Species

KNApSAcK Entry

Organism name Erythrina poeppigiana
Genus Erythrina
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Erythrina
Linked NCBI taxonomy ID 3841
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (28)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00018965 External link 512 Erysubin F
CHEMBL2159045
1 / 0 / 0 No. 14 No. 15
C00018962 External link 512 Erypoegin H
/ 3,9-Dihydroxy-10-(3-methyl-2-butenyl)-6a,11a-dehydropterocarpan
No. 15 No. 15
C00018966 External link 512 Eryvarin D
CHEMBL1097045
No. 15 No. 15
C00018935 External link 512 Erypoegin E
/ 3,9-Dihydroxy-4-(gamma,gamma-dimethylallyl)pterocarpene
No. 15 No. 15
C00002586 External link 512 Wighteone
/ Erythrinin B
/ 5,7,4'-Trihydroxy-6-prenylisoflavone
CHEMBL393222
2 / 1 / 1 No. 15 No. 15
C00001869 External link 512 Isoboldine
/ (S)-Isoboldine
CHEMBL462880
19 / 22 / 55 No. 20 No. 4
C00009492 External link 512 Alpinumisoflavone
CHEMBL238628
C000154
3 / 1 / 1 1 / 0 No. 24 No. 15
C00018933 External link 512 Vogelin B
/ Erypoegin C
/ 5,7,4'-Trihydroxy-2'-methoxy-5'-prenylisoflavanone
No. 28 No. 14
C00018934 External link 512 Erypoegin D
/ 5,4'-Dihydroxy-7,2'-dimethoxy-5'-prenylisoflavanone
No. 28 No. 14
C00009610 External link 512 Demethylmedicarpin
/ 3,9-Dihydroxypterocarpan
CHEMBL238823
CHEMBL1098413
C042060
No. 66 No. 15
C00002558 External link 512 Phaseollidin
CHEMBL508534
C085158
1 / 0 / 0 No. 188 No. 15
C00009644 External link 512 Sandwicensin
/ 3-Hydroxy-9-methoxy-10-prenylpterocarpan
CHEMBL464750
No. 188 No. 15
C00009640 External link 512 Homoedudiol
/ Sophorapterocarpan A
/ 3,9-Dihydroxy-8-prenylpterocarpan
CHEMBL1088321
1 / 0 / 0 No. 188 No. 15
C00002515 External link 512 Cristacarpin
/ Erythrabyssin I
CHEMBL454849
C085157
2 / 1 / 1 No. 325 No. 15
C00018963 External link 512 Erypoegin I
/ (6aS,11aS)-3,6a-Dihydroxy-9-methoxy-10-(2'-oxo-3'-methylbutyl)pterocarpan
No. 325 No. 15
C00018967 External link 512 Orientanol C
No. 352 No. 15
C00009664 External link 512 Folitenol
CHEMBL551155
1 / 0 / 0 No. 352 No. 15
C00018964 External link 512 Erypoegin J
/ (6aS,11aS)-6a-Hydroxy-9-methoxy-10-(3-methyl-2-butenyl)-2',2'-dimethyl-2H-pyrano[5',6':2,3]pterocarpan
No. 352 No. 15
C00018931 External link 512 Erypoegin A
/ Burttinol C
/ 7,4'-Dihydroxy-2'-methoxy-8-prenylisoflav-3-ene
No. 400
C00001851 External link 512 Erysotrine
CHEMBL442947
No. 446 No. 4
C00018930 External link 512 Erystagallin A
CHEMBL1088462
1 / 0 / 0 No. 460
C00009669 External link 512 Erythrabyssin II
/ 3,9-Dihydroxy-2,10-diprenylpterocarpan
CHEMBL455372
1 / 0 / 0 No. 460
C00018961 External link 512 Erypoegin G
/ 5-Hydroxy-7,2'-dimethoxy-6'',6''-dimethylpyrano[2'',3'':4',5']isoflavanone
No. 589 No. 15
C00009794 External link 512 Angolensin
CHEMBL1373918
5 / 7 / 11 No. 1331 No. 13
C00018960 External link 512 Erypoegin F
/ 3-Carboxyaldehyde-2',4'-dihydroxy-6-methoxy-2-arylbenzofuran
CHEMBL1096946
No. 2156
C00018932 External link 512 Erypoegin B
/ 4'-Hydroxy-2'-methoxy-6'',6''-dimethylpyrano[2'',3'':7,8]isoflav-3-ene
No. 2189
C00036911 External link 512 Cistacarpin
CHEMBL113028
CHEMBL393702
2 / 2 / 2 No. 3909
C00027264 External link 512 8-Oxo-alpha-erythroidine
No. 4287 No. 4

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00002558 C00009492 C00009640 C00009664 C00009669 C00018930 C00018965 C00036911 0 / 0
P03372 Estrogen receptor NR3A1 C00002515 C00002586 C00009492 1 / 1
Q92731 Estrogen receptor beta NR3A2 C00002515 C00002586 C00009492 0 / 1
O00255 Menin Unclassified protein C00001869 C00009794 2 / 5
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001869 C00009794 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001869 C00009794 1 / 2
P10636 Microtubule-associated protein tau Unclassified protein C00001869 C00009794 4 / 3
P55210 Caspase-7 C14 C00001869 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00009794 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001869 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001869 2 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001869 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001869 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001869 1 / 1
P29466 Caspase-1 C14 C00001869 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001869 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00036911 2 / 2
Q9UBT6 DNA polymerase kappa Enzyme C00001869 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001869 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001869 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001869 7 / 37
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001869 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001869 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001869 1 / 4

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00009492

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#609620 Short qt syndrome 1; sqt1 Q12809
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (57)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)