Araucaria angustifolia
Species
KNApSAcK Entry
| Organism name | Araucaria angustifolia |
|---|---|
| Genus | Araucaria |
| Family | Araucariaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Araucaria angustifolia |
|---|---|
| Linked NCBI taxonomy ID | 56992 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Araucariaceae |
|---|---|
| ID | 25664 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Spermatophyta |
|---|---|
| ID | 58024 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002540
|
Irisolidone
/ 4'-O-Methyltectorigenin / 5,7-Dihydroxy-6,4'-dimethoxyisoflavone |
CHEMBL265945
|
1 / 0 / 0 | No. 3 | No. 15 |
|
||
|
C00006499
|
4',7,7''-Tri-O-methylamentoflavone
/ 7,4',7''-Tri-O-methylamentoflavone |
CHEMBL208578
|
1 / 0 / 0 | No. 34 | No. 18 |
|
||
|
C00009405
|
Cabreuvin
/ 7,3',4'-Trimethoxyisoflavone |
CHEMBL273891
|
7 / 10 / 6 | No. 35 | No. 15 |
|
||
|
C00000640
|
(+)-Eudesmin
|
CHEMBL519099
CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879 |
C105875
|
2 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00007190
|
(+)-Pinoresinol
|
CHEMBL267963
CHEMBL487611 CHEMBL460862 |
C103298
|
7 / 5 / 6 | No. 38 | No. 21 |
|
|
|
C00036233
|
trans-Communic acid
|
CHEMBL498097
CHEMBL1488779 CHEMBL1731589 |
13 / 14 / 8 | No. 143 |
|
|||
|
C00000604
|
(-)-Secoisolariciresinol
|
CHEMBL368347
|
C060283
|
2 / 1 / 1 | 1 / 0 | No. 282 | No. 21 |
|
|
C00007204
|
Isolariciresinol
/ (+)-Isolariciresinol |
CHEMBL399512
CHEMBL1760593 |
C060284
|
2 / 1 / 1 | No. 406 |
|
||
|
C00037574
|
Octadecyl (E)-p-coumarate
|
No. 447 |
|
|||||
|
C00037573
|
Octadecyl (E)-ferulate
|
CHEMBL1669148
|
No. 447 |
|
||||
|
C00037575
|
Octadecyl (Z)-p-coumarate
|
No. 447 |
|
|||||
|
C00002591
|
(-)-Cubebin
/ beta-Cubebin / (-)-beta-Cubebin / (8R,8'R,9S)-Cubebin |
CHEMBL182001
CHEMBL399831 |
C433065
|
2 / 1 / 1 | 0 / 2 | No. 629 | No. 21 |
|
|
C00000603
|
(-)-Lariciresinol
|
CHEMBL518421
|
C060282
|
2 / 1 / 1 | No. 700 | No. 21 |
|
|
|
C00000602
|
(+)-Lariciresinol
|
CHEMBL518421
|
2 / 1 / 1 | No. 700 | No. 21 |
|
||
|
C00000722
|
cis-Hinokiresinol
|
CHEMBL198245
CHEMBL199799 CHEMBL371547 CHEMBL451713 |
C119821
|
No. 922 | No. 24 |
|
||
|
C00000869
|
Abietal
/ 7,13-Abietadien-18-al / Abieta-7,13-diene-18-al |
CHEMBL563793
|
No. 1536 | No. 40 |
|
|||
|
C00000871
|
Abietic acid
/ 7,13-Abietadien-18-oic acid |
CHEMBL71893
CHEMBL1336124 CHEMBL1357151 CHEMBL1514489 CHEMBL1552001 |
C023710
|
18 / 22 / 25 | No. 1536 | No. 40 |
|
|
|
C00022482
|
8,14-Labdadien-13beta,19-diol
|
No. 8408 |
|
Human Protein / Gene in interactions
43 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000602 C00000603 C00000604 C00000871 C00002591 C00007204 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000602 C00000603 C00000604 C00002591 C00007204 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000871 C00009405 C00036233 | 4 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00007190 C00009405 C00036233 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000640 C00036233 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000871 C00036233 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000871 C00007190 | 0 / 3 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00009405 | 1 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000871 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000871 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00036233 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000640 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00009405 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00009405 | 4 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00009405 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00036233 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00036233 | 1 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000871 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00007190 | 5 / 3 |
| P56817 | Beta-secretase 1 | A1A | C00006499 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000871 | 3 / 3 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000871 | 0 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000871 | 11 / 10 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000871 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000871 | 1 / 1 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00007190 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00036233 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00036233 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00036233 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00036233 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00007190 | 0 / 0 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00002540 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00007190 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000871 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000871 | 0 / 0 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00000871 | 0 / 0 |
| Q16654 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial | Pdhk | C00000871 | 0 / 0 |
| Q15119 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial | Pdhk | C00000871 | 0 / 0 |
| Q15120 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial | Pdhk | C00000871 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00036233 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00007190 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00036233 | 2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00009405 | 1 / 1 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00000604
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (44)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #300905 | Charcot-marie-tooth disease, x-linked dominant, 6; cmtx6 |
Q15120
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (35)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|