KEGG   PATHWAY: dre04010
Entry
dre04010                    Pathway                                
Name
MAPK signaling pathway - Danio rerio (zebrafish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dre04010  MAPK signaling pathway
dre04010

Other DBs
GO: 0000165
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
569528  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
562059  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X24 [KO:K04344]
555941  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
562796  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X2 [KO:K04849]
170581  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
403310  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
403311  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
564274  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X7 [KO:K04852]
567702  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
559964  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
793708  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
563904  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X6 [KO:K04854]
560875  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
566351  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
405791  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
570683  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
561434  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a precursor [KO:K04858]
101882457  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
568759  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b [KO:K04859]
541376  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a precursor [KO:K04859]
100535196  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
100148645  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2 [KO:K04860]
568225  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X2 [KO:K04861]
100150428  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
436925  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
795492  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform 1 [KO:K04863]
565158  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
559015  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
562422  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
678560  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform 1 [KO:K04865]
322013  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
571193  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
393614  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
569855  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
567438  cacng3a; voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
564883  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
794222  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
797554  cacng4a; voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
797409  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
100331116  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
100003220  cacng6b; voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
100034580  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
100034540  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
100003278  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100003329  cacng8b; voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04873]
550428  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
393998  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
445076  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
563147  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
564064  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
497384  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
100333967  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100006675  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100003514  prkcg; protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
503589  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
406604  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
100331581  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
794574  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
557926  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
550554  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
565241  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b [KO:K04348] [EC:3.1.3.16]
447814  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
564337  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
568885  si:ch211-234p18.3; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
553520  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
558859  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
558453  rasgrp4; RAS guanyl-releasing protein 4 [KO:K04350]
557063  rasgrp2; RAS guanyl-releasing protein 2-like [KO:K12361]
797658  RAS guanyl-releasing protein 2-like [KO:K12361]
563441  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
793952  si:dkey-253i9.4; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
557693  rapgef2; rap guanine nucleotide exchange factor 2 isoform X5 [KO:K08018]
564518  nf1b; neurofibromin isoform X1 [KO:K08052]
326708  nf1a; neurofibromin isoform X3 [KO:K08052]
100002155  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
564822  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
100331895  rasa2; ras GTPase-activating protein 2 [KO:K08053]
415242  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
406714  rap1ab; ras-related protein rap1ab [KO:K04353]
321107  rap1b; ras-related protein Rap-1b [KO:K07836]
403045  egf; pro-epidermal growth factor isoform 1 precursor [KO:K04357]
100034402  tgfa; protransforming growth factor alpha precursor [KO:K08774]
100005049  fgf1b; fibroblast growth factor 1b [KO:K18496]
393733  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
404231  fgf2; fibroblast growth factor 2 [KO:K18497]
359830  fgf10a; fibroblast growth factor 10a precursor [KO:K04358]
30549  fgf3; fibroblast growth factor 3 precursor [KO:K04358]
30560  fgf6a; fibroblast growth factor 6a [KO:K04358]
407737  fgf17; fibroblast growth factor 17 precursor [KO:K04358]
30538  fgf8a; fibroblast growth factor 8 precursor [KO:K04358]
570435  fgf4; fibroblast growth factor 4 precursor [KO:K04358]
692065  fgf16; fibroblast growth factor 16 [KO:K04358]
359829  fgf18a; fibroblast growth factor 18a precursor [KO:K04358]
494455  fgf6b; fibroblast growth factor 6b [KO:K04358]
564770  fgf20b; fibroblast growth factor 20b [KO:K04358]
493181  fgf7; fibroblast growth factor 7 precursor [KO:K04358]
494454  fgf5; fibroblast growth factor 5 precursor [KO:K04358]
100005852  fgf22; fibroblast growth factor 22 precursor [KO:K04358]
359831  fgf24; fibroblast growth factor 24 precursor [KO:K04358]
101883614  fgf9; fibroblast growth factor 4B [KO:K04358]
497639  fgf18b; fibroblast growth factor 18b precursor [KO:K04358]
751792  fgf10b; fibroblast growth factor 10b [KO:K04358]
65089  fgf8b; fibroblast growth factor 8b precursor [KO:K04358]
559630  fgf20a; fibroblast growth factor 20a [KO:K04358]
368245  fgf19; fibroblast growth factor 19 isoform 1 [KO:K22603]
724048  fgf21; fibroblast growth factor 21 precursor [KO:K22429]
494456  fgf23; fibroblast growth factor 23 precursor [KO:K22428]
100537842  uncharacterized protein LOC100537842 isoform X1 [KO:K22428]
58133  ngfb; nerve growth factor isoform 2 [KO:K02582]
30270  ngfa; neurotrophin-7 precursor [KO:K02582]
58118  bdnf; brain-derived neurotrophic factor isoform 1 precursor [KO:K04355]
386825  ntf3; neurotrophin-3 [KO:K04356]
30262  ins; insulin preproprotein [KO:K04526]
566735  insb; preproinsulin b precursor [KO:K04526]
100534937  LOW QUALITY PROTEIN: insulin-like [KO:K04526]
114433  igf1; insulin-like growth factor I precursor [KO:K05459]
30710  igf2a; insulin-like growth factor 2a precursor [KO:K13769]
324215  igf2b; insulin-like growth factor 2b precursor [KO:K13769]
378480  pdgfaa; platelet-derived growth factor alpha polypeptide a precursor [KO:K04359]
767790  pdgfab; platelet-derived growth factor alpha polypeptide b precursor [KO:K04359]
796490  pdgfbb; uncharacterized protein pdgfbb isoform X2 [KO:K04359]
103909601  platelet-derived growth factor subunit A [KO:K04359]
798657  pdgfba; platelet-derived growth factor beta polypeptide a precursor [KO:K17386]
560564  pdgfc; platelet-derived growth factor C isoform X2 [KO:K05450]
100535718  pdgfd; platelet-derived growth factor D [KO:K05450]
100004617  csf1a; macrophage colony-stimulating factor 1a precursor [KO:K05453]
553181  kitlgb; kit ligand b precursor [KO:K05461]
553179  kitlga; kit ligand a precursor [KO:K05461]
30682  vegfaa; vascular endothelial growth factor A-A isoform 1 precursor [KO:K05448]
558154  vegfab; vascular endothelial growth factor Ab isoform 1 precursor [KO:K05448]
557468  pgfb; placenta growth factor isoform X1 [KO:K16859]
101883508  pgfa; placenta growth factor-like [KO:K16859]
403049  vegfc; vascular endothelial growth factor C precursor [KO:K05449]
678512  vegfd; vascular endothelial growth factor D precursor [KO:K05449]
493781  hgfa; hepatocyte growth factor a precursor [KO:K05460]
100334116  hepatocyte growth factor-like [KO:K05460]
114407  angpt1; angiopoietin-1 precursor [KO:K05465]
101101687  angpt2a; angiopoietin-2a precursor [KO:K05466]
114408  angpt2b; angiopoietin-2b precursor [KO:K05466]
117506  efna3b; ephrin-A3b precursor [KO:K05462]
393569  efna1a; ephrin-A1a precursor [KO:K05462]
100006460  efna3a; ephrin-A3 [KO:K05462]
30223  efna5b; ephrin-A5b precursor [KO:K05462]
494151  efna1b; ephrin-A1b precursor [KO:K05462]
100332852  ephrin-A2-like [KO:K05462]
100003450  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
30218  efna2a; ephrin-A2 precursor [KO:K05462]
64256  efna5a; ephrin-A5b isoform X1 [KO:K05462]
79379  gdnfa; glial cell line-derived neurotrophic factor precursor [KO:K05452]
101885082  gdnfb; glial cell line-derived neurotrophic factor-like [KO:K05452]
795602  nrtn; neurturin [KO:K25414]
103910147  neurturin-like [KO:K25414]
101883396  artemin-like isoform X1 [KO:K25415]
101882107  artn; artemin isoform X1 [KO:K25415]
101886628  persephin-like [KO:K25416]
378478  egfra; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
571431  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
386966  erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
544664  erbb3b; receptor tyrosine-protein kinase erbB-3b precursor [KO:K05084] [EC:2.7.10.1]
386635  erbb3a; receptor tyrosine-protein kinase erbB-3a precursor [KO:K05084] [EC:2.7.10.1]
100007677  erbb4a; receptor tyrosine-protein kinase erbB-4 precursor [KO:K05085] [EC:2.7.10.1]
101885162  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
569836  erbb4b; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
30705  fgfr1a; fibroblast growth factor receptor 1-A isoform 1 precursor [KO:K04362] [EC:2.7.10.1]
569566  fibroblast growth factor receptor 1-like [KO:K04362] [EC:2.7.10.1]
567905  fgfr1b; fibroblast growth factor receptor 1b precursor [KO:K04362] [EC:2.7.10.1]
352940  fgfr2; fibroblast growth factor receptor 2 isoform 1 precursor [KO:K05093] [EC:2.7.10.1]
58129  fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
100000160  fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
572204  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
564338  ngfrb; nerve growth factor receptor b precursor [KO:K02583]
100535003  ngfra; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
30546  ntrk1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
570240  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b precursor [KO:K04360] [EC:2.7.10.1]
65090  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a precursor [KO:K04360] [EC:2.7.10.1]
245699  insra; insulin receptor a precursor [KO:K04527] [EC:2.7.10.1]
245700  insrb; insulin receptor b precursor [KO:K04527] [EC:2.7.10.1]
245701  igf1ra; insulin-like growth factor 1a receptor precursor [KO:K05087] [EC:2.7.10.1]
245702  igf1rb; insulin-like growth factor 1b receptor precursor [KO:K05087] [EC:2.7.10.1]
386856  pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
559529  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
64274  csf1ra; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
568405  csf1rb; macrophage colony-stimulating factor 1 receptor 1 [KO:K05090] [EC:2.7.10.1]
30256  kita; mast/stem cell growth factor receptor kita precursor [KO:K05091] [EC:2.7.10.1]
497629  kitb; KIT proto-oncogene, receptor tyrosine kinase b precursor [KO:K05091] [EC:2.7.10.1]
566708  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
544667  flt1; vascular endothelial growth factor receptor 1 isoform 1 precursor [KO:K05096] [EC:2.7.10.1]
796537  kdrl; vascular endothelial growth factor receptor kdr-like precursor [KO:K05096] [EC:2.7.10.1]
30121  flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
554230  kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
100150664  met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
30747  tek; angiopoietin-1 receptor precursor [KO:K05121] [EC:2.7.10.1]
30689  epha2a; ephrin type-A receptor 2a precursor [KO:K05103] [EC:2.7.10.1]
568718  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
30512  ret; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
406308  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
493609  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
561670  sos2; son of sevenless homolog 2 [KO:K03099]
556286  sos1; son of sevenless homolog 1 [KO:K03099]
553656  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
550286  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
445289  kras; GTPase KRas isoform 2 [KO:K07827]
393228  zgc:55558; GTPase KRas [KO:K07827]
30380  nras; GTPase NRas [KO:K07828]
449660  rras; ras-related protein R-Ras [KO:K07830]
550513  rras2; ras-related protein R-Ras2 [KO:K07830]
100536317  si:ch73-116o1.2; ras-related protein M-Ras [KO:K07831]
100317924  mras; ras-related protein M-Ras [KO:K07831]
403063  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
403065  braf; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
30716  raf1a; Raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
557109  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
406728  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
563181  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
100002225  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
553597  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
360144  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399480  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
373121  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
334167  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
555974  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
337670  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
338219  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
571285  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
100009657  rps6ka3b; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
777728  rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
406514  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
556410  atf4b; activating transcription factor 4b [KO:K04374]
567895  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
30093  elk4; ETS domain-containing protein Elk-4 isoform 2 [KO:K04376]
393141  mycb; transcriptional regulator Myc-B [KO:K04377]
30686  myca; transcriptional regulator Myc-A [KO:K04377]
30431  srfa; serum response factor a [KO:K04378]
394198  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
564403  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
570238  fosaa; proto-oncogene c-Fos-like isoform X1 [KO:K04379]
100000342  mapta; microtubule-associated protein tau [KO:K04380]
567833  maptb; microtubule-associated protein tau isoform X9 [KO:K04380]
550548  stmn1b; stathmin 1b [KO:K04381]
678630  stmn1a; stathmin 1a [KO:K04381]
492789  zgc:101699; uncharacterized protein LOC492789 [KO:K16342] [EC:3.1.1.4]
30554  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
565386  pla2g4f.2; cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
100148818  si:ch73-55i23.1; uncharacterized protein LOC100148818 [KO:K16342] [EC:3.1.1.4]
798864  pla2g4f.1; cytosolic phospholipase A2 zeta-like isoform X2 [KO:K16342] [EC:3.1.1.4]
559087  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100148581  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
405785  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
405770  il1b; interleukin-1 beta [KO:K04519]
359834  tgfb1a; transforming growth factor, beta 1a precursor [KO:K13375]
563884  tgfb1b; transforming growth factor beta-1 [KO:K13375]
369194  tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
559723  tgfb2l; transforming growth factor beta-2-like [KO:K13376]
369195  tgfb3; transforming growth factor beta-3 proprotein precursor [KO:K13377]
406471  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
799204  zmp:0000000936; interleukin-1 receptor type 1-like [KO:K04386]
799279  interleukin-1 receptor type 1-like [KO:K04386]
100331351  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
560578  tgfbr1a; TGF-beta receptor type-1a precursor [KO:K04674] [EC:2.7.11.30]
792928  tgfbr1b; TGF-beta receptor type-1b precursor [KO:K04674] [EC:2.7.11.30]
30739  tgfbr2b; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
560446  si:dkey-101k6.5; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
735295  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
768248  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
327204  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
792699  rac1l; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
562838  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
415151  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
437027  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
795167  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
336839  cdc42; cell division control protein 42 homolog isoform 2 [KO:K04393]
556226  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
793158  cdc42l; cell division cycle 42, like [KO:K04393]
58130  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
140621  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
566604  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
557526  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
564295  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100005446  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
561006  daxx; death domain-associated protein 6 [KO:K02308]
403145  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
569226  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
393132  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
554561  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
393548  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
402991  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
431763  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
406304  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
497646  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
406507  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
403084  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
494163  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
569243  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
100005183  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
558281  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
561669  si:zfos-2326c3.2; misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
373103  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
266749  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
325034  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
324125  stk3; serine/threonine-protein kinase 3 [KO:K04412]
678610  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
692287  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
563727  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
100334486  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101886393  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
558321  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
560211  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
560639  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
560932  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
561518  si:ch211-120p12.3; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
404626  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
568412  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
559247  map3k20a; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
405768  protein kinase Npk isoform 1 [KO:K04424] [EC:2.7.11.25]
555703  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100005496  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
553788  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
325488  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
555650  taok3b; serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
556172  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
100004576  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
798408  taok3a; serine/threonine-protein kinase TAO3 isoform X2 [KO:K04429] [EC:2.7.11.1]
100151551  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
403052  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a [KO:K04430] [EC:2.7.12.2]
568951  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b [KO:K04430] [EC:2.7.12.2]
560913  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
65239  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100537717  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
100333948  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
561262  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100318355  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform 3 [KO:K04436]
562529  flna; filamin-A isoform X1 [KO:K04437]
445234  crk; adapter molecule crk [KO:K04438]
556443  crkl; crk-like protein [KO:K04438]
394099  arrb2b; arrestin, beta 2b [KO:K04439]
321378  arrb2a; arrestin, beta 2a [KO:K04439]
553266  arrb1; beta-arrestin-1 [KO:K04439]
569698  mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
562720  mapk8a; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
65236  mapk8b; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
100149273  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
65237  mapk14a; mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
266756  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
30681  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
415185  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
557810  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
562552  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
100002318  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
436608  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
327321  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
557648  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
790934  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
565173  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
561959  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
57925  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
568315  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
561772  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
566869  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3-like isoform X2 [KO:K17333]
335916  jun; transcription factor AP-1 [KO:K04448]
564873  jund; transcription factor jun-D [KO:K04449]
100006516  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
30590  tp53; cellular tumor antigen p53 isoform 2 [KO:K04451]
561924  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
30467  max; protein max [KO:K04453]
30575  mef2ca; myocyte enhancer factor 2ca [KO:K04454]
798771  mef2cb; myocyte enhancer factor 2cb [KO:K04454]
368243  hspb1; heat shock protein beta-1 [KO:K04455]
403146  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
560549  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
378972  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100149794  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101910198  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
30704  ppm1aa; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
405817  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
564875  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
30703  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
100526652  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
559524  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
406340  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
394146  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
327246  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
393854  dusp8a; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
406523  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
445057  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114436  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
353314  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100034609  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100000665  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
568344  dusp3b; dual specificity protein phosphatase 3b [KO:K17614] [EC:3.1.3.16 3.1.3.48]
541536  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
30672  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
100003481  ppm1bb; protein phosphatase 1bb [KO:K04461] [EC:3.1.3.16]
30671  hsp70.3; heat shock cognate 70-kd protein, tandem duplicate 3 [KO:K03283]
393586  hsc70; uncharacterized protein LOC393586 [KO:K03283]
573376  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
560210  hsp70l; heat shock cognate 70-kd protein, like [KO:K03283]
798846  hspa1b; Heat shock 70 kDa protein-like [KO:K03283]
100535101  hsp70.2; heat shock cognate 70-kd protein, tandem duplicate 2 [KO:K03283]
100126123  hsp70.1; heat shock cognate 70-kd protein, tandem duplicate 1 [KO:K03283]
562935  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
497407  mecom; LOW QUALITY PROTEIN: MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
100007679  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
541323  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
431720  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
795766  uncharacterized protein LOC795766 isoform X1 [KO:K04466] [EC:2.7.11.25]
100004261  map3k14a; mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
393287  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
563560  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
541530  ikbkg; NF-kappa-B essential modulator [KO:K07210]
563460  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
405892  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
565756  nfkb1; BICD family-like cargo adapter 1 isoform X2 [KO:K02580]
415100  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
415099  rela; transcription factor p65 [KO:K04735]
795414  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
dre04070  Phosphatidylinositol signaling system
dre04110  Cell cycle
dre04115  p53 signaling pathway
dre04210  Apoptosis
dre04310  Wnt signaling pathway
KO pathway
ko04010   

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Genome (1)   
   KEGG GENOME (1)   
Gene (416)   
   KEGG GENES (416)   
All databases (417)   

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