|
Tupichigenin D
/ (-)-Tupichigenin D |
CHEMBL516162
|
No. 171 | No. 11 |
|
|||
|
C00033458
|
Tupichigenin C
/ (-)-Tupichigenin C |
No. 171 | No. 11 |
|
||||
|
C00033457
|
Tupichigenin B
/ (-)-Tupichigenin B |
No. 171 | No. 11 |
|
||||
|
C00033339
|
Ranmogenin A
/ (-)-Ranmogenin A |
CHEMBL516162
|
No. 171 | No. 11 |
|
|||
|
C00045130
|
Tupichinol B
|
No. 179 | No. 15 |
|
||||
|
C00013245
|
Tupichinol C
/ (R)-3,4-Dihydro-2-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol |
CHEMBL508033
CHEMBL463804 CHEMBL463168 |
4 / 3 / 3 | No. 179 | No. 15 |
|
||
|
C00013261
|
Tupichinol A
/ (2R,3R)-3,4-Dihydro-2-(4-hydroxyphenyl)-7-methoxy-8-methyl-2H-1-benzopyran-3-ol |
CHEMBL464202
|
No. 179 | No. 15 |
|
|||
|
C00002683
|
Vanillin
|
CHEMBL13883
|
18 / 8 / 9 | No. 1003 |
|
|||
|
C00002674
|
Syringic acid
/ 4-Hydroxy-3,5-dimethoxybenzoic acid |
CHEMBL1414
|
C001945
|
12 / 3 / 5 | No. 1073 |
|
||
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00044457
|
4-Allyl-pyrocatechol
|
CHEMBL111134
|
C051268
|
8 / 0 | No. 1114 | No. 6 |
|
|
|
C00002657
|
p-Formylphenol
/ 4-Hydroxybenzaldehyde / p-Hydroxybenzaldehyde |
CHEMBL14193
|
C011483
|
3 / 2 / 2 | No. 2076 |
|
||
|
C00030771
|
Methylparaben
/ p-Methoxycarbonylphenol |
CHEMBL325372
|
C015358
|
102 / 49 / 57 | 3 / 0 | No. 2169 |
|
|
|
C00000207
|
Benzoic acid
|
CHEMBL541
|
D019817
|
97 / 39 / 33 | 24 / 1 | No. 2192 |
|
Human Protein / Gene in interactions
146 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P03372 | Estrogen receptor | NR3A1 | C00000207 C00002682 C00003672 C00013245 C00030771 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000207 C00003672 C00030771 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000207 C00003672 C00030771 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000207 C00003672 C00030771 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000207 C00003672 C00030771 | 1 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000207 C00002683 C00030771 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000207 C00013245 C00030771 | 0 / 1 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000207 C00002683 C00030771 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000207 C00003672 C00030771 | 0 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000207 C00002674 C00030771 | 1 / 2 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002683 C00030771 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000207 C00030771 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00023774 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000207 C00030771 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002683 C00003672 | 1 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000207 C00030771 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002674 C00030771 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000207 C00030771 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000207 C00030771 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000207 C00030771 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000207 C00030771 | 2 / 2 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000207 C00030771 | 0 / 1 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000207 C00030771 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000207 C00003672 | 3 / 2 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000207 C00030771 | 0 / 0 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002657 C00002683 | 1 / 1 |
| P08246 | Neutrophil elastase | S1A | C00000207 C00030771 | 2 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000207 C00030771 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000207 C00030771 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000207 C00030771 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000207 C00030771 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000207 C00030771 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000207 C00030771 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002683 C00023774 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000207 C00030771 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000207 C00030771 | 1 / 1 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000207 C00030771 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000207 C00030771 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000207 C00030771 | 2 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002683 C00030771 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002682 C00030771 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000207 C00030771 | 1 / 8 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000207 C00030771 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000207 C00030771 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000207 C00030771 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000207 C00030771 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000207 C00030771 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000207 C00030771 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000207 C00030771 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000207 C00030771 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000207 C00030771 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000207 C00030771 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000207 C00030771 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000207 C00030771 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000207 C00030771 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002674 C00030771 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000207 C00030771 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002674 C00030771 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000207 C00030771 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000207 C00030771 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000207 C00030771 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000207 C00030771 | 0 / 3 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000207 C00030771 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000207 C00030771 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000207 C00030771 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000207 C00030771 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000207 C00030771 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000207 C00030771 | 0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000207 C00030771 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002674 C00002682 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000207 C00030771 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000207 C00030771 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000207 C00030771 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002674 C00030771 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000207 C00030771 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000207 C00030771 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000207 C00030771 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000207 C00030771 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000207 C00030771 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000207 C00030771 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000207 C00030771 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000207 C00030771 | 1 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000207 C00030771 | 1 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000207 C00030771 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000207 C00030771 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000207 C00030771 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000207 C00030771 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002674 C00030771 | 0 / 1 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000207 C00030771 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000207 C00030771 | 2 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00002657 C00002683 | 1 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000207 C00030771 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000207 C00030771 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000207 C00030771 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000207 C00030771 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000207 C00030771 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000207 C00030771 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000207 C00030771 | 2 / 1 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000207 C00030771 | 1 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000207 C00030771 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002683 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002683 | 2 / 2 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002683 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00013245 | 2 / 2 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002683 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| Q9GZT4 | Serine racemase | Enzyme | C00000207 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00002683 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00002657 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002683 | 0 / 0 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | C00013245 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002674 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000207 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00030771 | 7 / 37 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 | 0 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00002683 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00030771 | 5 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P14920 | D-amino-acid oxidase | Enzyme | C00000207 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002683 | 3 / 4 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000207 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002683 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00030771 | 1 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002674 | 0 / 0 |
| Q99489 | D-aspartate oxidase | Enzyme | C00000207 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002674 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002674 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002674 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
| P78527 | DNA-dependent protein kinase catalytic subunit | Atypical serine/threonine protein kinase PIKK subfamily | C00002683 | 0 / 0 |
40 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00000207
C00002682
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00000207
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00030771
|
| 23563 | CHST5, I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 |
C00044457
|
| 4166 | CHST6, MCDC1 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
C00044457
|
| 56548 | CHST7, C6ST-2, GST-5 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 (EC:2.8.2.17) |
C00044457
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00044457
|
| 2953 | GSTT2, GSTT2B | glutathione S-transferase theta 2 (EC:2.5.1.18) |
C00044457
|
| 8520 | HAT1, KAT1 | histone acetyltransferase 1 (EC:2.3.1.48) |
C00044457
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00044457
|
| 7172 | TPMT | thiopurine S-methyltransferase (EC:2.1.1.67) |
C00044457
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00030771
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
|
| 231 | AKR1B1, ADR, ALDR1, ALR2, AR | aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) |
C00000207
|
| 57016 | AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI | aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) |
C00000207
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00000207
|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00030771
|
| 2235 | FECH, EPP, FCE | ferrochelatase (EC:4.99.1.1) |
C00000207
|
| 2512 | FTL, NBIA3 | ferritin, light polypeptide |
C00000207
|
| 2539 | G6PD, G6PD1 | glucose-6-phosphate dehydrogenase (EC:1.1.1.49) |
C00000207
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00000207
|
| 2730 | GCLM, GLCLR | glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) |
C00000207
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00000207
|
| 2938 | GSTA1, GST2, GSTA1-1, GTH1 | glutathione S-transferase alpha 1 (EC:2.5.1.18) |
C00000207
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000207
|
| 4097 | MAFG, hMAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G |
C00000207
|
| 4199 | ME1, HUMNDME, MES | malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) |
C00000207
|
| 4489 | MT1A, MT1, MT1S, MTC | metallothionein 1A |
C00000207
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00000207
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00000207
|
| 5226 | PGD, 6PGD | phosphogluconate dehydrogenase (EC:1.1.1.44) |
C00000207
|
| 22949 | PTGR1, LTB4DH, PGR1, ZADH3 | prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) |
C00000207
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00000207
|
| 140809 | SRXN1, C20orf139, Npn3, SRX, SRX1 | sulfiredoxin 1 (EC:1.8.98.2) |
C00000207
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00000207
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000207
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (77)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (76)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|