KEGG   PATHWAY: hsa05169Help
Entry
hsa05169                    Pathway                                

Name
Epstein-Barr virus infection - Homo sapiens (human)
Description
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxic T cells, causing infectious mononucleosis during adolescence. Primary infection with EBV is followed by latent infection in which the reservoir B cells are immortalized. EBV tumorigenic potential in Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin lymphoma, and post-transplant B cell lymphomas has been well-documented. Distinct forms of EBV latency and patterns of latent gene expression can contribute to the different tumours.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
hsa05169  Epstein-Barr virus infection
hsa05169

Ortholog table
Network
N00223  EBV EBNA1 to host-cell-protein inhibition
N00224  EBV EBNALP binding to host-cell-protein
N00225  EBV EBNA2 binding to host-cell-protein
N00226  EBV EBNA3A/3B to host-cell-protein inhibition
N00262  EBV EBNA3C to host-cell-protein inhibition
N00263  EBV EBNA3C to host-cell-protein activation
N00264  EBV EBNA3C binding to host-cell-protein
N00265  EBV LMP1 to host-cell-protein activation
N00266  EBV LMP2 to host-cell-protein inhibition
Disease
H00007  Hodgkin lymphoma
H00008  Burkitt lymphoma
H00054  Nasopharyngeal cancer
H00367  Infectious mononucleosis
Organism
Homo sapiens (human) [GN:hsa]
Gene
1380  CR2; complement C3d receptor 2 [KO:K04012]
5430  POLR2A; RNA polymerase II subunit A [KO:K03006] [EC:2.7.7.6]
5431  POLR2B; RNA polymerase II subunit B [KO:K03010] [EC:2.7.7.6]
5432  POLR2C; RNA polymerase II subunit C [KO:K03011]
5439  POLR2J; RNA polymerase II subunit J [KO:K03008]
548644  POLR2J3; RNA polymerase II subunit J3 [KO:K03008]
246721  POLR2J2; RNA polymerase II subunit J2 [KO:K03008]
5433  POLR2D; RNA polymerase II subunit D [KO:K03012]
5436  POLR2G; RNA polymerase II subunit G [KO:K03015]
5438  POLR2I; RNA polymerase II subunit I [KO:K03017]
5434  POLR2E; RNA polymerase II subunit E [KO:K03013]
5435  POLR2F; RNA polymerase II subunit F [KO:K03014]
5437  POLR2H; RNA polymerase II subunit H [KO:K03016]
5440  POLR2K; RNA polymerase II subunit K [KO:K03009]
5441  POLR2L; RNA polymerase II subunit L [KO:K03007]
11128  POLR3A; RNA polymerase III subunit A [KO:K03018] [EC:2.7.7.6]
55703  POLR3B; RNA polymerase III subunit B [KO:K03021] [EC:2.7.7.6]
9533  POLR1C; RNA polymerase I and III subunit C [KO:K03027]
51082  POLR1D; RNA polymerase I and III subunit D [KO:K03020]
10623  POLR3C; RNA polymerase III subunit C [KO:K03023]
661  POLR3D; RNA polymerase III subunit D [KO:K03026]
55718  POLR3E; RNA polymerase III subunit E [KO:K14721]
10621  POLR3F; RNA polymerase III subunit F [KO:K03025]
84265  POLR3GL; RNA polymerase III subunit G like [KO:K03024]
10622  POLR3G; RNA polymerase III subunit G [KO:K03024]
171568  POLR3H; RNA polymerase III subunit H [KO:K03022]
51728  POLR3K; RNA polymerase III subunit K [KO:K03019]
7514  XPO1; exportin 1 [KO:K14290]
5901  RAN; RAN, member RAS oncogene family [KO:K07936]
8021  NUP214; nucleoporin 214 [KO:K14317]
3105  HLA-A; major histocompatibility complex, class I, A [KO:K06751]
3106  HLA-B; major histocompatibility complex, class I, B [KO:K06751]
3107  HLA-C; major histocompatibility complex, class I, C [KO:K06751]
3134  HLA-F; major histocompatibility complex, class I, F [KO:K06751]
3135  HLA-G; major histocompatibility complex, class I, G [KO:K06751]
3133  HLA-E; major histocompatibility complex, class I, E [KO:K06751]
952  CD38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
6693  SPN; sialophorin [KO:K06477]
983  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.23 2.7.11.22]
26993  AKAP8L; A-kinase anchoring protein 8 like [KO:K15978]
3312  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
3303  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
3306  HSPA2; heat shock protein family A (Hsp70) member 2 [KO:K03283]
3305  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
3304  HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]
3310  HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
3315  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
3316  HSPB2; heat shock protein family B (small) member 2 [KO:K09543]
7534  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
7529  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
10971  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
7531  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
7533  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
7532  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
2959  GTF2B; general transcription factor IIB [KO:K03124]
27044  SND1; staphylococcal nuclease and tudor domain containing 1 [KO:K15979]
2960  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
2961  GTF2E2; general transcription factor IIE subunit 2 [KO:K03137]
9759  HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
10014  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
22938  SNW1; SNW domain containing 1 [KO:K06063]
9612  NCOR2; nuclear receptor corepressor 2 [KO:K06065]
11317  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like [KO:K06053]
3516  RBPJ; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
6688  SPI1; Spi-1 proto-oncogene [KO:K09438]
3065  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
3066  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
1387  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
5757  PTMA; prothymosin alpha [KO:K13784]
100506248  prothymosin alpha [KO:K13784]
2208  FCER2; Fc fragment of IgE receptor II [KO:K06468]
2268  FGR; FGR proto-oncogene, Src family tyrosine kinase [KO:K08891] [EC:2.7.10.2]
4609  MYC; MYC proto-oncogene, bHLH transcription factor [KO:K04377]
7157  TP53; tumor protein p53 [KO:K04451]
387332  TBPL2; TATA-box binding protein like 2 [KO:K03120]
9519  TBPL1; TATA-box binding protein like 1 [KO:K03120]
6908  TBP; TATA-box binding protein [KO:K03120]
1026  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
4193  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
5701  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
5700  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
5704  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
5706  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
5702  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
5705  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
5708  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
5707  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
5709  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
5718  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
5717  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
9861  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
5713  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
5719  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
5710  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
10213  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
5714  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
11047  ADRM1; adhesion regulating molecule 1 [KO:K06691]
7979  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
7874  USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
1457  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
1459  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
283106  CSNK2A3; casein kinase 2 alpha 3 [KO:K03097] [EC:2.7.11.1]
1460  CSNK2B; casein kinase 2 beta [KO:K03115]
1027  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
890  CCNA2; cyclin A2 [KO:K06627]
8900  CCNA1; cyclin A1 [KO:K06627]
1017  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
5925  RB1; RB transcriptional corepressor 1 [KO:K06618]
6502  SKP2; S-phase kinase associated protein 2 [KO:K03875]
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
5296  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
8503  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
207  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
208  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
10000  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
2932  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
7185  TRAF1; TNF receptor associated factor 1 [KO:K03172]
7186  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
7187  TRAF3; TNF receptor associated factor 3 [KO:K03174]
7188  TRAF5; TNF receptor associated factor 5 [KO:K09849]
9020  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
1147  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
5971  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
4791  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
8717  TRADD; TNFRSF1A associated via death domain [KO:K03171]
8737  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
4793  NFKBIB; NFKB inhibitor beta [KO:K02581]
4792  NFKBIA; NFKB inhibitor alpha [KO:K04734]
4794  NFKBIE; NFKB inhibitor epsilon [KO:K05872]
4790  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
5970  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
3654  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
7189  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [KO:K04404]
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
5606  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
5608  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
6416  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
5609  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
5599  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
1386  ATF2; activating transcription factor 2 [KO:K04450]
3718  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
956  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
377841  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
953  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
958  CD40; CD40 molecule [KO:K03160]
960  CD44; CD44 molecule (Indian blood group) [KO:K06256]
3683  ITGAL; integrin subunit alpha L [KO:K05718]
965  CD58; CD58 molecule [KO:K06492]
3383  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
7431  VIM; vimentin [KO:K07606]
7128  TNFAIP3; TNF alpha induced protein 3 [KO:K11859] [EC:3.4.19.12]
596  BCL2; BCL2, apoptosis regulator [KO:K02161]
102723407  IGH; immunoglobulin heavy variable 4-38-2-like [KO:K06856]
4067  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
6850  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
5335  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
5336  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
930  CD19; CD19 molecule [KO:K06465]
4734  NEDD4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
23586  DDX58; DExD/H-box helicase 58 [KO:K12646] [EC:3.6.3.14]
3458  IFNG; interferon gamma [KO:K04687]
29110  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
3661  IRF3; interferon regulatory factor 3 [KO:K05411]
3586  IL10; interleukin 10 [KO:K05443]
27102  EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
5610  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
440275  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
3587  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
3588  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
3716  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
7297  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
6774  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
3113  HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752]
3115  HLA-DPB1; major histocompatibility complex, class II, DP beta 1 [KO:K06752]
3117  HLA-DQA1; major histocompatibility complex, class II, DQ alpha 1 [KO:K06752]
3118  HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
3119  HLA-DQB1; major histocompatibility complex, class II, DQ beta 1 [KO:K06752]
3122  HLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
3123  HLA-DRB1; major histocompatibility complex, class II, DR beta 1 [KO:K06752]
3125  HLA-DRB3; major histocompatibility complex, class II, DR beta 3 [KO:K06752]
3126  HLA-DRB4; major histocompatibility complex, class II, DR beta 4 [KO:K06752]
3127  HLA-DRB5; major histocompatibility complex, class II, DR beta 5 [KO:K06752]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kieff E, Rickinson AB.
  Title
Epstein-Barr virus and its replication.
  Journal
Fields Virology. New York, Lippincott-Raven
Reference
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
  Authors
Young LS, Murray PG
  Title
Epstein-Barr virus and oncogenesis: from latent genes to tumours.
  Journal
Oncogene 22:5108-21 (2003)
DOI:10.1038/sj.onc.1206556
Reference
  Authors
Haan KM, Kwok WW, Longnecker R, Speck P
  Title
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor.
  Journal
J Virol 74:2451-4 (2000)
DOI:10.1128/JVI.74.5.2451-2454.2000
Reference
  Authors
Knight JS, Sharma N, Robertson ES
  Title
Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase.
  Journal
Proc Natl Acad Sci U S A 102:18562-6 (2005)
DOI:10.1073/pnas.0503886102
Reference
  Authors
Knight JS, Sharma N, Kalman DE, Robertson ES
  Title
A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells.
  Journal
J Virol 78:12857-67 (2004)
DOI:10.1128/JVI.78.23.12857-12867.2004
Reference
  Authors
Cotter MA 2nd, Robertson ES
  Title
Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha.
  Journal
Mol Cell Biol 20:5722-35 (2000)
DOI:10.1128/MCB.20.15.5722-5735.2000
Reference
  Authors
Eliopoulos AG, Caamano JH, Flavell J, Reynolds GM, Murray PG, Poyet JL, Young LS
  Title
Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway.
  Journal
Oncogene 22:7557-69 (2003)
DOI:10.1038/sj.onc.1207120
Reference
  Authors
Ikeda M, Ikeda A, Longan LC, Longnecker R
  Title
The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.
  Journal
Virology 268:178-91 (2000)
DOI:10.1006/viro.1999.0166
Reference
  Authors
Masucci MG
  Title
Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.
  Journal
Oncogene 23:2107-15 (2004)
DOI:10.1038/sj.onc.1207372
Reference
  Authors
Luftig M, Prinarakis E, Yasui T, Tsichritzis T, Cahir-McFarland E, Inoue J, Nakano H, Mak TW, Yeh WC, Li X, Akira S, Suzuki N, Suzuki S, Mosialos G, Kieff E
  Title
Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
  Journal
Proc Natl Acad Sci U S A 100:15595-600 (2003)
DOI:10.1073/pnas.2136756100
Reference
  Authors
Mainou BA, Everly DN Jr, Raab-Traub N
  Title
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K.
  Journal
Oncogene 24:6917-24 (2005)
DOI:10.1038/sj.onc.1208846
Reference
  Authors
Young KA, Herbert AP, Barlow PN, Holers VM, Hannan JP
  Title
Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.
  Journal
J Virol 82:11217-27 (2008)
DOI:10.1128/JVI.01673-08
Reference
  Authors
Portal D, Rosendorff A, Kieff E
  Title
Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.
  Journal
Proc Natl Acad Sci U S A 103:19278-83 (2006)
DOI:10.1073/pnas.0609320103
Reference
  Authors
Portal D, Zhao B, Calderwood MA, Sommermann T, Johannsen E, Kieff E
  Title
EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.
  Journal
Proc Natl Acad Sci U S A 108:7808-13 (2011)
DOI:10.1073/pnas.1104991108
Reference
  Authors
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD
  Title
A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
  Journal
J Virol 74:1939-47 (2000)
DOI:10.1128/JVI.74.4.1939-1947.2000
Reference
  Authors
Brinkmann MM, Schulz TF
  Title
Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae.
  Journal
J Gen Virol 87:1047-74 (2006)
DOI:10.1099/vir.0.81598-0
Reference
  Authors
Anderson LJ, Longnecker R
  Title
EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway.
  Journal
J Gen Virol 89:1563-8 (2008)
DOI:10.1099/vir.0.2008/001461-0
Reference
PMID:1658397
  Authors
Flemington EK, Goldfeld AE, Speck SH
  Title
Efficient transcription of the Epstein-Barr virus immediate-early BZLF1 and BRLF1 genes requires protein synthesis.
  Journal
J Virol 65:7073-7 (1991)
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J Virol 76:12503-12 (2002)
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Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.
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Virology 388:204-11 (2009)
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Miller CL, Burkhardt AL, Lee JH, Stealey B, Longnecker R, Bolen JB, Kieff E
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Immunity 2:155-66 (1995)
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Boyle SM, Ruvolo V, Gupta AK, Swaminathan S
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J Virol 73:6872-81 (1999)
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J Exp Med 187:1395-402 (1998)
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KO pathway
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