Piper philippinum

• Index
• Plant Species
• Metabolite list (25)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Piper philippinum
Genus	Piper
Family	Piperaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Piper
Linked NCBI taxonomy ID	13215
Linked level	genus

Family

Family in NCBI taxonomy	Piperaceae
ID	16739

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Magnoliophyta
ID	3398

Metabolite list (25)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00004573	3,7,4'-Tri-O-methylkaempferol / Kaempferol 3,7,4'-trimethyl ether / 5-Hydroxy-3,7,4'-trimethoxyflavone / 5-Hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one	CHEMBL77686				No. 35	No. 15
C00003674	Stigmasterol / beta-Stigmasterol	CHEMBL66943 CHEMBL186373 CHEMBL400247 CHEMBL1568947	D013265	5 / 0 / 0	1 / 0	No. 53	No. 11
C00003672	Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol	CHEMBL221542 CHEMBL1398443 CHEMBL1875388		17 / 19 / 12		No. 53	No. 11
C00034357	(22E,24S)-Stigmast-4,22-dien-3-one	CHEMBL307549				No. 53	No. 11
C00027470	Piperolactam A	CHEMBL387864	C457227			No. 125
C00034356	Kusunokinin / (-)-Kusunokinin					No. 223	No. 21
C00034632	Piperphilippinin I					No. 223	No. 21
C00034633	Piperphilippinin II / (-)-Piperphilippinin II					No. 223	No. 21
C00034355	Haplomyrfolin / (-)-Haplomyrfolin					No. 223	No. 21
C00000606	(-)-Matairesinol	CHEMBL425148	C068935	1 / 0 / 0		No. 223	No. 21
C00034637	Piperphilippinin VI					No. 282	No. 21
C00012483	Betula pubescens / Caryophyllene oxide / trans-Caryophyllene oxide / beta-Caryophyllene epoxide / (-)-Epoxydihydrocaryophyllene / 6,7-Epoxy-3(15)-caryophyllene / (-)-beta-Caryophyllene epoxide / 4beta,5alpha-Epoxycaryophyllene / Caryophyllene 4beta,5alpha-epoxide	CHEMBL399036 CHEMBL508894 CHEMBL479134 CHEMBL1513806 CHEMBL1553274		3 / 1 / 3		No. 500
C00002608	Hinokinin / Hinoquinin / (-)-Hinokinin / (-)-Hinoquinin	CHEMBL180970 CHEMBL182073 CHEMBL242011	C475934	2 / 1 / 1		No. 629	No. 21
C00023758	Ergosta-4,6,8(14),22-tetraen-3-one	CHEMBL1801892 CHEMBL2040598	C015860			No. 768
C00002636	Anisaldehyde / p-Anisaldehyde	CHEMBL161598	C024896	11 / 18 / 13	1 / 0	No. 1003
C00034635	Piperphilippinin IV / (-)-Piperphilippinin IV					No. 1029	No. 21
C00034386	3,4-Methylenedioxycinnamic acid					No. 2200
C00034395	(E)-Methyl 4-methoxycinnamate / 4-Methoxy-trans-cinnamic acid					No. 2416
C00002757	4-Methoxycinnamaldehyde / p-Methoxycinnamaldehyde	CHEMBL452173				No. 2748	No. 6
C00029536	p-Anisic acid / 4-Methoxybenzoic acid	CHEMBL21932	C004520	3 / 2 / 3		No. 2930
C00034636	Piperphilippinin V					No. 3222
C00034385	3,4-Methylenedioxycinnamaldehyde					No. 3773
C00002666	Piperonal	CHEMBL271663	C005454	3 / 4 / 4		No. 4093
C00031034	Piperonylic acid / 3,4-Methylenedioxybenzoic acid	CHEMBL573781	C005455	2 / 0 / 0		No. 4093
C00034634	Piperphilippinin III / (-)-Piperphilippinin III					No. 4573

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002608 C00003672 C00012483	0 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00002636 C00002666 C00031034	0 / 0
P03372	Estrogen receptor	NR3A1	C00002636 C00003672	1 / 1
P06746	DNA polymerase beta	Enzyme	C00003672 C00003674	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003672 C00012483	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002608 C00003672	1 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002636 C00003672	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00002636 C00003672	4 / 2
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002666 C00003672	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003672 C00012483	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002636	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00003674	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00029536	1 / 2
P04278	Sex hormone-binding globulin	Secreted protein	C00000606	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00002636	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00029536	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003672	0 / 0
P08183	Multidrug resistance protein 1	drug	C00003672	1 / 0
P00734	Prothrombin	S1A	C00003672	4 / 2
P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002636	1 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002636	5 / 3
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00002636	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00031034	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00002636	3 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002666	3 / 3
P16473	Thyrotropin receptor	Glycohormone receptor	C00003672	3 / 2
P09884	DNA polymerase alpha catalytic subunit	Transferase	C00003674	0 / 0
P51580	Thiopurine S-methyltransferase	Enzyme	C00029536	1 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00003672	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003672	2 / 0
P10275	Androgen receptor	NR3C4	C00002636	3 / 4
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003672	1 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003672	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003674	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00003674	0 / 0

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
8989	TRPA1, ANKTM1, FEPS	transient receptor potential cation channel, subfamily A, member 1	C00002636
10599	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6	solute carrier organic anion transporter family, member 1B1	C00003674

Related Diseases

Diseases related to proteins in ChEMBL interactions