Daphne feddei
Species
KNApSAcK Entry
| Organism name | Daphne feddei |
|---|---|
| Genus | Daphne |
| Family | Thymelaeaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Daphne |
|---|---|
| Linked NCBI taxonomy ID | 66679 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Thymelaeaceae |
|---|---|
| ID | 39987 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (28)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000659
|
Medioresinol
/ (+)-Medioresinol |
CHEMBL376507
CHEMBL513023 |
2 / 1 / 1 | No. 38 | No. 21 |
|
||
|
C00000587
|
(-)-Pinoresinol
|
CHEMBL267963
CHEMBL487611 CHEMBL460862 |
7 / 5 / 6 | No. 38 | No. 21 |
|
||
|
C00038083
|
(+)-Neoolivil
|
CHEMBL464631
CHEMBL577783 |
1 / 0 / 0 | No. 38 | No. 21 |
|
||
|
C00031450
|
(-)-Pinoresinol 4,4'-di-O-beta-D-glucopyranoside
|
CHEMBL450911
CHEMBL573785 CHEMBL1712579 |
2 / 0 / 0 | No. 152 |
|
|||
|
C00000723
|
Liriodendrin
/ Acanthoside D / (+)-Syringaresinol di-O-beta-glucopyranoside |
CHEMBL446836
CHEMBL505393 |
2 / 2 / 2 | No. 152 |
|
|||
|
C00031451
|
(-)-Pinoresinol O-beta-D-glucopyranoside
/ (-)-Pinoresinol 4-O-beta-D-glucopyranoside |
CHEMBL573336
CHEMBL1083218 CHEMBL1302893 |
9 / 6 / 4 | No. 174 | No. 22 |
|
||
|
C00002632
|
Acanthoside B
/ Eleutheroside E1 / (+)-Syringaresinol O-beta-D-glucoside / (+)-Syringaresinol 4'-O-beta-glucopyranoside / (+)-Syringaresinol-4-O-beta-D-glucopyranoside |
CHEMBL573710
CHEMBL1077080 |
C087806
|
No. 174 | No. 22 |
|
||
|
C00002601
|
Eucommin A
|
CHEMBL573786
CHEMBL1076999 |
No. 174 | No. 22 |
|
|||
|
C00000606
|
(-)-Matairesinol
|
CHEMBL425148
|
C068935
|
1 / 0 / 0 | No. 223 | No. 21 |
|
|
|
C00000609
|
(-)-Arctigenin
|
CHEMBL369142
CHEMBL435734 CHEMBL1966556 |
C071942
|
13 / 7 / 6 | No. 223 | No. 21 |
|
|
|
C00007203
|
(+)-Wikstromol
/ (+)-Nortrachelogenin |
CHEMBL453799
CHEMBL1483370 |
3 / 2 / 2 | No. 223 | No. 21 |
|
||
|
C00000604
|
(-)-Secoisolariciresinol
|
CHEMBL368347
|
C060283
|
2 / 1 / 1 | 1 / 0 | No. 282 | No. 21 |
|
|
C00038929
|
Daphneresinol
/ (-)-Daphneresinol |
CHEMBL574120
|
No. 282 | No. 21 |
|
|||
|
C00002728
|
Coniferaldehyde
/ Coniferyl aldehyde / 4-Hydroxy-3-methoxycinnamaldehyde |
CHEMBL242529
CHEMBL1956165 |
C075384
|
1 / 1 / 1 | No. 310 | No. 6 |
|
|
|
C00002775
|
Sinapaldehyde
/ Sinapic aldehyde |
CHEMBL225067
|
C075386
|
No. 310 | No. 6 |
|
||
|
C00007204
|
Isolariciresinol
/ (+)-Isolariciresinol |
CHEMBL399512
CHEMBL1760593 |
C060284
|
2 / 1 / 1 | No. 406 |
|
||
|
C00002986
|
Daphneticin
|
CHEMBL584162
|
No. 485 |
|
||||
|
C00039434
|
Isodaphneticin
|
No. 485 |
|
|||||
|
C00000629
|
(-)-Nortracheloside
|
CHEMBL574493
|
No. 653 | No. 22 |
|
|||
|
C00000646
|
(-)-Arctiin
|
CHEMBL388452
CHEMBL1526371 |
C077992
|
4 / 15 / 11 | 0 / 2 | No. 653 | No. 22 |
|
|
C00032004
|
Matairesinoside
/ (-)-Matairesinoside |
CHEMBL459834
CHEMBL520065 |
No. 653 | No. 22 |
|
|||
|
C00000010
|
Syringin
|
CHEMBL250872
|
C028305
|
1 / 0 / 0 | 0 / 1 | No. 678 | No. 6 |
|
|
C00000602
|
(+)-Lariciresinol
|
CHEMBL518421
|
2 / 1 / 1 | No. 700 | No. 21 |
|
||
|
C00038101
|
(8R,8'R,9R)-4,4',9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan
|
CHEMBL514546
CHEMBL575225 CHEMBL584197 |
No. 700 | No. 21 |
|
|||
|
C00002759
|
Methyl caffeate
|
CHEMBL17001
|
C042405
|
No. 876 |
|
|||
|
C00033844
|
Evofolin B
/ (-)-Evofolin B |
CHEMBL448601
CHEMBL602133 |
No. 2211 |
|
||||
|
C00038930
|
Daphneticin 4''-beta-D-glucopyranoside
|
CHEMBL575616
|
No. 2867 |
|
||||
|
C00038510
|
Armaosigenin
|
No. 8300 |
|
Human Protein / Gene in interactions
36 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000602 C00000604 C00000609 C00000659 C00007204 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000602 C00000604 C00000609 C00000659 C00007204 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00000646 C00000723 C00031450 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000587 C00007203 C00031450 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000609 C00007203 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000609 C00031451 | 0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00000606 C00038083 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00007203 C00031451 | 1 / 1 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000609 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000646 | 11 / 10 |
| P37840 | Alpha-synuclein | Unclassified protein | C00031451 | 4 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002728 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000609 | 0 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000010 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00000723 | 2 / 2 |
| P06746 | DNA polymerase beta | Enzyme | C00031451 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000609 | 2 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000587 | 0 / 3 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000587 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000609 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00031451 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000646 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000587 | 5 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000609 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000609 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000609 | 1 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000587 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000609 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000646 | 4 / 1 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00000609 | 1 / 1 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000587 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00031451 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00031451 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00031451 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00031451 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000587 | 0 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000604
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (36)
| OMIM | preferred title | UniProt |
|---|---|---|
| %606641 | Body mass index; bmi |
P37231
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (29)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|